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Syzygium cumini (L.) Extract-Derived Green Titanium Dioxide Nanoparticles Induce Caspase-Dependent Apoptosis in Hepatic Cancer Cells.

التفاصيل البيبلوغرافية
العنوان: Syzygium cumini (L.) Extract-Derived Green Titanium Dioxide Nanoparticles Induce Caspase-Dependent Apoptosis in Hepatic Cancer Cells.
المؤلفون: Rayzah M; Department of Surgery, College of Medicine, Majmaah University, Al Majmaah 11952, Saudi Arabia., Elderdery AY; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Sakaka 42421, Saudi Arabia., Alzerwi NAN; Department of Surgery, College of Medicine, Majmaah University, Al Majmaah 11952, Saudi Arabia., Alzahrani B; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Sakaka 42421, Saudi Arabia., Alsrhani A; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Sakaka 42421, Saudi Arabia., Alsultan A; Department of Surgery, King Saud Medical City, Riyadh 12746, Saudi Arabia., Idrees B; Department of Surgery, Prince Sultan Military Medical City, As Sulimaniyah 12233, Saudi Arabia., Rayzah F; Aseer Central Hospital, Abha 62523, Saudi Arabia., Bakhsh Y; Iman General Hospital, Riyadh 12211, Saudi Arabia., Alzahrani AM; Department of Surgery, College of Medicine, Majmaah University, Al Majmaah 11952, Saudi Arabia., Subbiah SK; Centre for Materials Engineering and Regenerative Medicine, Bharath Institute of Higher Education and Research, Chennai 600073, India., Mok PL; Department of Biomedical Science, Faculty of Medicine & Health Sciences, Universiti Putra Malaysia, UPM, Serdang 43400, Malaysia.
المصدر: Plants (Basel, Switzerland) [Plants (Basel)] 2023 Sep 05; Vol. 12 (18). Date of Electronic Publication: 2023 Sep 05.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101596181 Publication Model: Electronic Cited Medium: Print ISSN: 2223-7747 (Print) Linking ISSN: 22237747 NLM ISO Abbreviation: Plants (Basel) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI AG, [2012]-
مستخلص: An aqueous extract of Syzygium cumini seeds was utilized to green synthesize titanium dioxide nanoparticles (TiO 2 NPs). UV-Visible, DLS, FTIR, XRD, FESEM, TEM, SAED, EDAX, and photoluminescence spectroscopy techniques were employed to characterize the prepared TiO 2 nanoparticles. The rutile crystal structure of TiO 2 NPs was revealed by XRD study. The TEM and FESEM images of the TiO 2 NPs revealed an average particle size of 50-100 nm. We employed EDAX to investigate the elemental compositions of TiO 2 NPs. The O-Ti-O stretching bands appeared in the FTIR spectrum of TiO 2 NPs at wavenumbers of 495 cm -1 . The absorption edge peaks of TiO 2 NPs were found in the UV-vis spectra at 397 nm. The MTT study revealed that TiO 2 NPs effectively inhibited the growth of liver cancer Hep3 and Hep-G2 cells. The results of the corresponding fluorescent staining assays showed that TiO 2 NPs significantly increased ROS generation, decreased MMP, and induced apoptosis in both liver cancer Hep3 and Hep-G2 cells. TiO 2 nanoparticles lessened SOD, CAT, and GSH levels while augmenting MDA contents in Hep3 and Hep-G2 cells. In both Hep3 and Hep-G2 cells treated with TiO 2 NPs, the Bax, CytC, p53, caspase-3, -8, and -9 expressions were remarkably augmented, while Bcl-2 expression was reduced. Overall, these findings revealed that formulated TiO 2 NPs treatment considerably inhibited growth and triggered apoptosis in Hep3 and HepG2 cells.
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معلومات مُعتمدة: DSR-2021-01-0354 Deanship of Scientific Research at Jouf University
فهرسة مساهمة: Keywords: Syzygium cumini; apoptosis; liver cancer; nanomedicine; titanium oxide
تواريخ الأحداث: Date Created: 20230928 Latest Revision: 20231003
رمز التحديث: 20231003
مُعرف محوري في PubMed: PMC10537597
DOI: 10.3390/plants12183174
PMID: 37765338
قاعدة البيانات: MEDLINE
الوصف
تدمد:2223-7747
DOI:10.3390/plants12183174