Identification of Mid-Polar and Polar AhR Agonists in Cetaceans from Korean Coastal Waters: Application of Effect-Directed Analysis with Full-Scan Screening.

التفاصيل البيبلوغرافية
العنوان:	Identification of Mid-Polar and Polar AhR Agonists in Cetaceans from Korean Coastal Waters: Application of Effect-Directed Analysis with Full-Scan Screening.
المؤلفون:	Cha J; Department of Marine Environmental Science, Chungnam National University, Daejeon 34134, Republic of Korea., Hong S; Department of Marine Environmental Science, Chungnam National University, Daejeon 34134, Republic of Korea., Lee J; School of Earth and Environmental Sciences & Research Institute of Oceanography, Seoul National University, Seoul 08826, Republic of Korea.; Department of Environmental Education, Kongju National University, Gongju 32588, Republic of Korea., Gwak J; Department of Marine Environmental Science, Chungnam National University, Daejeon 34134, Republic of Korea., Kim M; Department of Marine Environmental Science, Chungnam National University, Daejeon 34134, Republic of Korea., Mok S; Department of Marine Science and Convergence Engineering, Hanyang University, Ansan 15588, Republic of Korea., Moon HB; Department of Marine Science and Convergence Engineering, Hanyang University, Ansan 15588, Republic of Korea., Jones PD; Department of Veterinary Biomedical Sciences & Toxicology Centre, University of Saskatchewan, Saskatoon, Saskatchewan S7N5B3, Canada., Giesy JP; Department of Veterinary Biomedical Sciences & Toxicology Centre, University of Saskatchewan, Saskatoon, Saskatchewan S7N5B3, Canada.; Department of Integrative Biology and Institute for Integrative Toxicology, Michigan State University, East Lansing, Michigan 48824, United States.; Department of Environmental Science, Baylor University, Waco, Texas 76798-7266, United States., Khim JS; School of Earth and Environmental Sciences & Research Institute of Oceanography, Seoul National University, Seoul 08826, Republic of Korea.
المصدر:	Environmental science & technology [Environ Sci Technol] 2023 Oct 17; Vol. 57 (41), pp. 15644-15655. Date of Electronic Publication: 2023 Oct 03.
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: American Chemical Society Country of Publication: United States NLM ID: 0213155 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5851 (Electronic) Linking ISSN: 0013936X NLM ISO Abbreviation: Environ Sci Technol Subsets: MEDLINE
أسماء مطبوعة:	Publication: Washington DC : American Chemical Society Original Publication: Easton, Pa. : American Chemical Society, c1967-
مواضيع طبية MeSH:	Liver Extracts/analysis , Fin Whale, Animals ; Receptors, Aryl Hydrocarbon ; Liver ; Republic of Korea
مستخلص:	Major aryl hydrocarbon receptor (AhR) agonists were identified in extracts of blubber, liver, and muscle from six long-beaked common dolphins ( Delphinus capensis ) and one fin whale ( Balaenoptera physalus ) collected from Korean coastal waters using effect-directed analysis. Results of the H4IIE- luc bioassay indicated that the polar fractions of blubber and liver extracts from the fin whale exhibited relatively high AhR-mediated potencies. Based on full-scan screening with high-resolution mass spectrometry, 37 AhR agonist candidates, spanning four use categories: pharmaceuticals, pesticides, cosmetics, and natural products, were selected. Among these, five polar AhR agonists were newly identified through toxicological confirmation. Concentrations of polar AhR agonists in cetaceans were tissue-specific, with extracts of blubber and liver containing greater concentrations than muscle extracts. Polar AhR agonists with great log K OA values (>5) were found to biomagnify in the marine food chain potentially. Polar AhR agonists contributed 8.9% of the observed AhR-mediated potencies in blubber and 49% in liver. Rutaecarpine and alantolactone contributed significantly to the total AhR-mediated potencies of blubber, whereas hydrocortisone was a major AhR contributor in the liver of the fin whale. This study is the first to identify the tissue-specific accumulation of polar AhR agonists in blubber and liver extracts of cetaceans.
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فهرسة مساهمة:	Keywords: H4IIE-luc transactivation bioassay; aryl hydrocarbon receptor-mediated activity; biomagnification; cetaceans; full-scan screening; hierarchical clustering analysis; marine mammals
المشرفين على المادة:	0 (Receptors, Aryl Hydrocarbon) 0 (Liver Extracts)
تواريخ الأحداث:	Date Created: 20231003 Date Completed: 20231023 Latest Revision: 20231023
رمز التحديث:	20231215
مُعرف محوري في PubMed:	PMC10586376
DOI:	10.1021/acs.est.3c04311
PMID:	37787753
قاعدة البيانات:	MEDLINE

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الوصف
تدمد:	1520-5851
DOI:	10.1021/acs.est.3c04311