دورية أكاديمية
The characterization of RNA-binding proteins and RNA metabolism-related proteins in fungal extracellular vesicles.
العنوان: | The characterization of RNA-binding proteins and RNA metabolism-related proteins in fungal extracellular vesicles. |
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المؤلفون: | Dallastella M; Gene Expression Regulation Laboratory, Carlos Chagas Institute (ICC), Oswaldo Cruz Foundation, FIOCRUZ, Curitiba, Brazil., de Oliveira WK; Laboratory for Applied Sciences and Technology in Health, Carlos Chagas Institute, FIOCRUZ PR, Curitiba, Brazil., Rodrigues ML; Gene Expression Regulation Laboratory, Carlos Chagas Institute (ICC), Oswaldo Cruz Foundation, FIOCRUZ, Curitiba, Brazil.; Microbiology Institute, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil., Goldenberg S; Gene Expression Regulation Laboratory, Carlos Chagas Institute (ICC), Oswaldo Cruz Foundation, FIOCRUZ, Curitiba, Brazil., Alves LR; Gene Expression Regulation Laboratory, Carlos Chagas Institute (ICC), Oswaldo Cruz Foundation, FIOCRUZ, Curitiba, Brazil.; Research Center in Infectious Diseases, Division of Infectious Disease and Immunity CHU de Quebec Research Center, University Laval, Quebec, QC, Canada. |
المصدر: | Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2023 Sep 14; Vol. 13, pp. 1247329. Date of Electronic Publication: 2023 Sep 14 (Print Publication: 2023). |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Frontiers Media SA Country of Publication: Switzerland NLM ID: 101585359 Publication Model: eCollection Cited Medium: Internet ISSN: 2235-2988 (Electronic) Linking ISSN: 22352988 NLM ISO Abbreviation: Front Cell Infect Microbiol Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Lausanne : Frontiers Media SA |
مواضيع طبية MeSH: | RNA*/analysis , Extracellular Vesicles*/metabolism, Animals ; Proteomics ; RNA, Messenger/metabolism ; RNA-Binding Proteins/metabolism ; Mammals/genetics |
مستخلص: | RNA-binding proteins (RBPs) are essential for regulating RNA metabolism, stability, and translation within cells. Recent studies have shown that RBPs are not restricted to intracellular functions and can be found in extracellular vesicles (EVs) in different mammalian cells. EVs released by fungi contain a variety of proteins involved in RNA metabolism. These include RNA helicases, which play essential roles in RNA synthesis, folding, and degradation. Aminoacyl-tRNA synthetases, responsible for acetylating tRNA molecules, are also enriched in EVs, suggesting a possible link between these enzymes and tRNA fragments detected in EVs. Proteins with canonical RNA-binding domains interact with proteins and RNA, such as the RNA Recognition Motif (RRM), Zinc finger, and hnRNP K-homology (KH) domains. Polyadenylate-binding protein (PABP) plays a critical role in the regulation of gene expression by binding the poly(A) tail of messenger RNA (mRNA) and facilitating its translation, stability, and localization, making it a key factor in post-transcriptional control of gene expression. The presence of proteins related to the RNA life cycle in EVs from different fungal species suggests a conserved mechanism of EV cargo packing. Various models have been proposed for selecting RNA molecules for release into EVs. Still, the actual loading processes are unknown, and further molecular characterization of these proteins may provide insight into the mechanism of RNA sorting into EVs. This work reviews the current knowledge of RBPs and proteins related to RNA metabolism in EVs derived from distinct fungi species, and presents an analysis of proteomic datasets through GO term and orthology analysis, Our investigation identified orthologous proteins in fungal EVs on different fungal species. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Dallastella, Oliveira, Rodrigues, Goldenberg and Alves.) |
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فهرسة مساهمة: | Keywords: RNA metabolism; RNA-Binding Proteins; cellular communication; extracellular vesicles; proteomic data |
المشرفين على المادة: | 63231-63-0 (RNA) 0 (RNA, Messenger) 0 (RNA-Binding Proteins) |
تواريخ الأحداث: | Date Created: 20231002 Date Completed: 20231003 Latest Revision: 20231003 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC10539620 |
DOI: | 10.3389/fcimb.2023.1247329 |
PMID: | 37780856 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2235-2988 |
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DOI: | 10.3389/fcimb.2023.1247329 |