دورية أكاديمية
BML-281 promotes neuronal differentiation by modulating Wnt/Ca 2+ and Wnt/PCP signaling pathway.
العنوان: | BML-281 promotes neuronal differentiation by modulating Wnt/Ca 2+ and Wnt/PCP signaling pathway. |
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المؤلفون: | Choi J; Department of Physiology, Chonnam National University Medical School, Jellanamdo, 58128, Republic of Korea., Gang S; Department of Physiology, Chonnam National University Medical School, Jellanamdo, 58128, Republic of Korea.; Department of Pre-Medical Science, Chonnam National University Medical School, Jellanamdo, 58128, Republic of Korea., Ramalingam M; Department of Physiology, Chonnam National University Medical School, Jellanamdo, 58128, Republic of Korea., Hwang J; Department of Physiology, Chonnam National University Medical School, Jellanamdo, 58128, Republic of Korea., Jeong H; Department of Physiology, Chonnam National University Medical School, Jellanamdo, 58128, Republic of Korea., Yoo J; Department of Physiological Education, Chonnam National University, Gwangju, 61186, Republic of Korea., Cho HH; Department of Otolaryngology-Head and Neck Surgery, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, 61469, Republic of Korea., Kim BC; Department of Neurology, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, 61469, Republic of Korea., Jang G; School of Biological Sciences and Technology, Chonnam National University, Gwangju, 61186, Republic of Korea., Jeong HS; Department of Physiology, Chonnam National University Medical School, Jellanamdo, 58128, Republic of Korea. jhsjeong@hanmail.net., Jang S; Department of Physiology, Chonnam National University Medical School, Jellanamdo, 58128, Republic of Korea. sujeong.jjang@gmail.com. |
المصدر: | Molecular and cellular biochemistry [Mol Cell Biochem] 2024 Sep; Vol. 479 (9), pp. 2391-2403. Date of Electronic Publication: 2023 Sep 28. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Springer Country of Publication: Netherlands NLM ID: 0364456 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-4919 (Electronic) Linking ISSN: 03008177 NLM ISO Abbreviation: Mol Cell Biochem Subsets: MEDLINE |
أسماء مطبوعة: | Publication: New York : Springer Original Publication: The Hague, Dr. W. Junk B. V. Publishers. |
مواضيع طبية MeSH: | Cell Differentiation*/drug effects , Wnt Signaling Pathway*/drug effects , Neurons*/metabolism , Neurons*/drug effects , Neurons*/cytology, Humans ; Cell Line, Tumor ; Calcium/metabolism |
مستخلص: | Histone deacetylase (HDAC) inhibitors promote differentiation through post-translational modifications of histones. BML-281, an HDAC6 inhibitor, has been known to prevent tumors, acute dextran sodium sulfate-associated colitis, and lung injury. However, the neurogenic differentiation effect of BML-281 is poorly understood. In this study, we investigated the effect of BML-281 on neuroblastoma SH-SY5Y cell differentiation into mature neurons by immunocytochemistry (ICC), reverse transcriptase PCR (RT-PCR), quantitative PCR (qPCR), and western blotting analysis. We found that the cells treated with BML-281 showed neurite outgrowth and morphological changes into mature neurons under a microscope. It was confirmed that the gene expression of neuronal markers (NEFL, MAP2, Tuj1, NEFH, and NEFM) was increased with certain concentrations of BML-281. Similarly, the protein expression of neuronal markers (NeuN, Synaptophysin, Tuj1, and NFH) was upregulated with BML-281 compared to untreated cells. Following treatment with BML-281, the expression of Wnt5α increased, and downstream pathways were activated. Interestingly, both Wnt/Ca 2+ and Wnt/PCP pathways activated and regulated PKC, Cdc42, RhoA, Rac1/2/3, and p-JNK. Therefore, BML-281 induces the differentiation of SH-SY5Y cells into mature neurons by activating the non-canonical Wnt signaling pathway. From these results, we concluded that BML-281 might be a novel drug to differentiation into neuronal cells through the regulation of Wnt signaling pathway to reduce the neuronal cell death. (© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.) |
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معلومات مُعتمدة: | 2021R1I1A3060435 National Research Foundation of Korea; 2020R1F1A1076616 National Research Foundation of Korea; MOTIE the Korea Institute for Advancement of Technology; BCRI23041 Chonnam National University Hospital Biomedical Research Institute |
فهرسة مساهمة: | Keywords: BML-281; HDAC inhibitor; Neuronal differentiation; Non-canonical wnt signaling pathway; Wnt signaling pathway |
المشرفين على المادة: | SY7Q814VUP (Calcium) |
تواريخ الأحداث: | Date Created: 20230928 Date Completed: 20240903 Latest Revision: 20240903 |
رمز التحديث: | 20240903 |
DOI: | 10.1007/s11010-023-04857-2 |
PMID: | 37768498 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1573-4919 |
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DOI: | 10.1007/s11010-023-04857-2 |