دورية أكاديمية
Bilosomes as Nanocarriers for the Drug and Vaccine Delivery against Gastrointestinal Infections: Opportunities and Challenges.
العنوان: | Bilosomes as Nanocarriers for the Drug and Vaccine Delivery against Gastrointestinal Infections: Opportunities and Challenges. |
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المؤلفون: | Zarenezhad E; Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa P.O. Box 7461686688, Iran., Marzi M; Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa P.O. Box 7461686688, Iran., Abdulabbas HT; Department of Medical Microbiology, Medical College, Al Muthanna University, Al Muthanna P.O. Box 07835544777, Iraq., Jasim SA; College of Applied Science, University of Fallujah, Fallujah, Anbar 31002, Iraq., Kouhpayeh SA; Department of Pharmacology, Faculty of Medicine, Fasa University of Medical Sciences, Fasa P.O. Box 7461686688, Iran., Barbaresi S; Department of Movement and Sports Sciences, Ghent University, 9000 Ghent, Belgium., Ahmadi S; Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa P.O. Box 7461686688, Iran., Ghasemian A; Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa P.O. Box 7461686688, Iran. |
المصدر: | Journal of functional biomaterials [J Funct Biomater] 2023 Sep 01; Vol. 14 (9). Date of Electronic Publication: 2023 Sep 01. |
نوع المنشور: | Journal Article; Review |
اللغة: | English |
بيانات الدورية: | Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101570734 Publication Model: Electronic Cited Medium: Print ISSN: 2079-4983 (Print) Linking ISSN: 20794983 NLM ISO Abbreviation: J Funct Biomater Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: Basel : MDPI AG |
مستخلص: | The gastrointestinal tract (GIT) environment has an intricate and complex nature, limiting drugs' stability, oral bioavailability, and adsorption. Additionally, due to the drugs' toxicity and side effects, renders are continuously seeking novel delivery systems. Lipid-based drug delivery vesicles have shown various loading capacities and high stability levels within the GIT. Indeed, most vesicular platforms fail to efficiently deliver drugs toward this route. Notably, the stability of vesicular constructs is different based on the different ingredients added. A low GIT stability of liposomes and niosomes and a low loading capacity of exosomes in drug delivery have been described in the literature. Bilosomes are nonionic, amphiphilic, flexible surfactant vehicles that contain bile salts for the improvement of drug and vaccine delivery. The bilosomes' stability and plasticity in the GIT facilitate the efficient carriage of drugs (such as antimicrobial, antiparasitic, and antifungal drugs), vaccines, and bioactive compounds to treat infectious agents. Considering the intricate and harsh nature of the GIT, bilosomal formulations of oral substances have a remarkably enhanced delivery efficiency, overcoming these conditions. This review aimed to evaluate the potential of bilosomes as drug delivery platforms for antimicrobial, antiviral, antifungal, and antiparasitic GIT-associated drugs and vaccines. |
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فهرسة مساهمة: | Keywords: bilosomes; drug delivery; gastrointestinal infections; vaccines |
تواريخ الأحداث: | Date Created: 20230927 Latest Revision: 20231003 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC10531812 |
DOI: | 10.3390/jfb14090453 |
PMID: | 37754867 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2079-4983 |
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DOI: | 10.3390/jfb14090453 |