دورية أكاديمية
أعرض في EDS

Mass mortality event in South American sea lions ( Otaria flavescens ) correlated to highly pathogenic avian influenza (HPAI) H5N1 outbreak in Chile.

التفاصيل البيبلوغرافية
العنوان: Mass mortality event in South American sea lions ( Otaria flavescens ) correlated to highly pathogenic avian influenza (HPAI) H5N1 outbreak in Chile.
المؤلفون: Ulloa M; Veterinary Histology and Pathology, Institute of Animal Health and Food Safety, Veterinary School, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.; Servicio Nacional de Pesca y Acuicultura, Valparaíso, Chile., Fernández A; Veterinary Histology and Pathology, Institute of Animal Health and Food Safety, Veterinary School, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain., Ariyama N; Programa de Doctorado en Ciencias Silvoagropecuarias y Veterinarias, Universidad de Chile, Santiago, Chile.; Departamento de Medicina Preventiva Animal, Facultad de Ciencias Veterinarias y Pecuarias, Universidad de Chile, Santiago, Chile., Colom-Rivero A; Veterinary Histology and Pathology, Institute of Animal Health and Food Safety, Veterinary School, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain., Rivera C; Servicio Agrícola y Ganadero, Santiago, Chile., Nuñez P; Servicio Agrícola y Ganadero, Santiago, Chile., Sanhueza P; Servicio Agrícola y Ganadero, Santiago, Chile., Johow M; Servicio Agrícola y Ganadero, Santiago, Chile., Araya H; Servicio Agrícola y Ganadero, Santiago, Chile., Torres JC; Servicio Agrícola y Ganadero, Santiago, Chile., Gomez P; Servicio Nacional de Pesca y Acuicultura, Valparaíso, Chile., Muñoz G; Programa de Doctorado en Ciencias Silvoagropecuarias y Veterinarias, Universidad de Chile, Santiago, Chile.; Departamento de Medicina Preventiva Animal, Facultad de Ciencias Veterinarias y Pecuarias, Universidad de Chile, Santiago, Chile., Agüero B; Programa de Doctorado en Ciencias Silvoagropecuarias y Veterinarias, Universidad de Chile, Santiago, Chile.; Departamento de Medicina Preventiva Animal, Facultad de Ciencias Veterinarias y Pecuarias, Universidad de Chile, Santiago, Chile., Alegría R; Escuela Medicina Veterinaria, Facultad de Recursos Naturales y Medicina Veterinaria, Universidad Santo Tomas, Santiago, Chile., Medina R; School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, GA, USA., Neira V; Departamento de Medicina Preventiva Animal, Facultad de Ciencias Veterinarias y Pecuarias, Universidad de Chile, Santiago, Chile., Sierra E; Veterinary Histology and Pathology, Institute of Animal Health and Food Safety, Veterinary School, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.
المصدر: The veterinary quarterly [Vet Q] 2023 Dec; Vol. 43 (1), pp. 1-10. Date of Electronic Publication: 2023 Oct 19.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Taylor & Francis Country of Publication: England NLM ID: 7909485 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1875-5941 (Electronic) Linking ISSN: 01652176 NLM ISO Abbreviation: Vet Q Subsets: MEDLINE
أسماء مطبوعة: Publication: 2011->: Abingdon, Oxfordshire : Taylor & Francis
Original Publication: The Hague, Boston : Published for the Royal Netherlands Veterinary Assn. by M. Nijhoff.
مواضيع طبية MeSH: Influenza in Birds*/epidemiology , Sea Lions* , Influenza A Virus, H5N1 Subtype*, Animals ; Chile/epidemiology ; Disease Outbreaks/veterinary ; Birds ; Phylogeny
مستخلص: In Chile, since January 2023, a sudden and pronounced increase in strandings and mortality has been observed among South American (SA) sea lions (Otaria flavescens), prompting significant concern. Simultaneously, an outbreak of highly pathogenic avian influenza H5N1 (HPAIV H5N1) in avian species has emerged since December 2022. To investigate the cause of this unexpected mortality, we conducted a comprehensive epidemiological and pathologic study. One hundred sixty-nine SA sea lions were sampled to ascertain their HPAIV H5N1 status, and long-term stranding trends from 2009 to 2023 were analyzed. In addition, two animals were necropsied. Remarkably, a significant surge in SA sea lion strandings was observed initiating in January 2023 and peaking in June 2023, with a count of 4,545 stranded and deceased animals. Notably, this surge in mortality correlates geographically with HPAIV outbreaks affecting wild birds. Among 168 sampled SA sea lions, 34 (20%) tested positive for Influenza A virus, and 21 confirmed for HPAIV H5N1 2.3.4.4b clade in tracheal/rectal swab pools. Clinical and pathological evaluations of the two necropsied stranded sea lions revealed prevalent neurological and respiratory signs, including disorientation, tremors, ataxia, and paralysis, as well as acute dyspnea, tachypnea, profuse nasal secretion, and abdominal breathing. The lesions identified in necropsied animals aligned with observed clinical signs. Detection of the virus via immunohistochemistry (IHC) and real-time PCR in the brain and lungs affirmed the findings. The findings provide evidence between the mass mortality occurrences in SA sea lions and HPAIV, strongly indicating a causal relationship. Further studies are needed to better understand the pathogenesis and transmission.
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معلومات مُعتمدة: 75N93021C00014 United States AI NIAID NIH HHS
فهرسة مساهمة: Keywords: Chile; Mortality; South American sea lions; highly pathogenic avian influenza H5N1; outbreak; strandings
تواريخ الأحداث: Date Created: 20230928 Date Completed: 20231023 Latest Revision: 20240210
رمز التحديث: 20240210
مُعرف محوري في PubMed: PMC10588531
DOI: 10.1080/01652176.2023.2265173
PMID: 37768676
قاعدة البيانات: MEDLINE
الوصف
تدمد:1875-5941
DOI:10.1080/01652176.2023.2265173