دورية أكاديمية
Carboxymethyl chitosan-gelatin-mesoporous silica nanoparticles containing Myrtus communis L. extract as a novel transparent film wound dressing.
| العنوان: | Carboxymethyl chitosan-gelatin-mesoporous silica nanoparticles containing Myrtus communis L. extract as a novel transparent film wound dressing. |
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| المؤلفون: | Haririan Y; Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran., Asefnejad A; Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran. Electronic address: asefnejad@srbiau.ac.ir., Hamishehkar H; Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran., Farahpour MR; Department of Clinical Sciences, Faculty of Veterinary Medicine, Urmia Branch, Islamic Azad University, Urmia, Iran. |
| المصدر: | International journal of biological macromolecules [Int J Biol Macromol] 2023 Dec 31; Vol. 253 (Pt 5), pp. 127081. Date of Electronic Publication: 2023 Sep 26. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Amsterdam : Elsevier Original Publication: Guildford, Eng., IPC Science and Technology Press. |
| مواضيع طبية MeSH: | Chitosan*/chemistry , Myrtus* , Nanoparticles*/chemistry, Mice ; Animals ; Gelatin/chemistry ; Silicon Dioxide/chemistry ; Bandages ; Anti-Bacterial Agents |
| مستخلص: | Wound healing and health care requirements have attracted more attention, and the need to develop new drug-containing dressings to accelerate wound healing is required. Carboxymethyl chitosan (CMCS)/gelatin-based films with mesoporous silica nanoparticles (MSNs) containing the Myrtus communis L. (Myrtle) aqueous extract were designed to answer this demand. Myrtle aqueous extract included total phenolic content and good free radical scavenging ability in vitro assay. The infrared spectroscopy characterized the functional groups of myrtle extract and biocomposite films. It was found that mesoporous silica nanoparticles increased the tensile strength of the flexible dressings, which is essential in therapeutic uses. MSNs influenced swelling ratio, oxygen, and water vapor permeability that indicates the CMCS/Gelatin/Myrtle/5 % MSNs wound dressing can absorb wound exudates and preserve skin moisture. Also, these biocompatible nanoparticles reduced the cytotoxicity of fibroblast cells due to the decelerated drug release. Correspondingly, silica nanoparticles affected the extract release rate and could accumulate and release the extract prolonged in CMCS/Gelatin/Myrtle/5 % MSNs models. Finally, histological analysis showed collagen growth and fibroblast migration in wounds treated with CMCS/Gelatin/Myrtle/5 % MSNs, causing proper wound contraction and accelerating wound healing in mice models. The results suggest that CMCS/Gelatin/Myrtle/5 % MSNs films have a beneficial application as wound dressings. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2023 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Carboxymethyl chitosan; Extract; Mesoporous silica nanoparticles; Myrtus communis L.; Wound dressing; Wound healing |
| المشرفين على المادة: | 9012-76-4 (Chitosan) 9000-70-8 (Gelatin) 7631-86-9 (Silicon Dioxide) 0 (Anti-Bacterial Agents) |
| تواريخ الأحداث: | Date Created: 20230928 Date Completed: 20231127 Latest Revision: 20231127 |
| رمز التحديث: | 20231127 |
| DOI: | 10.1016/j.ijbiomac.2023.127081 |
| PMID: | 37769781 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1879-0003 |
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| DOI: | 10.1016/j.ijbiomac.2023.127081 |