دورية أكاديمية
أعرض في EDS

Our biology working against us in obesity: A narrative review on implications for management of osteoarthritis.

التفاصيل البيبلوغرافية
العنوان: Our biology working against us in obesity: A narrative review on implications for management of osteoarthritis.
المؤلفون: Cicuttini FM; School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, 3004, Australia., Proietto J; Department of Medicine, The University of Melbourne, Melbourne, VIC, 3010, Australia., Lim YZ; School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, 3004, Australia.
المصدر: Osteoarthritis and cartilage open [Osteoarthr Cartil Open] 2023 Sep 09; Vol. 5 (4), pp. 100407. Date of Electronic Publication: 2023 Sep 09 (Print Publication: 2023).
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101767068 Publication Model: eCollection Cited Medium: Internet ISSN: 2665-9131 (Electronic) Linking ISSN: 26659131 NLM ISO Abbreviation: Osteoarthr Cartil Open Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [London] : Elsevier Ltd., [2019]-
مستخلص: Obesity is the major modifiable risk factor for osteoarthritis (OA). A major focus of management in OA is weight loss. Although we live in an obesogenic environment, obesity has a predominantly genetic and epigenetic basis. This explains a person's weight set point which is defended by biological mechanisms making weight loss difficult to achieve and maintain long term, regardless of the methods used. Significant weight regain occurs after weight loss, with weight tending to return to pre-treatment levels after cessation of interventions including the glucagon-like peptide-1 (GLP-1) agonists. An area that has received little attention is the slow, insidious weight creep of 0.5-1 kg/year over adulthood that sees individuals relentlessly increase weight. There is evidence that low intensity, personalised lifestyle interventions can prevent this weight creep, providing patients with achievable goals. In this narrative review, we examine the evidence for weight loss in OA, the biological mechanisms that make weight loss difficult to achieve and maintain and the potential negative impacts on patients. We review the evidence for preventing weight gain, the improvement in patient outcomes and the potential for significant healthcare savings through reduced knee replacements. We propose a combined approach of weight loss when indicated, together with targeting weight creep across adult years and the potential role of metformin. Implementing these combined approaches is likely to be more effective in improving patient related outcomes, reducing joint damage and healthcare costs, than our current focus on achieving weight loss in OA.
Competing Interests: JP receives payments from Novo Nordisk and I Nova for educational program and medical advisory board. All other authors declare no conflicts of interest. The funders of the study had no role in the study design and conduct of the study; collection, management, analysis and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
(© 2023 The Authors.)
References: Nat Genet. 2016 May;48(5):497-9. (PMID: 26974008)
Am J Clin Nutr. 2021 Feb 2;113(2):314-323. (PMID: 33471039)
Ann Transl Med. 2020 Oct;8(19):1213. (PMID: 33178745)
N Engl J Med. 2022 Jul 21;387(3):205-216. (PMID: 35658024)
Osteoarthr Cartil Open. 2022 Aug 05;4(4):100298. (PMID: 36474793)
N Engl J Med. 2002 May 23;346(21):1623-30. (PMID: 12023994)
Science. 1999 Jan 8;283(5399):212-4. (PMID: 9880251)
Semin Arthritis Rheum. 2019 Dec;49(3):337-350. (PMID: 31126594)
N Engl J Med. 1990 May 24;322(21):1483-7. (PMID: 2336075)
J Manag Care Spec Pharm. 2021 Mar;27(3):354-366. (PMID: 33470881)
Curr Pharm Des. 2017;23(17):2532-2550. (PMID: 27908266)
Osteoarthritis Cartilage. 2018 Nov;26(11):1447-1452. (PMID: 30041054)
N Engl J Med. 1976 Aug 12;295(7):349-53. (PMID: 934222)
Am J Clin Nutr. 2001 Nov;74(5):579-84. (PMID: 11684524)
Arch Fam Med. 1994 Oct;3(10):888-92. (PMID: 8000560)
N Engl J Med. 1986 Jan 23;314(4):193-8. (PMID: 3941707)
Am J Prev Med. 2010 Feb;38(2):163-70. (PMID: 20117572)
Osteoarthritis Cartilage. 2019 Nov;27(11):1578-1589. (PMID: 31278997)
NCHS Data Brief. 2020 Feb;(360):1-8. (PMID: 32487284)
Obes Rev. 2021 Oct;22(10):e13280. (PMID: 34028958)
Obes Res. 1998 Jul;6(4):278-84. (PMID: 9688104)
Obes Rev. 2021 Aug;22(8):e13230. (PMID: 33855769)
Osteoarthritis Cartilage. 2020 Jan;28(1):10-21. (PMID: 31778811)
Eur J Endocrinol. 1996 Dec;135(6):659-62. (PMID: 9025708)
Curr Hypertens Rep. 2019 Feb 12;21(2):16. (PMID: 30747357)
Arthritis Care Res (Hoboken). 2020 Feb;72(2):149-162. (PMID: 31908149)
J Clin Endocrinol Metab. 1999 Aug;84(8):2751-4. (PMID: 10443673)
Ann N Y Acad Sci. 2017 Dec;1410(1):68-84. (PMID: 29265416)
Reumatismo. 2019 Sep 23;71(S1):5-21. (PMID: 31948191)
Surg Endosc. 2021 Aug;35(8):4069-4084. (PMID: 33650001)
N Engl J Med. 2011 Oct 27;365(17):1597-604. (PMID: 22029981)
Osteoarthritis Cartilage. 2004 May;12(5):389-99. (PMID: 15094138)
Eur J Clin Nutr. 2013 Jul;67(7):759-64. (PMID: 23632752)
Am J Prev Med. 2007 Jul;33(1):34-40. (PMID: 17572309)
Rheumatol Int. 2018 Aug;38(8):1315-1331. (PMID: 29777340)
Am J Clin Nutr. 2008 May;87(5):1238-46. (PMID: 18469245)
Osteoarthritis Cartilage. 2023 Mar;31(3):397-405. (PMID: 36521732)
N Engl J Med. 1990 May 24;322(21):1477-82. (PMID: 2336074)
Osteoarthritis Cartilage. 2015 Jul;23(7):1090-8. (PMID: 25887362)
Curr Obes Rep. 2019 Jun;8(2):156-164. (PMID: 30874963)
Eur J Clin Invest. 2021 Jul;51(7):e13536. (PMID: 33709434)
Ann Rheum Dis. 2013 Jul;72(7):1125-35. (PMID: 23595142)
Obesity (Silver Spring). 2023 Feb;31(2):399-411. (PMID: 36536482)
Metab Syndr Relat Disord. 2011 Apr;9(2):85-9. (PMID: 21117971)
Nat Neurosci. 2001 Jun;4(6):605-11. (PMID: 11369941)
Ann Intern Med. 2022 Feb;175(2):198-209. (PMID: 34843383)
J Physiol. 2009 Oct 15;587(Pt 20):4963-76. (PMID: 19723777)
Obesity (Silver Spring). 2022 Apr;30(4):911-919. (PMID: 35253406)
Ann Rheum Dis. 2004 Aug;63(8):901-7. (PMID: 15020311)
JAMA. 2017 Jul 18;318(3):255-269. (PMID: 28719691)
Am J Clin Nutr. 2008 Oct;88(4):906-12. (PMID: 18842775)
Obes Rev. 2017 Jan;18(1):32-50. (PMID: 27653242)
BMJ Open. 2014 Jan 16;4(1):e003667. (PMID: 24440794)
Nat Rev Rheumatol. 2021 Oct;17(10):621-632. (PMID: 34465902)
Intern Med J. 2016 Apr;46(4):435-42. (PMID: 26762652)
Obes Res. 2004 Dec;12 Suppl:151S-62S. (PMID: 15687411)
Curr Obes Rep. 2017 Dec;6(4):362-370. (PMID: 29101738)
Int J Obes (Lond). 2021 Sep;45(9):1976-1985. (PMID: 34059785)
Rev Bras Epidemiol. 2020;23:e200045. (PMID: 32491047)
N Engl J Med. 2022 Apr 21;386(16):1495-1504. (PMID: 35443107)
JAMA. 2013 Sep 25;310(12):1263-73. (PMID: 24065013)
Proc Natl Acad Sci U S A. 2018 Jan 9;115(2):427-432. (PMID: 29279372)
FASEB J. 1990 Dec;4(15):3310-8. (PMID: 2253845)
BMJ. 2021 Aug 17;374:n1840. (PMID: 34404631)
J Clin Rheumatol. 2016 Oct;22(7):345-54. (PMID: 27660931)
JAMA. 2022 Jan 11;327(2):138-150. (PMID: 35015037)
Ann Surg. 2006 Nov;244(5):734-40. (PMID: 17060766)
Arthritis Res Ther. 2018 Apr 17;20(1):74. (PMID: 29665829)
World Health Organ Tech Rep Ser. 2000;894:i-xii, 1-253. (PMID: 11234459)
Lancet. 2022 Jan 15;399(10321):259-269. (PMID: 34895470)
J Am Diet Assoc. 2010 Apr;110(4):571-84. (PMID: 20338283)
Med Clin North Am. 2018 Jan;102(1):183-197. (PMID: 29156185)
N Engl J Med. 1995 Mar 9;332(10):621-8. (PMID: 7632212)
Diabetes Care. 2018 May;41(5):1106-1115. (PMID: 29678867)
J Obes. 2022 May 6;2022:7652408. (PMID: 35574515)
Nat Rev Dis Primers. 2016 Oct 13;2:16072. (PMID: 27734845)
Obes Rev. 2018 Nov;19(11):1597-1607. (PMID: 30051952)
JAMA. 2021 Feb 9;325(6):568-578. (PMID: 33560326)
فهرسة مساهمة: Keywords: Obesity; Osteoarthritis; Review
تواريخ الأحداث: Date Created: 20230925 Latest Revision: 20230926
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10514453
DOI: 10.1016/j.ocarto.2023.100407
PMID: 37744021
قاعدة البيانات: MEDLINE
الوصف
تدمد:2665-9131
DOI:10.1016/j.ocarto.2023.100407