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Mapping the spatial transcriptomic signature of the hippocampus during memory consolidation.

التفاصيل البيبلوغرافية
العنوان: Mapping the spatial transcriptomic signature of the hippocampus during memory consolidation.
المؤلفون: Vanrobaeys Y; Department of Neuroscience and Pharmacology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.; Iowa Neuroscience Institute, University of Iowa, Iowa City, IA, USA.; Interdisciplinary Graduate Program in Genetics, University of Iowa, Iowa City, IA, 52242, USA., Mukherjee U; Department of Neuroscience and Pharmacology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.; Iowa Neuroscience Institute, University of Iowa, Iowa City, IA, USA.; Interdisciplinary Graduate Program in Neuroscience, University of Iowa, Iowa City, IA, 52242, USA., Langmack L; Department of Neuroscience and Pharmacology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.; Iowa Neuroscience Institute, University of Iowa, Iowa City, IA, USA.; Biochemistry and Molecular Biology Graduate Program, University of Iowa, Iowa City, IA, USA., Beyer SE; Department of Neuroscience and Pharmacology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.; Iowa Neuroscience Institute, University of Iowa, Iowa City, IA, USA., Bahl E; Interdisciplinary Graduate Program in Genetics, University of Iowa, Iowa City, IA, 52242, USA.; Department of Psychiatry, University of Iowa, Iowa City, IA, USA., Lin LC; Department of Neuroscience and Pharmacology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.; Iowa Neuroscience Institute, University of Iowa, Iowa City, IA, USA., Michaelson JJ; Iowa Neuroscience Institute, University of Iowa, Iowa City, IA, USA.; Department of Psychiatry, University of Iowa, Iowa City, IA, USA., Abel T; Department of Neuroscience and Pharmacology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA. ted-abel@uiowa.edu.; Iowa Neuroscience Institute, University of Iowa, Iowa City, IA, USA. ted-abel@uiowa.edu., Chatterjee S; Department of Neuroscience and Pharmacology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA. snehajyoti-chatterjee@uiowa.edu.; Iowa Neuroscience Institute, University of Iowa, Iowa City, IA, USA. snehajyoti-chatterjee@uiowa.edu.
المصدر: Nature communications [Nat Commun] 2023 Sep 29; Vol. 14 (1), pp. 6100. Date of Electronic Publication: 2023 Sep 29.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : Nature Pub. Group
مواضيع طبية MeSH: Transcriptome*/genetics , Memory Consolidation*, Male ; Mice ; Animals ; Hippocampus/physiology ; CA1 Region, Hippocampal/metabolism ; Learning
مستخلص: Memory consolidation involves discrete patterns of transcriptional events in the hippocampus. Despite the emergence of single-cell transcriptomic profiling techniques, mapping the transcriptomic signature across subregions of the hippocampus has remained challenging. Here, we utilized unbiased spatial sequencing to delineate transcriptome-wide gene expression changes across subregions of the dorsal hippocampus of male mice following learning. We find that each subregion of the hippocampus exhibits distinct yet overlapping transcriptomic signatures. The CA1 region exhibited increased expression of genes related to transcriptional regulation, while the DG showed upregulation of genes associated with protein folding. Importantly, our approach enabled us to define the transcriptomic signature of learning within two less-defined hippocampal subregions, CA1 stratum radiatum, and oriens. We demonstrated that CA1 subregion-specific expression of a transcription factor subfamily has a critical functional role in the consolidation of long-term memory. This work demonstrates the power of spatial molecular approaches to reveal simultaneous transcriptional events across the hippocampus during memory consolidation.
(© 2023. Springer Nature Limited.)
التعليقات: Update of: bioRxiv. 2023 Jan 19;:. (PMID: 36711475)
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معلومات مُعتمدة: K99 AG068306 United States AG NIA NIH HHS; P50 HD103556 United States HD NICHD NIH HHS; R00 AG068306 United States AG NIA NIH HHS; R01 MH087463 United States MH NIMH NIH HHS
تواريخ الأحداث: Date Created: 20230929 Date Completed: 20231004 Latest Revision: 20240129
رمز التحديث: 20240129
مُعرف محوري في PubMed: PMC10541893
DOI: 10.1038/s41467-023-41715-7
PMID: 37773230
قاعدة البيانات: MEDLINE
الوصف
تدمد:2041-1723
DOI:10.1038/s41467-023-41715-7