دورية أكاديمية
Glycolytic shift during West Nile virus infection provides new therapeutic opportunities.
| العنوان: | Glycolytic shift during West Nile virus infection provides new therapeutic opportunities. |
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| المؤلفون: | Mingo-Casas P; Department of Biotechnology, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, Consejo Superior de Investigaciones Científicas (INIA-CSIC), 28040, Madrid, Spain., Blázquez AB; Department of Biotechnology, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, Consejo Superior de Investigaciones Científicas (INIA-CSIC), 28040, Madrid, Spain., Gómez de Cedrón M; Molecular Oncology Group, IMDEA Food Institute, CEI UAM + CSIC, 28049, Madrid, Spain., San-Félix A; Instituto de Quimica Medica (IQM), CSIC, 28006, Madrid, Spain., Molina S; Molecular Oncology Group, IMDEA Food Institute, CEI UAM + CSIC, 28049, Madrid, Spain., Escribano-Romero E; Department of Biotechnology, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, Consejo Superior de Investigaciones Científicas (INIA-CSIC), 28040, Madrid, Spain., Calvo-Pinilla E; Department of Biotechnology, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, Consejo Superior de Investigaciones Científicas (INIA-CSIC), 28040, Madrid, Spain., Jiménez de Oya N; Department of Biotechnology, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, Consejo Superior de Investigaciones Científicas (INIA-CSIC), 28040, Madrid, Spain., Ramírez de Molina A; Molecular Oncology Group, IMDEA Food Institute, CEI UAM + CSIC, 28049, Madrid, Spain., Saiz JC; Department of Biotechnology, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, Consejo Superior de Investigaciones Científicas (INIA-CSIC), 28040, Madrid, Spain., Pérez-Pérez MJ; Instituto de Quimica Medica (IQM), CSIC, 28006, Madrid, Spain., Martín-Acebes MA; Department of Biotechnology, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, Consejo Superior de Investigaciones Científicas (INIA-CSIC), 28040, Madrid, Spain. martin.mangel@inia.csic.es. |
| المصدر: | Journal of neuroinflammation [J Neuroinflammation] 2023 Sep 27; Vol. 20 (1), pp. 217. Date of Electronic Publication: 2023 Sep 27. |
| نوع المنشور: | Meta-Analysis; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: BioMed Central Country of Publication: England NLM ID: 101222974 Publication Model: Electronic Cited Medium: Internet ISSN: 1742-2094 (Electronic) Linking ISSN: 17422094 NLM ISO Abbreviation: J Neuroinflammation Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [London] : BioMed Central, c2004- |
| مواضيع طبية MeSH: | West Nile Fever*, Humans ; Animals ; Mice ; Glycolysis ; Central Nervous System ; Disease Outbreaks ; Gene Expression Profiling |
| مستخلص: | Background: Viral rewiring of host bioenergetics and immunometabolism may provide novel targets for therapeutic interventions against viral infections. Here, we have explored the effect on bioenergetics during the infection with the mosquito-borne flavivirus West Nile virus (WNV), a medically relevant neurotropic pathogen causing outbreaks of meningitis and encephalitis worldwide. Results: A systematic literature search and meta-analysis pointed to a misbalance of glucose homeostasis in the central nervous system of WNV patients. Real-time bioenergetic analyses confirmed upregulation of aerobic glycolysis and a reduction of mitochondrial oxidative phosphorylation during viral replication in cultured cells. Transcriptomics analyses in neural tissues from experimentally infected mice unveiled a glycolytic shift including the upregulation of hexokinases 2 and 3 (Hk2 and Hk3) and pyruvate dehydrogenase kinase 4 (Pdk4). Treatment of infected mice with the Hk inhibitor, 2-deoxy-D-glucose, or the Pdk4 inhibitor, dichloroacetate, alleviated WNV-induced neuroinflammation. Conclusions: These results highlight the importance of host energetic metabolism and specifically glycolysis in WNV infection in vivo. This study provides proof of concept for the druggability of the glycolytic pathway for the future development of therapies to combat WNV pathology. (© 2023. BioMed Central Ltd., part of Springer Nature.) |
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| معلومات مُعتمدة: | PRE2020-093374 Agencia Estatal de Investigación; PID2019-105117RR-C21 Agencia Estatal de Investigación; PID2019-105117RR-C22 Agencia Estatal de Investigación; PID2019-105117RR-C21 Agencia Estatal de Investigación; PID2020-119195RJ-I00 Agencia Estatal de Investigación; PID2019-105117RR-C21 Agencia Estatal de Investigación; PID2019-105117RR-C22 Agencia Estatal de Investigación; PID2019-105117RR-C21 Agencia Estatal de Investigación; NextGenerationEU through CSIC's Global Health Platform (PTI Salud Global) European Commission; NextGenerationEU through CSIC's Global Health Platform (PTI Salud Global) European Commission; NextGenerationEU through CSIC's Global Health Platform (PTI Salud Global) European Commission; NextGenerationEU through CSIC's Global Health Platform (PTI Salud Global) European Commission; NextGenerationEU through CSIC's Global Health Platform (PTI Salud Global) European Commission; NextGenerationEU through CSIC's Global Health Platform (PTI Salud Global) European Commission; NextGenerationEU through CSIC's Global Health Platform (PTI Salud Global) European Commission; NUTRISION-CM/Y2020/BIO-6350 Comunidad de Madrid; NUTRISION-CM/Y2020/BIO-6350 Comunidad de Madrid; NUTRISION-CM/Y2020/BIO-6350 Comunidad de Madrid |
| فهرسة مساهمة: | Keywords: Glycolysis; Immunometabolism; Neuroinflammation; West Nile virus |
| تواريخ الأحداث: | Date Created: 20230927 Date Completed: 20230929 Latest Revision: 20231119 |
| رمز التحديث: | 20231119 |
| مُعرف محوري في PubMed: | PMC10537838 |
| DOI: | 10.1186/s12974-023-02899-3 |
| PMID: | 37759218 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1742-2094 |
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| DOI: | 10.1186/s12974-023-02899-3 |