دورية أكاديمية
Comparison of Anti-SARS-CoV-2-Specific Antibody Signatures in Maternal and Infant Blood after COVID-19 Infection versus COVID-19 Vaccination during Pregnancy.
| العنوان: | Comparison of Anti-SARS-CoV-2-Specific Antibody Signatures in Maternal and Infant Blood after COVID-19 Infection versus COVID-19 Vaccination during Pregnancy. |
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| المؤلفون: | Sabharwal V; Department of Pediatrics, Boston Medical Center, Boston, Massachusetts., Taglauer E; Department of Pediatrics, Boston Medical Center, Boston, Massachusetts., Demos R; Boston University School of Medicine, Boston, Massachusetts., Snyder-Cappione J; Department of Microbiology, Boston University School of Medicine, Boston, Massachusetts., Shaik-Dasthagirisaheb YB; Department of Pediatrics, Boston Medical Center, Boston, Massachusetts., Parker-Kelleher S; Boston University School of Public Health, Boston, Massachusetts., Hunnewell J; Boston University School of Public Health, Boston, Massachusetts., Boateng J; Department of Pediatrics, Boston Medical Center, Boston, Massachusetts., Clarke K; Department of Microbiology, Boston University School of Medicine, Boston, Massachusetts., Yuen R; Department of Microbiology, Boston University School of Medicine, Boston, Massachusetts., Barnett ED; Department of Pediatrics, Boston Medical Center, Boston, Massachusetts., Wachman EM; Department of Pediatrics, Boston Medical Center, Boston, Massachusetts., Yarrington CD; Department of Obstetrics and Gynecology, Boston Medical Center, Boston, Massachusetts. |
| المصدر: | American journal of perinatology [Am J Perinatol] 2024 May; Vol. 41 (S 01), pp. e2970-e2977. Date of Electronic Publication: 2023 Sep 29. |
| نوع المنشور: | Journal Article; Comparative Study; Research Support, N.I.H., Extramural |
| اللغة: | English |
| بيانات الدورية: | Publisher: Thieme-Stratton Country of Publication: United States NLM ID: 8405212 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-8785 (Electronic) Linking ISSN: 07351631 NLM ISO Abbreviation: Am J Perinatol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York, NY : Thieme-Stratton, 1983- |
| مواضيع طبية MeSH: | COVID-19*/prevention & control , COVID-19*/immunology , COVID-19 Vaccines*/immunology , COVID-19 Vaccines*/administration & dosage , Antibodies, Viral*/blood , SARS-CoV-2*/immunology , Pregnancy Complications, Infectious*/immunology , Pregnancy Complications, Infectious*/prevention & control , Pregnancy Complications, Infectious*/blood , Immunoglobulin G*/blood , Spike Glycoprotein, Coronavirus*/immunology, Humans ; Pregnancy ; Female ; Adult ; Infant, Newborn ; Immunoglobulin A/blood ; Fetal Blood/immunology ; Immunoglobulin M/blood ; Vaccination ; Coronavirus Nucleocapsid Proteins/immunology |
| مستخلص: | Objective: The Advisory Committee on Immunization Practices and The American College of Obstetricians and Gynecologists recommend coronavirus disease 2019 (COVID-19) vaccine for pregnant persons to prevent severe illness and death. The objective was to examine levels of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) IgG, IgM, and IgA against spike protein receptor binding domain (RBD) and nucleocapsid protein (NCP) in maternal and infant/cord blood at delivery after COVID 19 vaccination compared with SARS-CoV-2 infection at in mother-infant dyads at specified time points. Study Design: Mothers with SARS-CoV-2 infection ( n = 31) or COVID-19 vaccination ( n = 25) during pregnancy were enrolled between July 2020 and November 2021. Samples were collected at delivery and IgG, IgM, and IgA to RBD of spike and NCPs compared in the infected and vaccinated groups. Timing of infection/vaccination prior to delivery and correlation with antibody levels was performed. Results: The majority of participants received vaccination within 90 days of delivery and over half received the Pfizer BioNTech vaccine. There were no significant correlations between antibody levels and timing of infection or vaccination. Infant IgG levels to the RBD domain of spike protein were higher in the vaccinated group ( n = 25) as compared with the infants born to mothers with infection ( n = 31). Vaccination against COVID-19 during pregnancy was associated with detectable maternal and infant anti-RBD IgG levels at delivery irrespective of the timing of vaccination. Conclusion: Timing of vaccination had no correlation to the antibody levels suggesting that the timing of maternal vaccination in the cohort did not matter. There was no IgM detected in infants from vaccinated mothers. Infants from vaccinated mothers had robust IgG titers to RBD, which have a lasting protective effect in infants. Key Points: · COVID-19 vaccination during pregnancy had detectable antibody.. · No correlation between antibody levels and timing of vaccination.. · Infants from vaccinated mothers had robust IgG titers to RBD.. Competing Interests: None declared. (Thieme. All rights reserved.) |
| معلومات مُعتمدة: | 1UL1TR001430 Boston University Clinical and Translational Science Institute |
| المشرفين على المادة: | 0 (COVID-19 Vaccines) 0 (Antibodies, Viral) 0 (Immunoglobulin G) 0 (Spike Glycoprotein, Coronavirus) 0 (spike protein, SARS-CoV-2) 0 (Immunoglobulin A) 0 (Immunoglobulin M) 0 (Coronavirus Nucleocapsid Proteins) |
| تواريخ الأحداث: | Date Created: 20230929 Date Completed: 20240605 Latest Revision: 20240730 |
| رمز التحديث: | 20240731 |
| DOI: | 10.1055/a-2183-9109 |
| PMID: | 37774748 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1098-8785 |
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| DOI: | 10.1055/a-2183-9109 |