دورية أكاديمية
أعرض في EDS

Commensal bacteria signal through TLR5 and AhR to improve barrier integrity and prevent allergic responses to food.

التفاصيل البيبلوغرافية
العنوان: Commensal bacteria signal through TLR5 and AhR to improve barrier integrity and prevent allergic responses to food.
المؤلفون: Kemter AM; Department of Pathology, The University of Chicago, Chicago, IL 60637, USA., Patry RT; Department of Pathology, The University of Chicago, Chicago, IL 60637, USA., Arnold J; Pritzker School of Molecular Engineering, The University of Chicago, Chicago, IL 60637, USA., Hesser LA; Pritzker School of Molecular Engineering, The University of Chicago, Chicago, IL 60637, USA., Campbell E; Committee on Microbiology, The University of Chicago, Chicago, IL 60637, USA., Ionescu E; Pritzker School of Molecular Engineering, The University of Chicago, Chicago, IL 60637, USA., Mimee M; Department of Microbiology, The University of Chicago, Chicago, IL 60637, USA; Pritzker School of Molecular Engineering, The University of Chicago, Chicago, IL 60637, USA; Committee on Microbiology, The University of Chicago, Chicago, IL 60637, USA., Wang S; Department of Pathology, The University of Chicago, Chicago, IL 60637, USA., Nagler CR; Department of Pathology, The University of Chicago, Chicago, IL 60637, USA; Pritzker School of Molecular Engineering, The University of Chicago, Chicago, IL 60637, USA; Committee on Immunology, The University of Chicago, Chicago, IL 60637, USA. Electronic address: cnagler@bsd.uchicago.edu.
المصدر: Cell reports [Cell Rep] 2023 Oct 31; Vol. 42 (10), pp. 113153. Date of Electronic Publication: 2023 Sep 25.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Cambridge, MA] : Cell Press, c 2012-
مواضيع طبية MeSH: Hypersensitivity* , Toll-Like Receptor 5*, Animals ; Mice ; Allergens ; Bacteria ; Ligands ; Mice, Inbred C57BL ; Nuclear Receptor Subfamily 1, Group F, Member 3 ; Receptors, Aryl Hydrocarbon
مستخلص: The increasing prevalence of food allergies has been linked to reduced commensal microbial diversity. In this article, we describe two features of allergy-protective Clostridia that contribute to their beneficial effects. Some Clostridial taxa bear flagella (a ligand for TLR5) and produce indole (a ligand for the aryl hydrocarbon receptor [AhR]). Lysates and flagella from a Clostridia consortium induced interleukin-22 (IL-22) secretion from ileal explants. IL-22 production is abrogated in explants from mice in which TLR5 or MyD88 signaling is deficient either globally or conditionally in CD11c + antigen-presenting cells. AhR signaling in RORγt + cells is necessary for the induction of IL-22. Mice deficient in AhR in RORγt + cells exhibit increased intestinal permeability and are more susceptible to an anaphylactic response to food. Our findings implicate TLR5 and AhR signaling in a molecular mechanism by which commensal Clostridia protect against allergic responses to food.
Competing Interests: Declaration of interests C.R.N. is a co-founder and shareholder of ClostraBio, Inc. A.M.K. is currently an employee of ALK, Hørsholm, Denmark.
(Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.)
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معلومات مُعتمدة: R01 AI106302 United States AI NIAID NIH HHS; R01 AI146099 United States AI NIAID NIH HHS
فهرسة مساهمة: Keywords: AhR; CP: Immunology; IL-22; Microbiology; TLR5; barrier immunity; food allergy; microbiome; oral tolerance
المشرفين على المادة: 0 (Allergens)
0 (Ligands)
0 (Nuclear Receptor Subfamily 1, Group F, Member 3)
0 (Receptors, Aryl Hydrocarbon)
0 (Toll-Like Receptor 5)
0 (Tlr5 protein, mouse)
0 (Ahr protein, mouse)
تواريخ الأحداث: Date Created: 20230924 Date Completed: 20231107 Latest Revision: 20231207
رمز التحديث: 20240514
مُعرف محوري في PubMed: PMC10697505
DOI: 10.1016/j.celrep.2023.113153
PMID: 37742185
قاعدة البيانات: MEDLINE
الوصف
تدمد:2211-1247
DOI:10.1016/j.celrep.2023.113153