دورية أكاديمية
أعرض في EDS

Genetic risk score in multiple sclerosis is associated with unique gut microbiome.

التفاصيل البيبلوغرافية
العنوان: Genetic risk score in multiple sclerosis is associated with unique gut microbiome.
المؤلفون: Elsayed NS; Center for Precision Medicine Research, Marshfield Clinic Research Institute, 1000 N Oak Avenue # MLR, Marshfield, WI, 54449, USA.; Department of Pediatrics, Albert Einstein Medical College, New York, United States., Valenzuela RK; Center for Precision Medicine Research, Marshfield Clinic Research Institute, 1000 N Oak Avenue # MLR, Marshfield, WI, 54449, USA., Kitchner T; Center for Precision Medicine Research, Marshfield Clinic Research Institute, 1000 N Oak Avenue # MLR, Marshfield, WI, 54449, USA., Le T; Integrated Research Development Laboratory, Marshfield Clinic Research Institute, Marshfield Clinic Health System, Marshfield, WI, 54449, USA., Mayer J; Office of Research Computing and Analytics, Marshfield Clinic Research Institute, Marshfield Clinic Health System, Marshfield, WI, 54449, USA., Tang ZZ; Department of Biostatistics and Medical Informatics, University of Wisconsin, Madison, WI, USA., Bayanagari VR; Center for Precision Medicine Research, Marshfield Clinic Research Institute, 1000 N Oak Avenue # MLR, Marshfield, WI, 54449, USA.; Roger Williams Medical Center, Boston University School of Medicine, Providence, RI, 02908, USA., Lu Q; Department of Biostatistics and Medical Informatics, University of Wisconsin, Madison, WI, USA., Aston P; Department of Neurology, Marshfield Clinic Health System, Marshfield, WI, 54449, USA., Anantharaman K; Department of Bacteriology, University of Wisconsin-Madison, Madison, WI, 53706, USA., Shukla SK; Center for Precision Medicine Research, Marshfield Clinic Research Institute, 1000 N Oak Avenue # MLR, Marshfield, WI, 54449, USA. shukla.sanjay@mcrf.mfldclin.edu.; Computational and Informatics in Biology and Medicine Program, University of Wisconsin-Madison, Madison, WI, 53706, USA. shukla.sanjay@mcrf.mfldclin.edu.
المصدر: Scientific reports [Sci Rep] 2023 Sep 27; Vol. 13 (1), pp. 16269. Date of Electronic Publication: 2023 Sep 27.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Gastrointestinal Microbiome*/genetics , Multiple Sclerosis*/genetics, Humans ; Dysbiosis/genetics ; Genetic Predisposition to Disease ; RNA, Ribosomal, 16S/genetics ; Risk Factors
مستخلص: Multiple sclerosis (MS) is a complex autoimmune disease in which both the roles of genetic susceptibility and environmental/microbial factors have been investigated. More than 200 genetic susceptibility variants have been identified along with the dysbiosis of gut microbiota, both independently have been shown to be associated with MS. We hypothesize that MS patients harboring genetic susceptibility variants along with gut microbiome dysbiosis are at a greater risk of exhibiting the disease. We investigated the genetic risk score for MS in conjunction with gut microbiota in the same cohort of 117 relapsing remitting MS (RRMS) and 26 healthy controls. DNA samples were genotyped using Illumina's Infinium Immuno array-24 v2 chip followed by calculating genetic risk score and the microbiota was determined by sequencing the V4 hypervariable region of the 16S rRNA gene. We identified two clusters of MS patients, Cluster A and B, both having a higher genetic risk score than the control group. However, the MS cases in cluster B not only had a higher genetic risk score but also showed a distinct gut microbiome than that of cluster A. Interestingly, cluster A which included both healthy control and MS cases had similar gut microbiome composition. This could be due to (i) the non-active state of the disease in that group of MS patients at the time of fecal sample collection and/or (ii) the restoration of the gut microbiome post disease modifying therapy to treat the MS. Our study showed that there seems to be an association between genetic risk score and gut microbiome dysbiosis in triggering the disease in a small cohort of MS patients. The MS Cluster A who have a higher genetic risk score but microbiome profile similar to that of healthy controls could be due to the remitting phase of the disease or due to the effect of disease modifying therapies.
(© 2023. Springer Nature Limited.)
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المشرفين على المادة: 0 (RNA, Ribosomal, 16S)
تواريخ الأحداث: Date Created: 20230927 Date Completed: 20230929 Latest Revision: 20231121
رمز التحديث: 20231121
مُعرف محوري في PubMed: PMC10533555
DOI: 10.1038/s41598-023-43217-4
PMID: 37758833
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-023-43217-4