دورية أكاديمية
أعرض في EDS

Elevated liver transaminases among patients with psychiatric disorders.

التفاصيل البيبلوغرافية
العنوان: Elevated liver transaminases among patients with psychiatric disorders.
المؤلفون: Ali E; Psychiatry Department, Faculty of Medicine, Zagazig University., Abdel Maksoud MA; Tropical Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt., Arafa SM; Psychiatry Department, Faculty of Medicine, AlAzhar University for Girls, Cairo., Ibrahim D; Psychiatry Department, Faculty of Medicine, AlAzhar University for Girls, Cairo., Hassan AE; Medical Physiology Department, Faculty of Medicine, Zagazig University.; Basic Medical Sciences Department, Faculty of Medicine, Sulaiman Al Rajhi University, Al-Bukayriyah, Saudi Arabia., Awwad O; Family Medicine and Health Informatics Specialist at Ministry of Health and Population, Zagazig., Elbeltagy AM; Clinical Pathology Department, Faculty of Medicine, Mansoura University., Elmahdi E; Internal Medicine Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.; Internal Medicine Department, Faculty of Medicine, Shaqra University, Dawadmi, Saudi Arabia., Elgarhi R; Clinical Pharmacology Department, Faculty of Medicine, Zagazig University., Embaby A; Internal Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
المصدر: International clinical psychopharmacology [Int Clin Psychopharmacol] 2024 May 01; Vol. 39 (3), pp. 195-200. Date of Electronic Publication: 2024 Mar 25.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Lippincott Williams And Wilkins Country of Publication: England NLM ID: 8609061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-5857 (Electronic) Linking ISSN: 02681315 NLM ISO Abbreviation: Int Clin Psychopharmacol Subsets: MEDLINE
أسماء مطبوعة: Publication: London : Lippincott Williams And Wilkins
Original Publication: London : Clinical Neuroscience Publishers, c1986-
مواضيع طبية MeSH: Liver* , Mental Disorders*/drug therapy , Mental Disorders*/epidemiology, Adult ; Male ; Female ; Humans ; Cross-Sectional Studies ; Alanine Transaminase/therapeutic use ; Aspartate Aminotransferases/therapeutic use
مستخلص: Hepatocyte injury is assessed by serum aspartate transaminase and alanine transaminase estimation. In psychiatric populations, antipsychotic drugs (AD) are culprit in hepatic dysfunction. To assess transaminitis among psychiatric patients treated by AD. This cross-sectional study was conducted in Zagazig University Hospitals in Egypt, from December 2022 to February 2023. A total of 135 adult patients aged ≥ 18 years, were diagnosed with psychiatric disorders after exclusion of patients receiving any hepatotoxic drugs, viral hepatitis, having chronic liver or kidney diseases, diabetes mellitus, mental retardation, and pregnant females. Among the 135 patients, 104 (77.0%) were males. Their age was 32 ± 9, The most popular used class of AD was atypical AD 84 (62.2%). The overall incidence of transaminitis among patients receiving AD was 23/135 (17.04%) of patients; 13 (56.5%) were on atypical AD compared to 10 (43.5%) patients receiving combined AD, without any statistically significant difference. The use of AD in patients with psychiatric disorders is potentially safe with minimal transaminitis ( (Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.)
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المشرفين على المادة: EC 2.6.1.2 (Alanine Transaminase)
EC 2.6.1.1 (Aspartate Aminotransferases)
تواريخ الأحداث: Date Created: 20231002 Date Completed: 20240327 Latest Revision: 20240327
رمز التحديث: 20240327
DOI: 10.1097/YIC.0000000000000514
PMID: 37781786
قاعدة البيانات: MEDLINE
الوصف
تدمد:1473-5857
DOI:10.1097/YIC.0000000000000514