دورية أكاديمية
أعرض في EDS

BRCA1 the Versatile Defender: Molecular to Environmental Perspectives.

التفاصيل البيبلوغرافية
العنوان: BRCA1 the Versatile Defender: Molecular to Environmental Perspectives.
المؤلفون: Zhong AX; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Chen Y; Department of Medicine, Division of Endocrinology, University of California, Irvine, CA 92697, USA., Chen PL; Department of Biological Chemistry, University of California, Irvine, CA 92697, USA.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2023 Sep 19; Vol. 24 (18). Date of Electronic Publication: 2023 Sep 19.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Breast Neoplasms*/genetics , Ovarian Neoplasms*, Humans ; Female ; BRCA1 Protein/genetics ; Breast ; DNA Repair
مستخلص: The evolving history of BRCA1 research demonstrates the profound interconnectedness of a single protein within the web of crucial functions in human cells. Mutations in BRCA1, a tumor suppressor gene, have been linked to heightened breast and ovarian cancer risks. However, despite decades of extensive research, the mechanisms underlying BRCA1's contribution to tissue-specific tumor development remain elusive. Nevertheless, much of the BRCA1 protein's structure, function, and interactions has been elucidated. Individual regions of BRCA1 interact with numerous proteins to play roles in ubiquitination, transcription, cell checkpoints, and DNA damage repair. At a cellular scale, these BRCA1 functions coordinate tumor suppression, R-loop prevention, and cellular differentiation, all of which may contribute to BRCA1's role in cancer tissue specificity. As research on BRCA1 and breast cancer continues to evolve, it will become increasingly evident that modern materials such as Bisphenol A should be examined for their relationship with DNA stability, cancer incidence, and chemotherapy. Overall, this review offers a comprehensive understanding of BRCA1's many roles at a molecular, cellular, organismal, and environmental scale. We hope that the knowledge gathered here highlights both the necessity of BRCA1 research and the potential for novel strategies to prevent and treat cancer in individuals carrying BRCA1 mutations.
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فهرسة مساهمة: Keywords: BRCA1; BRCT; Bisphenol A; DNA damage repair; RING finger; breast cancer; differentiation; tissue specificity; tumor suppressor gene; ubiquitination
المشرفين على المادة: 0 (BRCA1 Protein)
0 (BRCA1 protein, human)
تواريخ الأحداث: Date Created: 20230928 Date Completed: 20230929 Latest Revision: 20231003
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC10532398
DOI: 10.3390/ijms241814276
PMID: 37762577
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms241814276