دورية أكاديمية
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Autophagy, a critical element in the aging male reproductive disorders and prostate cancer: a therapeutic point of view.

التفاصيل البيبلوغرافية
العنوان: Autophagy, a critical element in the aging male reproductive disorders and prostate cancer: a therapeutic point of view.
المؤلفون: Raee P; Student Research Committee, Department of Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Tan SC; UKM Medical Molecular Biology Institute, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia., Najafi S; Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, 19395-4719, Iran., Zandsalimi F; Department of Molecular Medicine, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran., Low TY; UKM Medical Molecular Biology Institute, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia., Aghamiri S; Student Research Committee, Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.; Cellular and Molecular Biology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Fazeli E; Mehr Fertility Research Center, Guilan University of Medical Sciences, Rasht, Iran., Aghapour M; Department of Dermatology and Allergic Diseases, Ulm University, Ulm, Germany., Mofarahe ZS; Department of Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Heidari MH; Department of Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Fathabadi FF; Department of Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Abdi F; Department of Chemical Engineering, Science and Research branch, Islamic Azad University, Tehran, Iran., Asouri M; North Research Center, Pasteur Institute of Iran, Amol, Iran., Ahmadi AA; North Research Center, Pasteur Institute of Iran, Amol, Iran., Ghanbarian H; Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, 19395-4719, Iran. hghanbarian@sbmu.ac.ir.; Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. hghanbarian@sbmu.ac.ir.
المصدر: Reproductive biology and endocrinology : RB&E [Reprod Biol Endocrinol] 2023 Sep 26; Vol. 21 (1), pp. 88. Date of Electronic Publication: 2023 Sep 26.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101153627 Publication Model: Electronic Cited Medium: Internet ISSN: 1477-7827 (Electronic) Linking ISSN: 14777827 NLM ISO Abbreviation: Reprod Biol Endocrinol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, 2003-
مواضيع طبية MeSH: Prostatic Neoplasms* , Erectile Dysfunction*, Humans ; Male ; Semen ; Autophagy ; Aging
مستخلص: Autophagy is a highly conserved, lysosome-dependent biological mechanism involved in the degradation and recycling of cellular components. There is growing evidence that autophagy is related to male reproductive biology, particularly spermatogenic and endocrinologic processes closely associated with male sexual and reproductive health. In recent decades, problems such as decreasing sperm count, erectile dysfunction, and infertility have worsened. In addition, reproductive health is closely related to overall health and comorbidity in aging men. In this review, we will outline the role of autophagy as a new player in aging male reproductive dysfunction and prostate cancer. We first provide an overview of the mechanisms of autophagy and its role in regulating male reproductive cells. We then focus on the link between autophagy and aging-related diseases. This is followed by a discussion of therapeutic strategies targeting autophagy before we end with limitations of current studies and suggestions for future developments in the field.
(© 2023. BioMed Central Ltd., part of Springer Nature.)
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فهرسة مساهمة: Keywords: Aging; Autophagy; Erectile dysfunction; Inflammaging; Male infertility; Prostate cancer
تواريخ الأحداث: Date Created: 20230925 Date Completed: 20230927 Latest Revision: 20231121
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10521554
DOI: 10.1186/s12958-023-01134-1
PMID: 37749573
قاعدة البيانات: MEDLINE
الوصف
تدمد:1477-7827
DOI:10.1186/s12958-023-01134-1