دورية أكاديمية
Calreticulin Expression in Human Carcinomas: A Systematic Review and Meta-Analysis.
العنوان: | Calreticulin Expression in Human Carcinomas: A Systematic Review and Meta-Analysis. |
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المؤلفون: | Paravani Palacon M; Department of Diagnosis and Surgery, São Paulo State University (UNESP), School of Dentistry, Araraquara, São Paulo, Brazil., Morandin Ferrisse T; Department of Dental Prothesis, São Paulo State University (UNESP), School of Dentistry, Araraquara, São Paulo, Brazil., De Oliveira Barbeiro C; Department of Diagnosis and Surgery, São Paulo State University (UNESP), School of Dentistry, Araraquara, São Paulo, Brazil., Maria Sgavioli Massucato E; Department of Diagnosis and Surgery, São Paulo State University (UNESP), School of Dentistry, Araraquara, São Paulo, Brazil., Bufalino A; Department of Diagnosis and Surgery, São Paulo State University (UNESP), School of Dentistry, Araraquara, São Paulo, Brazil. |
المصدر: | Asian Pacific journal of cancer prevention : APJCP [Asian Pac J Cancer Prev] 2023 Sep 01; Vol. 24 (9), pp. 2929-2940. Date of Electronic Publication: 2023 Sep 01. |
نوع المنشور: | Meta-Analysis; Systematic Review; Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Asian Pacific Organization for Cancer Prevention Country of Publication: Thailand NLM ID: 101130625 Publication Model: Electronic Cited Medium: Internet ISSN: 2476-762X (Electronic) Linking ISSN: 15137368 NLM ISO Abbreviation: Asian Pac J Cancer Prev Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Bangkok : Asian Pacific Organization for Cancer Prevention, |
مواضيع طبية MeSH: | Calreticulin* , Carcinoma*/pathology, Humans ; Lymph Nodes/pathology ; Lymphatic Metastasis/pathology |
مستخلص: | Objective: The present study performed a systematic review and meta-analysis of observational studies on whether calreticulin levels could represent a prognostic factor in carcinoma patients. Calreticulin (CRT) is a multifunctional protein in the endoplasmic reticulum that can play distinct roles in different cancers. Methods: The search was performed in PubMed, Scopus, the Cochrane Library, Web of Science, Lilacs, Science Direct, Embase, Bireme, and SciELO databases. After a full-text evaluation, only 14 articles remained. The RoBANS tool assessed the risk of bias. The meta-analysis was performed with R software, and the odds ratio (OR) was the effect measure. The random effects model was chosen, and the quality of evidence was evaluated according to GRADE. Result: The most frequent carcinomas were in the breasts and the colon. CRT expression varied according to carcinoma origin and type, but these diseases had a prevalence of high CRT levels, indicating tumor progression. The high CRT levels were associated with lymph node metastasis (OR = 3.06 [1.71; 5.48]/p = 0.0002/I2 = 0%). All included articles had a blinding bias. Conclusion: High CRT levels may represent a prognostic factor for metastatic lymph nodes in carcinoma patients. |
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فهرسة مساهمة: | Keywords: Calreticulin; Carcinoma; Neoplasms; Prognosis; Systematic review |
المشرفين على المادة: | 0 (Calreticulin) 0 (CALR protein, human) |
تواريخ الأحداث: | Date Created: 20230929 Date Completed: 20231005 Latest Revision: 20240105 |
رمز التحديث: | 20240105 |
مُعرف محوري في PubMed: | PMC10762747 |
DOI: | 10.31557/APJCP.2023.24.9.2929 |
PMID: | 37774043 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2476-762X |
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DOI: | 10.31557/APJCP.2023.24.9.2929 |