دورية أكاديمية
Optimising the Delivery of RHDV to Rabbits for Biocontrol: An Experimental Evaluation of Two Novel Methods of Virus Delivery.
| العنوان: | Optimising the Delivery of RHDV to Rabbits for Biocontrol: An Experimental Evaluation of Two Novel Methods of Virus Delivery. |
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| المؤلفون: | Dorji T; Biosecurity, Department of Primary Industries and Regions (PIRSA), Urrbrae, SA 5064, Australia.; School of Food, Agriculture and Wine, The University of Adelaide, Urrbrae, SA 5064, Australia., Jayasingha Ellakkala Appuhamilage RMJ; Biosecurity, Department of Primary Industries and Regions (PIRSA), Urrbrae, SA 5064, Australia., Bird PL; Waite Conservation Reserve, University of Adelaide, Urrbrae, SA 5064, Australia., Huang N; Health & Biosecurity, Commonwealth Scientific and Industrial Research Organisation, Acton, ACT 2601, Australia., O'Connor TW; Virology Laboratory, Elizabeth Macarthur Agricultural Institute, Department of Primary Industries NSW, Menangle, NSW 2568, Australia., Patel KK; Biosecurity, Department of Primary Industries and Regions (PIRSA), Urrbrae, SA 5064, Australia.; School of Animal and Veterinary Sciences, The University of Adelaide, Roseworthy, SA 5371, Australia., Strive T; Health & Biosecurity, Commonwealth Scientific and Industrial Research Organisation, Acton, ACT 2601, Australia., Taggart PL; School of Animal and Veterinary Sciences, The University of Adelaide, Roseworthy, SA 5371, Australia.; Vertebrate Pest Research Unit, Department of Primary Industries NSW, Queanbeyan, NSW 2620, Australia.; School of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, NSW 2000, Australia. |
| المصدر: | Viruses [Viruses] 2023 Aug 25; Vol. 15 (9). Date of Electronic Publication: 2023 Aug 25. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101509722 Publication Model: Electronic Cited Medium: Internet ISSN: 1999-4915 (Electronic) Linking ISSN: 19994915 NLM ISO Abbreviation: Viruses Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI |
| مواضيع طبية MeSH: | Hemorrhagic Disease Virus, Rabbit*, Rabbits ; Animals ; Australia ; Biological Assay ; Desiccation ; Soil |
| مستخلص: | Rabbit haemorrhagic disease virus (RHDV) is established as a landscape-scale biocontrol that assists the management of invasive European rabbits and their impacts in both Australia and New Zealand. In addition to this, it is also available to land managers to augment rabbit control efforts at a local scale. However, current methods of deploying RHDV to rabbits that rely on the consumption of virus-treated baits can be problematic as rabbits are reluctant to consume bait when there is abundant, green, protein-rich feed available. We ran a suite of interrupted time-series experiments to compare the duration of infectivity of two conventional (carrot and oat baits) and two novel (meat bait and soil burrow spray) methods of deploying RHDV to rabbits. All methods effectively killed exposed rabbits. Soil burrow spray and carrot baits resulted in infection and mortality out to 5 days post their deployment in the field, and meat baits caused infection out to 10 days post their deployment. In contrast, oat baits continued to infect and kill exposed rabbits out to 20 days post deployment. Molecular assays demonstrated high viral loads in deployed baits beyond the duration for which they were infectious or lethal to rabbits. Based on our results, we suggest that the drying of meat baits may create a barrier to effective transmission of RHDV by adult flies within 10 days. We therefore hypothesise that fly larvae production and development on infected tissues is critical to prolonged viral transmission from meat baits, and similarly from carcasses of RHDV mortalities, via mechanical fly vectors. Our study demonstrates that meat baits and soil spray could provide additional virus deployment options that remove the need for rabbits to consume baits at times when they are reluctant to do so. |
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| فهرسة مساهمة: | Keywords: Oryctolagus cuniculus; bait; biological control; rabbit haemorrhagic disease virus; survival |
| المشرفين على المادة: | 0 (Soil) |
| تواريخ الأحداث: | Date Created: 20230928 Date Completed: 20230929 Latest Revision: 20231003 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC10536075 |
| DOI: | 10.3390/v15091814 |
| PMID: | 37766220 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1999-4915 |
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| DOI: | 10.3390/v15091814 |