دورية أكاديمية
Exploring the interplay between metabolomics and genetics in Parkinson's disease: Insights from ongoing research and future avenues.
| العنوان: | Exploring the interplay between metabolomics and genetics in Parkinson's disease: Insights from ongoing research and future avenues. |
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| المؤلفون: | Santos-Rebouças CB; Human Genetics Service, Department of Genetics, Institute of Biology Roberto Alcantara Gomes, Rio de Janeiro State University, Rio de Janeiro, Brazil. Electronic address: cbs@uerj.br., Cordovil Cotrin J; Human Genetics Service, Department of Genetics, Institute of Biology Roberto Alcantara Gomes, Rio de Janeiro State University, Rio de Janeiro, Brazil., Dos Santos Junior GC; LabMet, Department of Genetics, Institute of Biology Roberto Alcantara Gomes, Rio de Janeiro State University, Rio de Janeiro, Brazil. |
| المصدر: | Mechanisms of ageing and development [Mech Ageing Dev] 2023 Dec; Vol. 216, pp. 111875. Date of Electronic Publication: 2023 Sep 23. |
| نوع المنشور: | Review; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Ireland Country of Publication: Ireland NLM ID: 0347227 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-6216 (Electronic) Linking ISSN: 00476374 NLM ISO Abbreviation: Mech Ageing Dev Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Limerick : Elsevier Science Ireland Original Publication: Lausanne, Elsevier Sequoia. |
| مواضيع طبية MeSH: | Parkinson Disease*/genetics , Parkinson Disease*/metabolism, Humans ; Biomarkers/metabolism ; Metabolomics ; Lipid Metabolism ; Metabolic Networks and Pathways |
| مستخلص: | Parkinson's disease (PD) is a widespread neurodegenerative disorder, whose complex aetiology remains under construction. While rare variants have been associated with the monogenic PD form, most PD cases are influenced by multiple genetic and environmental aspects. Nonetheless, the pathophysiological pathways and molecular networks involved in monogenic/idiopathic PD overlap, and genetic variants are decisive in elucidating the convergent underlying mechanisms of PD. In this scenario, metabolomics has furnished a dynamic and systematic picture of the synergy between the genetic background and environmental influences that impact PD, making it a valuable tool for investigating PD-related metabolic dysfunctions. In this review, we performed a brief overview of metabolomics current research in PD, focusing on significant metabolic alterations observed in idiopathic PD from different biofluids and strata and exploring how they relate to genetic factors associated with monogenic PD. Dysregulated amino acid metabolism, lipid metabolism, and oxidative stress are the critical metabolic pathways implicated in both genetic and idiopathic PD. By merging metabolomics and genetics data, it is possible to distinguish metabolic signatures of specific genetic backgrounds and to pinpoint subgroups of PD patients who could derive personalized therapeutic benefits. This approach holds great promise for advancing PD research and developing innovative, cost-effective treatments. Competing Interests: Declaration of Competing Interest The authors declare no conflicts of interest. (Copyright © 2023 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Biomarkers; Diagnostics; Metabolomics; Parkinson’s disease; Personalized therapy |
| المشرفين على المادة: | 0 (Biomarkers) |
| تواريخ الأحداث: | Date Created: 20230925 Date Completed: 20231216 Latest Revision: 20231216 |
| رمز التحديث: | 20231217 |
| DOI: | 10.1016/j.mad.2023.111875 |
| PMID: | 37748695 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1872-6216 |
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| DOI: | 10.1016/j.mad.2023.111875 |