دورية أكاديمية
The emerging role of receptor tyrosine kinase phase separation in cancer.
| العنوان: | The emerging role of receptor tyrosine kinase phase separation in cancer. |
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| المؤلفون: | Lin CC; School of Molecular and Cellular Biology, University of Leeds, Leeds, LS2 9JT, UK. Electronic address: c.c.lin@leeds.ac.uk., Suen KM; School of Molecular and Cellular Biology, University of Leeds, Leeds, LS2 9JT, UK., Lidster J; School of Molecular and Cellular Biology, University of Leeds, Leeds, LS2 9JT, UK., Ladbury JE; School of Molecular and Cellular Biology, University of Leeds, Leeds, LS2 9JT, UK. Electronic address: j.e.ladbury@leeds.ac.uk. |
| المصدر: | Trends in cell biology [Trends Cell Biol] 2024 May; Vol. 34 (5), pp. 371-379. Date of Electronic Publication: 2023 Sep 28. |
| نوع المنشور: | Journal Article; Review; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Publishers Country of Publication: England NLM ID: 9200566 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3088 (Electronic) Linking ISSN: 09628924 NLM ISO Abbreviation: Trends Cell Biol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Cambridge, UK : Elsevier Science Publishers, c1991- |
| مواضيع طبية MeSH: | Neoplasms*/metabolism , Neoplasms*/pathology , Receptor Protein-Tyrosine Kinases*/metabolism , Signal Transduction*, Humans ; Animals ; Phase Separation |
| مستخلص: | Receptor tyrosine kinase (RTK)-mediated signal transduction is fundamental to cell function and drives important cellular outcomes which, when dysregulated, can lead to malignant tumour growth and metastasis. The initiation of signals from plasma membrane-bound RTKs is subjected to multiple regulatory mechanisms that control downstream effector protein recruitment and function. The high propensity of RTKs to condense via liquid-liquid phase separation (LLPS) into membraneless organelles with downstream effector proteins provides a further fundamental mechanism for signal regulation. Herein we highlight how this phenomenon contributes to cancer signalling and consider the potential impact of LLPS on outcomes for cancer patients. Competing Interests: Declaration of interests The authors have no competing interests to declare. (Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.) |
| فهرسة مساهمة: | Keywords: cancer signalling; kinase signalling; liquid–liquid phase separation; protein condensate |
| المشرفين على المادة: | EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases) |
| تواريخ الأحداث: | Date Created: 20230930 Date Completed: 20240503 Latest Revision: 20240801 |
| رمز التحديث: | 20240802 |
| DOI: | 10.1016/j.tcb.2023.09.002 |
| PMID: | 37777392 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1879-3088 |
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| DOI: | 10.1016/j.tcb.2023.09.002 |