دورية أكاديمية
أعرض في EDS

High levels of intra-strain structural variation in Drosophila simulans X pericentric heterochromatin.

التفاصيل البيبلوغرافية
العنوان: High levels of intra-strain structural variation in Drosophila simulans X pericentric heterochromatin.
المؤلفون: Courret C; Department of Biology, University of Rochester, Rochester, NY 14627, USA., Larracuente AM; Department of Biology, University of Rochester, Rochester, NY 14627, USA.
المصدر: Genetics [Genetics] 2023 Dec 06; Vol. 225 (4).
نوع المنشور: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
اللغة: English
بيانات الدورية: Publisher: Oxford University Press Country of Publication: United States NLM ID: 0374636 Publication Model: Print Cited Medium: Internet ISSN: 1943-2631 (Electronic) Linking ISSN: 00166731 NLM ISO Abbreviation: Genetics Subsets: MEDLINE
أسماء مطبوعة: Publication: 2021- : [Oxford] : Oxford University Press
Original Publication: Austin, Tex. [etc.]
مواضيع طبية MeSH: Heterochromatin*/genetics , Drosophila simulans*/genetics, Animals ; DNA, Satellite/genetics ; Repetitive Sequences, Nucleic Acid ; Drosophila melanogaster/genetics
مستخلص: Large genome structural variations can impact genome regulation and integrity. Repeat-rich regions like pericentric heterochromatin are vulnerable to structural rearrangements although we know little about how often these rearrangements occur over evolutionary time. Repetitive genome regions are particularly difficult to study with genomic approaches, as they are missing from most genome assemblies. However, cytogenetic approaches offer a direct way to detect large rearrangements involving pericentric heterochromatin. Here, we use a cytogenetic approach to reveal large structural rearrangements associated with the X pericentromeric region of Drosophila simulans. These rearrangements involve large blocks of satellite DNA-the 500-bp and Rsp-like satellites-which colocalize in the X pericentromeric heterochromatin. We find that this region is polymorphic not only among different strains, but between isolates of the same strain from different labs, and even within individual isolates. On the one hand, our observations raise questions regarding the potential impact of such variation at the phenotypic level and our ability to control for such genetic variability. On the other hand, this highlights the very rapid turnover of the pericentric heterochromatin most likely associated with genomic instability of the X pericentromere. It represents a unique opportunity to study the dynamics of pericentric heterochromatin, the evolution of associated satellites on a very short time scale, and to better understand how structural variation arises.
Competing Interests: Conflicts of interest The author(s) declare no conflict of interest.
(© The Author(s) 2023. Published by Oxford University Press on behalf of The Genetics Society of America.)
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فهرسة مساهمة: Keywords: Drosophila; pericentromeric heterochromatin; satellite repeats; structural variation
المشرفين على المادة: 0 (Heterochromatin)
0 (DNA, Satellite)
تواريخ الأحداث: Date Created: 20230928 Date Completed: 20231207 Latest Revision: 20240701
رمز التحديث: 20240701
مُعرف محوري في PubMed: PMC10697818
DOI: 10.1093/genetics/iyad176
PMID: 37768175
قاعدة البيانات: MEDLINE
الوصف
تدمد:1943-2631
DOI:10.1093/genetics/iyad176