دورية أكاديمية
The Protective Effects of Water-Soluble Alginic Acid on the N-Terminal of Thymopentin.
| العنوان: | The Protective Effects of Water-Soluble Alginic Acid on the N-Terminal of Thymopentin. |
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| المؤلفون: | Ji H; Center for Mitochondria and Healthy Aging, College of Life Sciences, Yantai University, Yantai 264005, China., Fan Y; Center for Mitochondria and Healthy Aging, College of Life Sciences, Yantai University, Yantai 264005, China., Gao X; Center for Mitochondria and Healthy Aging, College of Life Sciences, Yantai University, Yantai 264005, China., Gong Y; Center for Mitochondria and Healthy Aging, College of Life Sciences, Yantai University, Yantai 264005, China., Dai K; College of Food Science and Engineering, Tianjin University of Science and Technology, Tianjin 300457, China., Wang Z; Center for Mitochondria and Healthy Aging, College of Life Sciences, Yantai University, Yantai 264005, China., Xu B; Center for Mitochondria and Healthy Aging, College of Life Sciences, Yantai University, Yantai 264005, China., Yu J; Center for Mitochondria and Healthy Aging, College of Life Sciences, Yantai University, Yantai 264005, China. |
| المصدر: | Molecules (Basel, Switzerland) [Molecules] 2023 Sep 05; Vol. 28 (18). Date of Electronic Publication: 2023 Sep 05. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI, c1995- |
| مواضيع طبية MeSH: | Thymopentin*/pharmacology , Thymopentin*/metabolism , Alginic Acid*, Humans ; Mice ; Animals ; Adjuvants, Immunologic/pharmacology ; T-Lymphocytes/metabolism ; Thymus Gland/metabolism |
| مستخلص: | Thymopentin (TP5) has exhibited strong antitumor and immunomodulatory effects in vivo. However, the polypeptide is rapidly degraded by protease and aminopeptidase within a minute at the N-terminal of TP5, resulting in severe limitations for further practical applications. In this study, the protective effects of water-soluble alginic acid (WSAA) on the N-terminal of TP5 were investigated by establishing an H22 tumor-bearing mice model and determining thymus, spleen, and liver indices, immune cells activities, TNF-α, IFN-γ, IL-2, and IL-4 levels, and cell cycle distributions. The results demonstrated that WSAA+TP5 groups exhibited the obvious advantages of the individual treatments and showed superior antitumor effects on H22 tumor-bearing mice by effectively protecting the immune organs, activating CD4 + T cells and CD19 + B cells, and promoting immune-related cytokines secretions, finally resulting in the high apoptotic rates of H22 cells through arresting them in S phase. These data suggest that WSAA could effectively protect the N-terminal of TP5, thereby improving its antitumor and immunoregulatory activities, which indicates that WSAA has the potential to be applied in patients bearing cancer or immune deficiency diseases as a novel immunologic adjuvant. |
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| فهرسة مساهمة: | Keywords: immune potentiation; thymopentin; water-soluble alginic acid |
| المشرفين على المادة: | O3Y80ZF13F (Thymopentin) 8C3Z4148WZ (Alginic Acid) 0 (Adjuvants, Immunologic) |
| تواريخ الأحداث: | Date Created: 20230928 Date Completed: 20231004 Latest Revision: 20231004 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC10536172 |
| DOI: | 10.3390/molecules28186445 |
| PMID: | 37764221 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1420-3049 |
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| DOI: | 10.3390/molecules28186445 |