دورية أكاديمية
Giant variations in giant virus genome packaging.
| العنوان: | Giant variations in giant virus genome packaging. |
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| المؤلفون: | Talbert PB; Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA. Electronic address: ptalbert@fredhutch.org., Henikoff S; Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA., Armache KJ; Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY, 10016, USA. |
| المصدر: | Trends in biochemical sciences [Trends Biochem Sci] 2023 Dec; Vol. 48 (12), pp. 1071-1082. Date of Electronic Publication: 2023 Sep 28. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Trends Journals Country of Publication: England NLM ID: 7610674 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 0968-0004 (Print) Linking ISSN: 09680004 NLM ISO Abbreviation: Trends Biochem Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Cambridge (Eng) : Elsevier Trends Journals Original Publication: Amsterdam, Published for the International Union of Biochemistry by Elsevier Scientific Pub. Co. |
| مواضيع طبية MeSH: | Viral Genome Packaging* , Nucleosomes*, Capsid Proteins/chemistry ; Capsid Proteins/genetics ; DNA ; Adenosine Triphosphatases/genetics ; Genome, Viral ; Virus Assembly/genetics |
| مستخلص: | Giant viruses (Nucleocytoviricota) have a largely conserved lifecycle, yet how they cram their large genomes into viral capsids is mostly unknown. The major capsid protein and the packaging ATPase (pATPase) comprise a highly conserved morphogenesis module in giant viruses, yet some giant viruses dispense with an icosahedral capsid, and others encode multiple versions of pATPases, including conjoined ATPase doublets, or encode none. Some giant viruses have acquired DNA-condensing proteins to compact their genomes, including sheath-like structures encasing folded DNA or densely packed viral nucleosomes that show a resemblance to eukaryotic nucleosomes at the telomeres. Here, we review what is known and unknown about these ATPases and condensing proteins, and place these variations in the context of viral lifecycles. (Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.) |
| فهرسة مساهمة: | Keywords: ATPase; capsid; histone; nucleosome; oxidoreductase; telomere |
| المشرفين على المادة: | 0 (Nucleosomes) 0 (Capsid Proteins) 9007-49-2 (DNA) EC 3.6.1.- (Adenosine Triphosphatases) |
| تواريخ الأحداث: | Date Created: 20230930 Date Completed: 20231113 Latest Revision: 20240312 |
| رمز التحديث: | 20240312 |
| DOI: | 10.1016/j.tibs.2023.09.003 |
| PMID: | 37777391 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0968-0004 |
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| DOI: | 10.1016/j.tibs.2023.09.003 |