دورية أكاديمية
Non-Targeted Screening of Metabolites in Aqueous-Ethanol Extract from Spiraea hypericifolia (Rosaceae) Using LC-HRMS.
العنوان: | Non-Targeted Screening of Metabolites in Aqueous-Ethanol Extract from Spiraea hypericifolia (Rosaceae) Using LC-HRMS. |
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المؤلفون: | Kostikova VA; Central Siberian Botanical Garden, Siberian Branch, Russian Academy of Sciences (SB RAS), Novosibirsk 630090, Russia., Petrova NV; Komarov Botanical Institute, Russian Academy of Sciences, St. Petersburg 197022, Russia., Shaldaeva TM; Central Siberian Botanical Garden, Siberian Branch, Russian Academy of Sciences (SB RAS), Novosibirsk 630090, Russia., Koval VV; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences (SB RAS), Novosibirsk 630090, Russia., Chernonosov AA; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences (SB RAS), Novosibirsk 630090, Russia. |
المصدر: | International journal of molecular sciences [Int J Mol Sci] 2023 Sep 08; Vol. 24 (18). Date of Electronic Publication: 2023 Sep 08. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI, [2000- |
مواضيع طبية MeSH: | Spiraea* , Rosaceae* , Catechin*, Quercetin ; Flavonoids ; Plant Extracts/pharmacology |
مستخلص: | By means of liquid chromatography combined with high-resolution mass spectrometry, metabolite profiling was performed on an aqueous-ethanol extract from Spiraea hypericifolia (Rosaceae) collected in Siberia (Russia). Up to 140 compounds were found in the extract, of which 47 were tentatively identified. The identified compounds were amino acids, sugars, phenylpropanoids, fatty acids and their derivatives, triterpenoids, flavonoids, and others. A quantitative analysis showed the predominance of phenolcarboxylic acids and flavonoids in the studied extract, but a qualitative analysis revealed the higher structural diversity of flavonoids. Of the 23 identified flavonoids, 13 were flavonols: quercetin, hyperoside, isoquercitrin, reynoutrin, avicularin, rutin, quercetin-3-O-(6″-O-malonyl)-β-D-glucoside, 3-O-methylquercetin-3'-O-β-D-glucopyranoside, isorhamnetin, rhamnetin-3-O-β-D-xylopyranosyl-β-D-glucopyranoside, kaempferol, tiliroside, and trifolin; six were catechins: catechin, (-)-epicatechin, (+)-epicatechin, (+)-catechin-7-O-β-D-xyloside, (2S,3R)-3,5-dihydroxy-2-(4-hydroxyphenyl)-3,4-dihydro-2H-chromen-7-yl-β-D-glucopyranoside, and catechin 7-O-apiofuranoside; two are isoflavones: genistin and genistein; and one was a flavone (luteolin-4'-O-β-D-glucopyranoside) and another was an anthocyanidin (pelargonidin). The aqueous-ethanol extract from S. hypericifolia showed antioxidant activity (half-maximal inhibitory concentration 102.95 μg/mL), which was likely related to the high concentrations of phenolcarboxylic acids (229.6 mg/g), flavonoids (118.3 mg/g), and tannins (62.9 mg/g). |
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معلومات مُعتمدة: | The work was supported by Russian Science Foundation grant No. 23-24-00310, https://rscf.ru/project/23-24-00310/ The work was supported by Russian Science Foundation grant No. 23-24-00310, https://rscf.ru/project/23-24-00310/ |
فهرسة مساهمة: | Keywords: HPLC; LC-HRMS; Spiraea hypericifolia; antioxidant activity; flavonoid; metabolome |
المشرفين على المادة: | 9IKM0I5T1E (Quercetin) 8R1V1STN48 (Catechin) 0 (Flavonoids) 0 (Plant Extracts) |
تواريخ الأحداث: | Date Created: 20230928 Date Completed: 20230929 Latest Revision: 20231003 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC10530674 |
DOI: | 10.3390/ijms241813872 |
PMID: | 37762175 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1422-0067 |
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DOI: | 10.3390/ijms241813872 |