دورية أكاديمية
Gross and Histologic Placental Abnormalities Associated With Neonatal Hypoxic-Ischemic Encephalopathy.
| العنوان: | Gross and Histologic Placental Abnormalities Associated With Neonatal Hypoxic-Ischemic Encephalopathy. |
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| المؤلفون: | Kim CF; Department of Pathology, Boston Children's Hospital, Boston, MA, USA.; Department of Pathology and Immunology, Texas Children's Hospital, Houston, TX, USA., Carreon CK; Department of Pathology, Boston Children's Hospital, Boston, MA, USA.; Department of Pathology, Harvard Medical School, Boston, MA, USA., James KE; Department of Obstetrics, Gynecology, and Reproductive Biology, Massachusetts General Hospital, Boston, MA, USA., Bates SV; Department of Neonatology and Newborn Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA., Mueller SB; Department of Pathology, Harvard Medical School, Boston, MA, USA.; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA., Boyd TK; Department of Pathology, Boston Children's Hospital, Boston, MA, USA.; Department of Pathology and Immunology, Texas Children's Hospital, Houston, TX, USA., Roberts DJ; Department of Pathology, Harvard Medical School, Boston, MA, USA.; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA. |
| المصدر: | Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society [Pediatr Dev Pathol] 2024 Mar-Apr; Vol. 27 (2), pp. 123-131. Date of Electronic Publication: 2023 Sep 25. |
| نوع المنشور: | Journal Article; Multicenter Study |
| اللغة: | English |
| بيانات الدورية: | Publisher: SAGE Publishing Country of Publication: United States NLM ID: 9809673 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1615-5742 (Electronic) Linking ISSN: 10935266 NLM ISO Abbreviation: Pediatr Dev Pathol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2017-: Thousand Oaks, CA : SAGE Publishing Original Publication: New York, NY : Springer, c1998- |
| مواضيع طبية MeSH: | Hypoxia-Ischemia, Brain*/pathology , Placenta Diseases*/pathology, Female ; Humans ; Infant, Newborn ; Pregnancy ; Amniotic Fluid ; Case-Control Studies ; Placenta/pathology ; Retrospective Studies |
| مستخلص: | Objective: To elucidate particular placental pathology findings that are associated with hypoxic ischemic encephalopathy (HIE) and determine which patterns are associated with adverse fetal/neonatal outcomes. Study Design: Multi-institutional retrospective case-control study of newborns with HIE (2002-2022) and controls. Four perinatal pathologists performed gross and histologic evaluation of placentas of cases and controls. Results: A total of 265 placentas of neonates with HIE and 122 controls were examined. Infants with HIE were more likely to have anatomic umbilical cord abnormalities (19.7% vs 7.4%, P = .003), fetal inflammatory response in the setting of amniotic fluid infection (27.7% vs 13.9%, P = .004), and fetal vascular malperfusion (30.6% vs 9.0%, P = <.001) versus controls. Fetal vascular malperfusion with maternal vascular malperfusion was more common in those who died of disease ( P = .01). Conclusion: Placental pathology examination of neonates with HIE may improve our understanding of this disorder and its adverse outcomes. Competing Interests: Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. |
| فهرسة مساهمة: | Keywords: amniotic fluid infection; fetal vascular malperfusion; hypoxic-ischemic encephalopathy; placental pathology; umbilical cord abnormalities |
| تواريخ الأحداث: | Date Created: 20230925 Date Completed: 20240415 Latest Revision: 20240426 |
| رمز التحديث: | 20240427 |
| DOI: | 10.1177/10935266231195166 |
| PMID: | 37749054 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1615-5742 |
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| DOI: | 10.1177/10935266231195166 |