دورية أكاديمية
Recombinant antigen delivery to dendritic cells as a way to improve vaccine design.
العنوان: | Recombinant antigen delivery to dendritic cells as a way to improve vaccine design. |
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المؤلفون: | de Souza-Silva GA; Departamento de Parasitologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, 05508-000, Brazil., Sulczewski FB; Departamento de Parasitologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, 05508-000, Brazil., Boscardin SB; Departamento de Parasitologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, 05508-000, Brazil.; Instituto de Investigação em Imunologia (iii), Instituto Nacional de Ciência e Tecnologia, São Paulo, 05401-350, Brazil. |
المصدر: | Experimental biology and medicine (Maywood, N.J.) [Exp Biol Med (Maywood)] 2023 Oct; Vol. 248 (19), pp. 1616-1623. Date of Electronic Publication: 2023 Sep 25. |
نوع المنشور: | Journal Article; Review; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 100973463 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1535-3699 (Electronic) Linking ISSN: 15353699 NLM ISO Abbreviation: Exp Biol Med (Maywood) Subsets: MEDLINE |
أسماء مطبوعة: | Publication: 2024- : Lausanne, Switzerland : Frontiers Media S.A. Original Publication: Maywood, NJ : The Society, c2001- |
مواضيع طبية MeSH: | Vaccines*, Receptors, Cell Surface/metabolism ; Lectins, C-Type/metabolism ; Antibodies, Monoclonal ; Dendritic Cells |
مستخلص: | Dendritic cells are central to the development of immunity, as they are specialized in initiating antigen-specific immune responses. In this review, we briefly present the existing knowledge on dendritic cell biology and how their division in different dendritic cell subsets may impact the development of immune responses. In addition, we explore the use of chimeric monoclonal antibodies that bind to dendritic cell surface receptors, with an emphasis on the C-type lectin family of endocytic receptors, to deliver antigens directly to these cells. Promising preclinical studies have shown that it is possible to modulate the development of immune responses to different pathogens when monoclonal antibodies fused to pathogen-derived antigens are used to deliver the antigen to different subsets of dendritic cells. This approach can be used to improve the efficacy of vaccines against different pathogens. Competing Interests: Declaration Of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. |
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فهرسة مساهمة: | Keywords: B cell response; Dendritic cell; T cell response; antigen targeting; monoclonal antibody; vaccination |
المشرفين على المادة: | 0 (Vaccines) 0 (Receptors, Cell Surface) 0 (Lectins, C-Type) 0 (Antibodies, Monoclonal) |
تواريخ الأحداث: | Date Created: 20230926 Date Completed: 20231216 Latest Revision: 20240326 |
رمز التحديث: | 20240326 |
مُعرف محوري في PubMed: | PMC10723026 |
DOI: | 10.1177/15353702231191185 |
PMID: | 37750021 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1535-3699 |
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DOI: | 10.1177/15353702231191185 |