دورية أكاديمية
An in-vitro evaluation of antifungal, anti-lungcancer (A549), and anti-hyperglycemic activities potential of Andrographis paniculata (Burm. f.) flower extract.
| العنوان: | An in-vitro evaluation of antifungal, anti-lungcancer (A549), and anti-hyperglycemic activities potential of Andrographis paniculata (Burm. f.) flower extract. |
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| المؤلفون: | Phuong TN; Faculty of Medicine, Van Lang University, Ho Chi Minh City, Vietnam. Electronic address: phuong.tn@vlu.edu.vn., Duy Tai N; Faculty of Nursing and Medical Laboratory, HUTECH University, Vietnam., Aloufi AS; Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh, 11671, Saudi Arabia., Subramani B; Division of Hematology and Oncology, Department of Medicine, Mays Cancer Center, The University of Texas Health Science Center at San Antonio, TX, USA., Theivaraj SD; Department of Environmental Biotechnology, Bharathidasan University, Tiruchirappalli, 620 024, Tamil Nadu, India. Electronic address: sridevibdu.ebt@gmail.com. |
| المصدر: | Environmental research [Environ Res] 2023 Dec 01; Vol. 238 (Pt 2), pp. 117249. Date of Electronic Publication: 2023 Oct 01. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0147621 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0953 (Electronic) Linking ISSN: 00139351 NLM ISO Abbreviation: Environ Res Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2000- > : Amsterdam : Elsevier Original Publication: New York, Academic Press. |
| مواضيع طبية MeSH: | Antifungal Agents*/chemistry , Antifungal Agents*/pharmacology , Andrographis*/chemistry, Humans ; Andrographis paniculata ; Pandemics ; Flowers ; Water ; Hypoglycemic Agents/pharmacology |
| مستخلص: | The medical plant research has received more attention among researchers especially after the Covid-19 pandemic. This research performed to evaluate the antifungal, anti-lung cancer (A549), and anti-hyperglycemic activities of aqueous extract of Andrographis paniculata flower. Interestingly, A. paniculata flower aqueous extract contains pharmaceutically valuable phytochemicals such as alkaloid, phenolics, terpenoids, tannins, flavonoids, and protein. It also showed fine antifungal activity against test fungal pathogens in the following order as: Aspergillus niger > Fusarium solani > Trichoderma harzianum > A. parasiticus > P. expansum > Penicillium janthinellum with lowest MIC values as ranged from 100 to 300 μg mL -1 . Interestingly, this aqueous extract also showed considerable anti-lung cancer activity, evidenced by dose and time dependent lung cancer cell line (A549) growth/proliferation inhibition/cytotoxicity activity (65%) at 300 μg mL -1 concentration. This can be achieved by plant extract through inducing the secretion of apoptosis related proteins such as TNF α, IFN-γ, and ınterleukin 2 leads to apoptosis in A549 cells. It also showed fine anti-diabetic activity by inhibiting α -amylase (58.41%) than α-glucosidase (54.74%) at 200 μg mL -1 concentration. The UV as well as FTIR results demonstrated that the aqueous extract of A. paniculata flower contains pharmaceutically valuable bioactive compounds, which may be responsible for the wide range of biomedical applications. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2023 Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Andrographis paniculata flower; Antifungal activity; Cytotoxicity; FTIR; α -amylase and α-glucosidase activity |
| المشرفين على المادة: | 0 (Antifungal Agents) 059QF0KO0R (Water) 0 (Hypoglycemic Agents) |
| تواريخ الأحداث: | Date Created: 20231002 Date Completed: 20231108 Latest Revision: 20231108 |
| رمز التحديث: | 20231108 |
| DOI: | 10.1016/j.envres.2023.117249 |
| PMID: | 37783331 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1096-0953 |
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| DOI: | 10.1016/j.envres.2023.117249 |