دورية أكاديمية
Exploring the direct and indirect effects of cardiovascular disease risk factors on exercise blood pressure.
| العنوان: | Exploring the direct and indirect effects of cardiovascular disease risk factors on exercise blood pressure. |
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| المؤلفون: | Moore MN; Menzies Institute for Medical Research, College of Health and Medicine, University of Tasmania, Hobart, Australia., Blizzard CL; Menzies Institute for Medical Research, College of Health and Medicine, University of Tasmania, Hobart, Australia., Dwyer T; Menzies Institute for Medical Research, College of Health and Medicine, University of Tasmania, Hobart, Australia.; George Institute for Global Health, Oxford Martin School and Nuffield Department of Obstetrics & Gynaecology, Oxford University, Oxford, UK.; Murdoch Children's Research Institute, Melbourne, Australia.; Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, Australia., Magnussen CG; Menzies Institute for Medical Research, College of Health and Medicine, University of Tasmania, Hobart, Australia.; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.; Baker Heart and Diabetes Institute, Melbourne, Australia., Sharman JE; Menzies Institute for Medical Research, College of Health and Medicine, University of Tasmania, Hobart, Australia., Venn AJ; Menzies Institute for Medical Research, College of Health and Medicine, University of Tasmania, Hobart, Australia., Schultz MG; Menzies Institute for Medical Research, College of Health and Medicine, University of Tasmania, Hobart, Australia. |
| المصدر: | Scandinavian journal of medicine & science in sports [Scand J Med Sci Sports] 2023 Dec; Vol. 33 (12), pp. 2509-2515. Date of Electronic Publication: 2023 Sep 25. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Munksgaard International Publishers Country of Publication: Denmark NLM ID: 9111504 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-0838 (Electronic) Linking ISSN: 09057188 NLM ISO Abbreviation: Scand J Med Sci Sports Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Copenhagen : Munksgaard International Publishers Original Publication: Copenhagen : Munksgaard, c1991- |
| مواضيع طبية MeSH: | Cardiovascular Diseases*/epidemiology , Cardiovascular Diseases*/etiology , Hypertension*/epidemiology, Adult ; Humans ; Male ; Child ; Female ; Blood Pressure/physiology ; Cross-Sectional Studies ; Risk Factors ; Exercise/physiology |
| مستخلص: | Objective: Exaggerated exercise blood pressure (BP) is independently associated with cardiovascular disease (CVD) outcomes. However, it is unknown how individual CVD risk factors may interact with one another to influence exercise BP. The aim of this study was to quantify direct and indirect associations between CVD risk factors and exercise BP, to determine what CVD risk factor/s most-strongly relate to exercise BP. Methods: In a cross-sectional design, 660 participants (44 ± 2.6 years, 54% male) from the population-based Childhood Determinants of Adult Health Study had BP measured during low-intensity fixed-workload cycling. CVD risk factors were measured, including body composition, clinic (rest) BP, blood biomarkers, and cardiorespiratory fitness. Associations between CVD risk factors and exercise BP were assessed using linear regression, with direct and indirect pathways of association assessed via structural equation model. Results: Sex, waist-to-hip ratio, fitness, and clinic BP were independently associated with exercise systolic BP (SBP), and along with age, had direct associations with exercise SBP (p < 0.05 all). Most CVD risk factors were indirectly associated with exercise SBP via a relation with clinic BP (p < 0.05 all). Clinic BP, waist-to-hip ratio, and fitness were most-strongly associated (direct and indirect association) with exercise SBP (β[95% CI]: 9.35 [8.04, 10.67], 4.91 [2.56, 7.26], and -2.88 [-4.25, -1.51] mm Hg/SD, respectively). Conclusion: Many CVD risk factors are associated with exercise BP, mostly with indirect effects via clinic BP. Clinic BP, body composition, and fitness were most-strongly associated with exercise BP. These results may elucidate how lifestyle modification could be a primary strategy to decrease exaggerated exercise BP-related CVD risk. (© 2023 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.) |
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| معلومات مُعتمدة: | National Health and Medical Research Council |
| فهرسة مساهمة: | Keywords: cardiopulmonary; cohort; epidemiology; hemodynamic; hypertension; physiology |
| تواريخ الأحداث: | Date Created: 20230926 Date Completed: 20231120 Latest Revision: 20231120 |
| رمز التحديث: | 20231120 |
| DOI: | 10.1111/sms.14480 |
| PMID: | 37750022 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1600-0838 |
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| DOI: | 10.1111/sms.14480 |