Impact of Aging and Cellular Senescence in the Pathophysiology of Preeclampsia.

التفاصيل البيبلوغرافية
العنوان:	Impact of Aging and Cellular Senescence in the Pathophysiology of Preeclampsia.
المؤلفون:	Suvakov S; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA., Kattah AG; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA., Gojkovic T; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA., Enninga EAL; Division of Research, Department of Obstetrics and Gynecology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA., Pruett J; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA., Jayachandran M; Division of Hematology, Mayo Clinic, Rochester, Minnesota, USA., Sousa C; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA., Santos J; Division of Research, Department of Obstetrics and Gynecology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA., Abou Hassan C; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA., Gonzales-Suarez M; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA., Garovic VD; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA.; Division of Research, Department of Obstetrics and Gynecology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
المصدر:	Comprehensive Physiology [Compr Physiol] 2023 Sep 28; Vol. 13 (4), pp. 5077-5114. Date of Electronic Publication: 2023 Sep 28.
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Country of Publication: United States NLM ID: 101574442 Publication Model: Electronic Cited Medium: Internet ISSN: 2040-4603 (Electronic) Linking ISSN: 20404603 NLM ISO Abbreviation: Compr Physiol Subsets: MEDLINE
مواضيع طبية MeSH:	Aging/physiology , Cellular Senescence/physiology , Pre-Eclampsia/epidemiology , Pre-Eclampsia/metabolism , Pre-Eclampsia*/physiopathology, Female ; Humans ; Pregnancy
مستخلص:	The incidence of hypertensive disorders of pregnancy is increasing, which may be due to several factors, including an increased age at pregnancy and more comorbid health conditions during reproductive years. Preeclampsia, the most severe hypertensive disorder of pregnancy, has been associated with an increased risk of future disease, including cardiovascular and kidney diseases. Cellular senescence, the process of cell cycle arrest in response to many physiologic and maladaptive stimuli, may play an important role in the pathogenesis of preeclampsia and provide a mechanistic link to future disease. In this article, we will discuss the pathophysiology of preeclampsia, the many mechanisms of cellular senescence, evidence for the involvement of senescence in the development of preeclampsia, as well as evidence that cellular senescence may link preeclampsia to the risk of future disease. Lastly, we will explore how a better understanding of the role of cellular senescence in preeclampsia may lead to therapeutic trials. © 2023 American Physiological Society. Compr Physiol 13:5077-5114, 2023. (Copyright © 2023 American Physiological Society. All rights reserved.)
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تواريخ الأحداث:	Date Created: 20230928 Date Completed: 20231004 Latest Revision: 20240807
رمز التحديث:	20240807
DOI:	10.1002/cphy.c230003
PMID:	37770190
قاعدة البيانات:	MEDLINE

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تدمد:	2040-4603
DOI:	10.1002/cphy.c230003