دورية أكاديمية
أعرض في EDS

Antimicrobial resistance pattern of Klebsiella isolated from various clinical samples in Ethiopia: a systematic review and meta-analysis.

التفاصيل البيبلوغرافية
العنوان: Antimicrobial resistance pattern of Klebsiella isolated from various clinical samples in Ethiopia: a systematic review and meta-analysis.
المؤلفون: Gebremeskel L; Department of Pharmacology and Toxicology, School of Pharmacy, College of Health Sciences, Mekelle University, Mekelle, Ethiopia. lemeskel2005@gmail.com., Teklu T; Department of Pharmacy, College of health sciences, Aksum University, Aksum, Ethiopia., Kasahun GG; Department of Pharmacy, College of health sciences, Aksum University, Aksum, Ethiopia., Tuem KB; Department of Pharmacology and Toxicology, School of Pharmacy, College of Health Sciences, Mekelle University, Mekelle, Ethiopia.
المصدر: BMC infectious diseases [BMC Infect Dis] 2023 Oct 02; Vol. 23 (1), pp. 643. Date of Electronic Publication: 2023 Oct 02.
نوع المنشور: Meta-Analysis; Systematic Review; Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 100968551 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2334 (Electronic) Linking ISSN: 14712334 NLM ISO Abbreviation: BMC Infect Dis Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2001-
مواضيع طبية MeSH: Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/therapeutic use , Amikacin*, Humans ; Ethiopia/epidemiology ; Drug Resistance, Bacterial ; Ampicillin ; Amoxicillin ; Prevalence
مستخلص: Background: The burden of Klebsiella drug resistance to antimicrobials is a major public health concern worldwide; particularly the problem is severe in developing countries including Ethiopia. Therefore, the aim of this systematic review and meta-analysis is to establish the pooled estimate of Klebsiella drug resistance; and antimicrobial-specific resistance pattern among Klebsiella clinical isoaltes in Ethiopia.
Methods: Articles were searched from PubMed, Google Scholar, and Science direct and grey literature from 2009 to 2019. Four authors have independently extracted data on the prevalence and antimicrobial resistance pattern of the isolates. Statistical analysis was conducted by using Open meta-analyst (version 3.13) and Comprehensive meta-analysis (version 3.3). The main outcome measures were the overall Klebsiella resistance; and drug-specific resistance patterns. A random-effects model was used to determine the pooled resistance prevalence with 95% confidence interval (CI), and significant heterogeneity was considered at p < 0.1; and I 2  > 50% using DerSimonian and Laird method. In addition, subgroup analyses were conducted to improve the outcome.
Result: We obtained 174 potentially relevant studies through searching electronic databases, and finally, 35 eligible studies were included for meta-analysis. A total of 13,269 study samples participated, from which 1017 Klebsiella species were isolated. The overall Klebsiella resistance in Ethiopia was found to stand at 53.75% (95% CI: 48.35-58.94%). Based on the subgroup analyses; the highest (64.39%); and lowest (46.16%) values were seen in Southern Nations, Nationalities, and Peoples of Ethiopia; and Tigray regions respectively; and the highest Klebsiella resistance was reported to ampicillin (90.56%), followed by amoxicillin (76.01%) and trimethoprim-sulfamethoxazole (66.91%). A relatively low level of resistance rate was observed to amikacin (16.74%) and cefoxitin (29.73%).
Conclusion: The pooled Klebsiella resistance was found to be considerably high (53.75%) to most of the essential antibiotics in Ethiopia. Klebsiella was highly resistant to ampicillin and amoxicillin but relatively lower to amikacin. Therefore, appropriate interventional strategies need to be taken to address the emerging resistance of Klebsiella species.
(© 2023. BioMed Central Ltd., part of Springer Nature.)
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فهرسة مساهمة: Keywords: Antimicrobial resistance; Ethiopia; Klebsiella resistance; Meta-analysis; Systematic review
المشرفين على المادة: 0 (Anti-Bacterial Agents)
84319SGC3C (Amikacin)
7C782967RD (Ampicillin)
804826J2HU (Amoxicillin)
تواريخ الأحداث: Date Created: 20231002 Date Completed: 20231004 Latest Revision: 20231120
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10544621
DOI: 10.1186/s12879-023-08633-x
PMID: 37784058
قاعدة البيانات: MEDLINE
الوصف
تدمد:1471-2334
DOI:10.1186/s12879-023-08633-x