دورية أكاديمية
Evidence-Based Management of Chronic Lymphocytic Leukemia: Consensus Statements from the Gulf Region.
| العنوان: | Evidence-Based Management of Chronic Lymphocytic Leukemia: Consensus Statements from the Gulf Region. |
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| المؤلفون: | Alshemmari SH; Department of Medicine, Faculty of Medicine and Department of Hematology, Kuwait Cancer Control Centre, Shuwaikh, Kuwait., Siddiqui MA; Hematology and Oncology Division, Sheikh Shakhbout Medical City, Abu Dhabi, United Arab Emirates.; Mayo Clinic Division of Hematology, Rochester, Minnesota, USA., Pandita R; Department of Hematology, Kuwait Cancer Control Centre, Shuwaikh, Kuwait., Osman HY; Oncology Department, Tawam Hospital, Al Ain, United Arab Emirates., Cherif H; Departmant of Hematology, National Center for Cancer Care and Research, Hamad Medical Corporation, Doha, Qatar., O'Brien S; Chao Family Comprehensive Cancer Center, University of California Irvine, Irvine, California, USA., Marashi M; Department of Hematology, Dubai Healthcare Authority, Dubai, United Arab Emirates., Al Farsi K; Department of Hematology, Sultan Qaboos University Hospital Muscat, Seeb, Oman. |
| المصدر: | Acta haematologica [Acta Haematol] 2024; Vol. 147 (3), pp. 260-279. Date of Electronic Publication: 2023 Sep 26. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Karger Country of Publication: Switzerland NLM ID: 0141053 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1421-9662 (Electronic) Linking ISSN: 00015792 NLM ISO Abbreviation: Acta Haematol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel, Karger. |
| مواضيع طبية MeSH: | Leukemia, Lymphocytic, Chronic, B-Cell*/therapy , Leukemia, Lymphocytic, Chronic, B-Cell*/diagnosis , Consensus*, Humans ; Prognosis ; COVID-19/therapy ; Disease Management ; Neoplasm Staging ; Delphi Technique |
| مستخلص: | Introduction: Despite recent advances in diagnosis, prognostication, and treatment options, chronic lymphocytic leukemia (CLL) is still a largely incurable disease. New concepts on diagnosis, staging, treatment, and follow-up on CLL have been incorporated throughout recent years. The lack of regional consensus guidelines has led to varying practices in the management of patients with CLL in the region. This manuscript aims to reach a consensus among expert hematologists regarding the definitions, classifications, and related practices of CLL. The experts developed a set of statements utilizing their personal experience together with the current literature on CLL management. This consensus aims to provide guidance for healthcare professionals involved in the management of CLL and serves as a step in developing regional guidelines. Methods: Eight experts responded to 50 statements regarding the diagnosis, staging, treatment, and prognosis of CLL with three potential answering alternatives ranging between agree, disagree, and abstain. This consensus adopted a modified Delphi consensus methodology. A consensus was reached when at least 75% of the agreement to the answer was reached. This manuscript presents the scientific insights of the participating attendees, panel discussions, and the supporting literature review. Results: Of the 50 statements, a consensus was reached on almost all statements. Statements covered CLL-related topics, including diagnostic evaluation, staging, risk assessment, different patient profiles, prognostic evaluation, treatment decisions, therapy sequences, response evaluation, complications, and CLL during the COVID-19 pandemic. Conclusion: In recent years, CLL management has progressed significantly, with many diagnostic tests and several novel treatments becoming available. This consensus gathers decades of consolidated principles, novel research, and promising prospects for the management of this disease. (© 2023 S. Karger AG, Basel.) |
| فهرسة مساهمة: | Keywords: Chemoimmunotherapy; Chronic lymphocytic leukemia; Delphi; GCC; Gulf; Targeted therapy |
| تواريخ الأحداث: | Date Created: 20230926 Date Completed: 20240528 Latest Revision: 20240830 |
| رمز التحديث: | 20240830 |
| DOI: | 10.1159/000531675 |
| PMID: | 37751733 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1421-9662 |
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| DOI: | 10.1159/000531675 |