دورية أكاديمية
أعرض في EDS

Peptide Stapling Applied to Antimicrobial Peptides.

التفاصيل البيبلوغرافية
العنوان: Peptide Stapling Applied to Antimicrobial Peptides.
المؤلفون: Lourenço ALP; Programa de Pós-Graduação em Ciências Genômicas e Biotecnologia, Universidade Católica de Brasília, Brasília 71966-700, Brazil., Rios TB; Programa de Pós-Graduação em Ciências Genômicas e Biotecnologia, Universidade Católica de Brasília, Brasília 71966-700, Brazil.; S-Inova Biotech, Pós-Graduação em Biotecnologia, Universidade Católica Dom Bosco, Campo Grande 79117-900, Brazil., da Silva ÁP; Programa de Pós-Graduação em Ciências Genômicas e Biotecnologia, Universidade Católica de Brasília, Brasília 71966-700, Brazil., Franco OL; Programa de Pós-Graduação em Ciências Genômicas e Biotecnologia, Universidade Católica de Brasília, Brasília 71966-700, Brazil.; S-Inova Biotech, Pós-Graduação em Biotecnologia, Universidade Católica Dom Bosco, Campo Grande 79117-900, Brazil., Ramada MHS; Programa de Pós-Graduação em Ciências Genômicas e Biotecnologia, Universidade Católica de Brasília, Brasília 71966-700, Brazil.; Programa de Pós-Graduação em Gerontologia, Universidade Católica de Brasília, Brasília 71966-700, Brazil.
المصدر: Antibiotics (Basel, Switzerland) [Antibiotics (Basel)] 2023 Sep 02; Vol. 12 (9). Date of Electronic Publication: 2023 Sep 02.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101637404 Publication Model: Electronic Cited Medium: Print ISSN: 2079-6382 (Print) Linking ISSN: 20796382 NLM ISO Abbreviation: Antibiotics (Basel) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI AG, 2012-
مستخلص: Antimicrobial peptides (AMPs) are considered a promising therapeutic approach against multi-drug resistant microorganisms. Besides their advantages, there are limitations to be overcome so that these molecules can become market competitive. One of the biggest limitations is proteolytic susceptibility, which could be overcome by structural modifications such as cyclization, especially for helix-constraining strategies. Over the years, many helix stabilization techniques have arisen, such as lactam-bridging, triazole-based, N-alkylation and all-hydrocarbon stapling. All-hydrocarbon stapling takes advantage of modified amino acid residues and olefinic cross-linking to constrain peptide helices. Despite being a well-established strategy and presenting efficient stability results, there are different limitations especially related to toxicity. In this review, recent studies on stapled AMPs for antimicrobial usage are explored with the aim of understanding the future of these molecules as putative antimicrobial agents.
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معلومات مُعتمدة: 00193.00001055/2021-13 Foundation for Research Support of the Federal District
فهرسة مساهمة: Keywords: all-hydrocarbon stapling; antimicrobial peptides; cyclization; stapling
تواريخ الأحداث: Date Created: 20230928 Latest Revision: 20231003
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10525709
DOI: 10.3390/antibiotics12091400
PMID: 37760697
قاعدة البيانات: MEDLINE
الوصف
تدمد:2079-6382
DOI:10.3390/antibiotics12091400