دورية أكاديمية
Exploring somatosensory innervation of the human lip: A focus on the vermilion.
| العنوان: | Exploring somatosensory innervation of the human lip: A focus on the vermilion. |
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| المؤلفون: | Martín-Cruces J; Departamento de Morfología y Biología Celular - Grupo SINPOs, Universidad de Oviedo, Oviedo, Spain., Martín-Biedma B; Departamento de Cirugía y Especialidades Médico-Quirúrgicas, Universidad de Santiago de Compostela, Santiago de Compostela, Spain., García-Mesa Y; Departamento de Morfología y Biología Celular - Grupo SINPOs, Universidad de Oviedo, Oviedo, Spain., Cuendias P; Departamento de Morfología y Biología Celular - Grupo SINPOs, Universidad de Oviedo, Oviedo, Spain., Gaite JJ; Unidad Dental, Clínica Universitaria de Navarra, Pamplona, Spain., García-Suárez O; Departamento de Morfología y Biología Celular - Grupo SINPOs, Universidad de Oviedo, Oviedo, Spain., Cobo JL; Departamento de Morfología y Biología Celular - Grupo SINPOs, Universidad de Oviedo, Oviedo, Spain; Servico de Cirugía Maxillofacial, Hospital Universitario Central de Asturias, Oviedo, Spain., Vega JA; Departamento de Morfología y Biología Celular - Grupo SINPOs, Universidad de Oviedo, Oviedo, Spain; Facutad de Ciencias de la Salud, Universidad Autónoma de Chile, Santiago de Chile, Chile. Electronic address: javega@uniovi.es. |
| المصدر: | Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft [Ann Anat] 2023 Oct; Vol. 250, pp. 152159. Date of Electronic Publication: 2023 Sep 21. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: G. Fischer Country of Publication: Germany NLM ID: 100963897 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-0402 (Electronic) Linking ISSN: 09409602 NLM ISO Abbreviation: Ann Anat Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Jena [Germany] ; New York : G. Fischer, c1992- |
| مواضيع طبية MeSH: | Lip* , TRPM Cation Channels*, Male ; Female ; Humans ; Middle Aged ; Aged ; Aged, 80 and over ; TRPV Cation Channels ; Mechanoreceptors ; Skin/innervation |
| مستخلص: | Background: The lips are a vital component of the face and are densely innervated to perform various functions. The lip edges are covered with mucocutaneous tissue called vermilion which is particularly receptive to touch and temperature. The aim of this study was to investigate the somatosensory innervation of human lips, focusing on sensory corpuscles and the presence of mechano-gated (ASIC2, PIEZO2, and TRPV4) and thermosensing (TRPV1, TRPM2, and RPM8) ion channels within them. Methods: Twelve intact lips (6 upper and 6 lower) were obtained from non-embalmed frozen cadavers (five females and seven males) with an age range of 60-80 years. The specimens were divided into three zones (medial, lateral, and median). The morphotypes of sensory corpuscles and their immunohistochemical profile was analysed. The occurrence of ion channels involved in mechanosensation and temperature detection was examined using various antibodies. Sensory corpuscle density was quantified in vermilion sections, and statistical analyses were conducted to assess differences between the upper and lower lips, as well as between females and males (p < 0.05). Results: Different morphotypes of sensory corpuscles were identified: Ruffini-like associated with hair follicles, Meissner and glomerular corpuscles in the vermilion, and less classifiable sensory corpuscles within the mucosa. The density of sensory corpuscles in the vermilion was higher in the upper lip than in the lower lip; glomerular corpuscles predominated in the medial and median segments, whereas Meissner corpuscles were more abundant in the lateral segment. No sex-related differences were observed in the density or distribution of the two main corpuscular morphotypes. In contrast, the axons of both the glomeruli and Meissner corpuscles regularly displayed ASIC2 and PIEZO2 immunoreactivity, whereas immunoreactivity for TRPV1, TRPV4, TRPM2, and TRPV8 was absent. Conclusions: These results demonstrate that the sensory corpuscles of the vermilion are a mixture of those typical of glabrous skin mucocutaneous tissues. The presence of PIEZO2 and ASIC2 in their axons suggests that these sensory corpuscles function as mechanosensors. Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2023 The Authors. Published by Elsevier GmbH.. All rights reserved.) |
| فهرسة مساهمة: | Keywords: ASIC2; Glabrous skin; Lip somatosensory innervation; Lips; PIEZO2; Sensory corpuscles |
| المشرفين على المادة: | 0 (TRPV Cation Channels) 0 (TRPM Cation Channels) |
| تواريخ الأحداث: | Date Created: 20230923 Date Completed: 20231027 Latest Revision: 20231027 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.aanat.2023.152159 |
| PMID: | 37741584 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1618-0402 |
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| DOI: | 10.1016/j.aanat.2023.152159 |