دورية أكاديمية
أعرض في EDS

The characterization of RNA-binding proteins and RNA metabolism-related proteins in fungal extracellular vesicles.

التفاصيل البيبلوغرافية
العنوان: The characterization of RNA-binding proteins and RNA metabolism-related proteins in fungal extracellular vesicles.
المؤلفون: Dallastella M; Gene Expression Regulation Laboratory, Carlos Chagas Institute (ICC), Oswaldo Cruz Foundation, FIOCRUZ, Curitiba, Brazil., de Oliveira WK; Laboratory for Applied Sciences and Technology in Health, Carlos Chagas Institute, FIOCRUZ PR, Curitiba, Brazil., Rodrigues ML; Gene Expression Regulation Laboratory, Carlos Chagas Institute (ICC), Oswaldo Cruz Foundation, FIOCRUZ, Curitiba, Brazil.; Microbiology Institute, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil., Goldenberg S; Gene Expression Regulation Laboratory, Carlos Chagas Institute (ICC), Oswaldo Cruz Foundation, FIOCRUZ, Curitiba, Brazil., Alves LR; Gene Expression Regulation Laboratory, Carlos Chagas Institute (ICC), Oswaldo Cruz Foundation, FIOCRUZ, Curitiba, Brazil.; Research Center in Infectious Diseases, Division of Infectious Disease and Immunity CHU de Quebec Research Center, University Laval, Quebec, QC, Canada.
المصدر: Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2023 Sep 14; Vol. 13, pp. 1247329. Date of Electronic Publication: 2023 Sep 14 (Print Publication: 2023).
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Frontiers Media SA Country of Publication: Switzerland NLM ID: 101585359 Publication Model: eCollection Cited Medium: Internet ISSN: 2235-2988 (Electronic) Linking ISSN: 22352988 NLM ISO Abbreviation: Front Cell Infect Microbiol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Lausanne : Frontiers Media SA
مواضيع طبية MeSH: RNA*/analysis , Extracellular Vesicles*/metabolism, Animals ; Proteomics ; RNA, Messenger/metabolism ; RNA-Binding Proteins/metabolism ; Mammals/genetics
مستخلص: RNA-binding proteins (RBPs) are essential for regulating RNA metabolism, stability, and translation within cells. Recent studies have shown that RBPs are not restricted to intracellular functions and can be found in extracellular vesicles (EVs) in different mammalian cells. EVs released by fungi contain a variety of proteins involved in RNA metabolism. These include RNA helicases, which play essential roles in RNA synthesis, folding, and degradation. Aminoacyl-tRNA synthetases, responsible for acetylating tRNA molecules, are also enriched in EVs, suggesting a possible link between these enzymes and tRNA fragments detected in EVs. Proteins with canonical RNA-binding domains interact with proteins and RNA, such as the RNA Recognition Motif (RRM), Zinc finger, and hnRNP K-homology (KH) domains. Polyadenylate-binding protein (PABP) plays a critical role in the regulation of gene expression by binding the poly(A) tail of messenger RNA (mRNA) and facilitating its translation, stability, and localization, making it a key factor in post-transcriptional control of gene expression. The presence of proteins related to the RNA life cycle in EVs from different fungal species suggests a conserved mechanism of EV cargo packing. Various models have been proposed for selecting RNA molecules for release into EVs. Still, the actual loading processes are unknown, and further molecular characterization of these proteins may provide insight into the mechanism of RNA sorting into EVs. This work reviews the current knowledge of RBPs and proteins related to RNA metabolism in EVs derived from distinct fungi species, and presents an analysis of proteomic datasets through GO term and orthology analysis, Our investigation identified orthologous proteins in fungal EVs on different fungal species.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2023 Dallastella, Oliveira, Rodrigues, Goldenberg and Alves.)
References: Sci Rep. 2018 Jul 17;8(1):10813. (PMID: 30018314)
Nat Rev Mol Cell Biol. 2018 Apr;19(4):213-228. (PMID: 29339798)
Clin Microbiol Rev. 2011 Oct;24(4):633-54. (PMID: 21976602)
Semin Cancer Biol. 2014 Oct;28:3-13. (PMID: 24769058)
Nat Rev Mol Cell Biol. 2019 Sep;20(9):509-510. (PMID: 31324871)
Eukaryot Cell. 2007 Jan;6(1):48-59. (PMID: 17114598)
Bioinformatics. 2006 Jul 1;22(13):1658-9. (PMID: 16731699)
Comput Struct Biotechnol J. 2021 Apr 17;19:2286-2296. (PMID: 33995920)
Cell Rep. 2016 Oct 11;17(3):799-808. (PMID: 27732855)
J Biol Chem. 2013 Oct 11;288(41):29223-8. (PMID: 24003230)
Elife. 2021 Nov 12;10:. (PMID: 34766549)
Nucleic Acids Res. 2019 Jan 8;47(D1):D516-D519. (PMID: 30395310)
Cell Microbiol. 2008 Aug;10(8):1695-710. (PMID: 18419773)
J Clin Invest. 2005 Oct;115(10):2875-85. (PMID: 16151533)
Infect Dis Clin North Am. 2002 Dec;16(4):837-74, v-vi. (PMID: 12512184)
Acta Physiol (Oxf). 2018 Feb;222(2):. (PMID: 29253314)
J Cell Sci. 2020 Sep 1;133(16):. (PMID: 32873715)
Trends Biochem Sci. 2018 Apr;43(4):237-250. (PMID: 29486979)
Elife. 2019 Aug 27;8:. (PMID: 31453808)
Nat Plants. 2021 Mar;7(3):342-352. (PMID: 33633358)
Front Microbiol. 2018 Oct 02;9:2286. (PMID: 30333803)
J Extracell Vesicles. 2013 Dec 11;2:. (PMID: 24363837)
Sci Rep. 2015 Jan 14;5:7763. (PMID: 25586039)
RNA Biol. 2014;11(8):1019-30. (PMID: 25531407)
PLoS One. 2010 Jun 14;5(6):e11113. (PMID: 20559436)
Proteomics. 2019 Apr;19(8):e1800232. (PMID: 30883019)
Wiley Interdiscip Rev RNA. 2014 Jul-Aug;5(4):461-80. (PMID: 24706556)
mSphere. 2020 Aug 12;5(4):. (PMID: 32817450)
Asian Pac J Cancer Prev. 2022 Jun 01;23(6):1893-1900. (PMID: 35763629)
Fungal Biol Biotechnol. 2020 Sep 18;7:13. (PMID: 32968488)
Clin Microbiol Rev. 2007 Jan;20(1):133-63. (PMID: 17223626)
Med Sci Monit. 2020 Jun 05;26:e923210. (PMID: 32502142)
Fungal Genet Biol. 2020 Nov;144:103447. (PMID: 32827756)
Biochem Soc Trans. 2017 Dec 15;45(6):1313-1321. (PMID: 29150525)
Sci Rep. 2017 Jan 04;7:39742. (PMID: 28051166)
Cells. 2020 Apr 22;9(4):. (PMID: 32331346)
Cell Mol Life Sci. 2017 Aug;74(16):2875-2897. (PMID: 28314893)
Nat Commun. 2023 Jul 20;14(1):4383. (PMID: 37474601)
J Extracell Vesicles. 2021 Aug;10(10):e12129. (PMID: 34377375)
J Proteomics. 2014 Jan 31;97:177-86. (PMID: 23583696)
Cell. 2016 Mar 10;164(6):1226-1232. (PMID: 26967288)
PLoS Biol. 2012;10(12):e1001450. (PMID: 23271954)
J Fungi (Basel). 2021 Jul 14;7(7):. (PMID: 34356940)
Front Immunol. 2019 Feb 28;10:202. (PMID: 30873152)
Nat Rev Genet. 2014 Dec;15(12):829-45. (PMID: 25365966)
Nat Commun. 2013;4:2980. (PMID: 24356509)
Int J Mol Sci. 2021 Sep 06;22(17):. (PMID: 34502537)
J Extracell Vesicles. 2020 Dec;10(2):e12043. (PMID: 33391635)
Front Cell Infect Microbiol. 2020 Nov 18;10:593160. (PMID: 33312966)
Eukaryot Cell. 2014 Dec;13(12):1484-93. (PMID: 24906412)
PLoS One. 2018 Apr 24;13(4):e0195969. (PMID: 29689087)
Autophagy. 2023 May;19(5):1551-1561. (PMID: 36286616)
mSphere. 2019 Mar 27;4(2):. (PMID: 30918062)
Cells. 2021 Oct 06;10(10):. (PMID: 34685656)
J Mol Med (Berl). 2022 May;100(5):679-695. (PMID: 35322869)
Future Microbiol. 2011 Nov;6(11):1371-81. (PMID: 22082294)
Eukaryot Cell. 2008 Jan;7(1):58-67. (PMID: 18039940)
Nat Cell Biol. 2007 Jun;9(6):654-9. (PMID: 17486113)
N Engl J Med. 2015 Oct 8;373(15):1445-56. (PMID: 26444731)
Annu Rev Biochem. 2015;84:291-323. (PMID: 25784052)
Biomolecules. 2023 May 18;13(5):. (PMID: 37238722)
Cell Microbiol. 2015 Mar;17(3):389-407. (PMID: 25287304)
Cold Spring Harb Perspect Biol. 2011 Jul 01;3(7):. (PMID: 21441581)
Front Microbiol. 2022 Feb 18;13:817844. (PMID: 35250933)
J Extracell Vesicles. 2015 May 14;4:27066. (PMID: 25979354)
J Proteome Res. 2012 Mar 2;11(3):1676-85. (PMID: 22288420)
Mycopathologia. 2020 Oct;185(5):813-842. (PMID: 32052359)
Cold Spring Harb Perspect Biol. 2012 Sep 01;4(9):a012286. (PMID: 22763747)
mSphere. 2016 Mar 30;1(2):. (PMID: 27303729)
Nat Rev Mol Cell Biol. 2011 Jul 22;12(8):505-16. (PMID: 21779027)
Cell Rep. 2016 May 3;15(5):978-987. (PMID: 27117408)
J Cell Biol. 2017 Jul 3;216(7):2201-2216. (PMID: 28611052)
Medicine (Baltimore). 2000 Jul;79(4):250-60. (PMID: 10941354)
Front Cell Infect Microbiol. 2019 Apr 11;9:100. (PMID: 31032233)
Nucleic Acids Res. 1997 Sep 1;25(17):3389-402. (PMID: 9254694)
Nat Commun. 2017 Feb 17;8:14448. (PMID: 28211508)
PLoS Biol. 2018 Oct 8;16(10):e2006872. (PMID: 30296253)
Elife. 2019 Aug 22;8:. (PMID: 31436530)
Methods Mol Biol. 2016;1459:175-90. (PMID: 27665559)
Methods Mol Biol. 2014;1097:491-521. (PMID: 24639174)
J Extracell Vesicles. 2020 Nov;10(1):e12029. (PMID: 33708357)
Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):E8987-E8995. (PMID: 29073095)
J Proteome Res. 2015 Jan 2;14(1):142-53. (PMID: 25367658)
Biochim Biophys Acta Proteins Proteom. 2019 Dec;1867(12):140203. (PMID: 30822540)
Genes Dev. 2016 Mar 1;30(5):553-66. (PMID: 26944680)
Front Plant Sci. 2020 Jan 10;10:1610. (PMID: 31998330)
J Mol Biol. 1990 Oct 5;215(3):403-10. (PMID: 2231712)
فهرسة مساهمة: Keywords: RNA metabolism; RNA-Binding Proteins; cellular communication; extracellular vesicles; proteomic data
المشرفين على المادة: 63231-63-0 (RNA)
0 (RNA, Messenger)
0 (RNA-Binding Proteins)
تواريخ الأحداث: Date Created: 20231002 Date Completed: 20231003 Latest Revision: 20231003
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10539620
DOI: 10.3389/fcimb.2023.1247329
PMID: 37780856
قاعدة البيانات: MEDLINE
الوصف
تدمد:2235-2988
DOI:10.3389/fcimb.2023.1247329