دورية أكاديمية
Anserine is expressed in human cardiac and skeletal muscles.
| العنوان: | Anserine is expressed in human cardiac and skeletal muscles. |
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| المؤلفون: | de Souza Gonçalves L; Applied Physiology & Nutrition Research Group-Center of Lifestyle, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.; Division of Pediatrics, Department of Pediatrics, University of California, San Francisco, California, USA., Pereira WR; Applied Physiology & Nutrition Research Group-Center of Lifestyle, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil., da Silva RP; Applied Physiology & Nutrition Research Group-Center of Lifestyle, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil., Yamaguchi GC; Applied Physiology & Nutrition Research Group-Center of Lifestyle, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil., Carvalho VH; Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, Brasil., Vargas BS; Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, Brasil., Jensen L; Laboratorio de Hipertensao do Instituto do Coraçao do Hospital das Clínicas da Faculdade de Medicina da Universidade São Paulo, São Paulo, Brazil., de Medeiros MHG; Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, Brasil., Roschel H; Applied Physiology & Nutrition Research Group-Center of Lifestyle, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil., Artioli GG; Department of Life Sciences, Manchester Metropolitan University, Manchester, UK. |
| المصدر: | Physiological reports [Physiol Rep] 2023 Oct; Vol. 11 (19), pp. e15833. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society Country of Publication: United States NLM ID: 101607800 Publication Model: Print Cited Medium: Internet ISSN: 2051-817X (Electronic) Linking ISSN: 2051817X NLM ISO Abbreviation: Physiol Rep Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Malden MA] : published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society, 2013- |
| مواضيع طبية MeSH: | Anserine*/analysis , Anserine*/metabolism , Carnosine*/analysis , Carnosine*/metabolism, Humans ; Muscle, Skeletal/metabolism ; Dipeptides/metabolism ; Myocardium/metabolism |
| مستخلص: | We evaluated whether anserine, a methylated analog of the dipeptide carnosine, is present in the cardiac and skeletal muscles of humans and whether the CARNMT1 gene, which encodes the anserine synthesizing enzyme carnosine-N-methyltransferase, is expressed in human skeletal muscle. We found that anserine is present at low concentrations (low micromolar range) in both cardiac and skeletal muscles, and that anserine content in skeletal muscle is ~15 times higher than in cardiac muscle (cardiac muscle: 10.1 ± 13.4 μmol·kg -1 of dry muscle, n = 12; skeletal muscle: 158.1 ± 68.5 μmol·kg -1 of dry muscle, n = 11, p < 0.0001). Anserine content in the heart was highly variable between individuals, ranging from 1.4 to 45.4 μmol·kg -1 of dry muscle, but anserine content was not associated with sex, age, or body mass. We also showed that CARNMT1 gene is poorly expressed in skeletal muscle (n = 10). This is the first study to demonstrate that anserine is present in the ventricle of the human heart. The presence of anserine in human heart and the confirmation of its expression in human skeletal muscle open new avenues of investigation on the specific and differential physiological functions of histidine dipeptides in striated muscles. (© 2023 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.) |
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| فهرسة مساهمة: | Keywords: anserine; carnosine-N-methyltransferase; heart; human; muscle |
| المشرفين على المادة: | HDQ4N37UGV (Anserine) 8HO6PVN24W (Carnosine) 0 (Dipeptides) |
| تواريخ الأحداث: | Date Created: 20230929 Date Completed: 20231002 Latest Revision: 20231016 |
| رمز التحديث: | 20231016 |
| مُعرف محوري في PubMed: | PMC10539627 |
| DOI: | 10.14814/phy2.15833 |
| PMID: | 37771070 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2051-817X |
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| DOI: | 10.14814/phy2.15833 |