دورية أكاديمية
أعرض في EDS

Testing the Induction of Metritis in Healthy Postpartum Primiparous Cows Challenged with a Cocktail of Bacteria.

التفاصيل البيبلوغرافية
العنوان: Testing the Induction of Metritis in Healthy Postpartum Primiparous Cows Challenged with a Cocktail of Bacteria.
المؤلفون: Silva JCC; Department of Population Medicine and Diagnostic Sciences, Cornell University, Ithaca, NY 14853, USA.; Zoetis Animal Health, Kalamazoo, MI 49007, USA., Bringhenti L; Department of Population Medicine and Diagnostic Sciences, Cornell University, Ithaca, NY 14853, USA., Siqueira LC; Department of Population Medicine and Diagnostic Sciences, Cornell University, Ithaca, NY 14853, USA., Rodrigues MX; Department of Population Medicine and Diagnostic Sciences, Cornell University, Ithaca, NY 14853, USA.; FERA Diagnostics and Biologicals, College Station, TX 77845, USA., Zinicola M; Zoetis Animal Health, Kalamazoo, MI 49007, USA., Pomeroy B; Zoetis Animal Health, Kalamazoo, MI 49007, USA., Bicalho RC; Department of Population Medicine and Diagnostic Sciences, Cornell University, Ithaca, NY 14853, USA.; FERA Diagnostics and Biologicals, College Station, TX 77845, USA.
المصدر: Animals : an open access journal from MDPI [Animals (Basel)] 2023 Sep 08; Vol. 13 (18). Date of Electronic Publication: 2023 Sep 08.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Molecular Diversity Preservation International Country of Publication: Switzerland NLM ID: 101635614 Publication Model: Electronic Cited Medium: Print ISSN: 2076-2615 (Print) Linking ISSN: 20762615 NLM ISO Abbreviation: Animals (Basel) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : Molecular Diversity Preservation International, 2011-
مستخلص: Metritis is a postpartum uterine disease with greater incidence in primiparous than in multiparous cows. In primiparous cows, the impact on production and health is lessened, presumably due to a superior immune response. Here, we tested whether an in vivo model of clinical metritis induction developed for postpartum multiparous Holstein cows would produce similar results in primiparous cows. Thirty-six cows were randomly assigned to one of three groups and received intrauterine infusion within 24 h of parturition. The controls were infused with sterile saline; the low-dose group received a bacterial cocktail containing 10 3 cfu of Escherichia coli , Trueperella pyogenes , and Fusobacterium necrophorum ; and the high-dose group were infused with 10 6 cfu of the same cocktail. Production, health traits, and the vaginal discharge culture were assessed daily, from enrollment until 14 d in milk. Clinical metritis occurred in 64% of high-dose cows, 33% of the controls, and 42% of low-dose cows, with no significant difference of incidence between groups. However, when accounting by time, high-dose cows had a 2.7 times greater hazard of metritis compared with the controls. The bacterial challenge affected milk production and dry matter intake tended to decrease. In the high-dose group, a greater growth of F. necrophorum in the selective medium was also observed, suggesting an association with metritis. Therefore, this study suggests intrauterine inoculation with 10 6 cfu of this bacterial cocktail elicits physical and clinical outcomes consistent with clinical metritis.
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فهرسة مساهمة: Keywords: challenge; dairy cow; metritis; microbiota; primiparous
تواريخ الأحداث: Date Created: 20230928 Latest Revision: 20230930
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC10525343
DOI: 10.3390/ani13182852
PMID: 37760254
قاعدة البيانات: MEDLINE
الوصف
تدمد:2076-2615
DOI:10.3390/ani13182852