دورية أكاديمية
أعرض في EDS

Uncovering the complex relationship between balding, testosterone and skin cancers in men.

التفاصيل البيبلوغرافية
العنوان: Uncovering the complex relationship between balding, testosterone and skin cancers in men.
المؤلفون: Ong JS; Population Health Department, QIMR Berghofer Medical Research Institute, Herston, QLD, Australia. JueSheng.Ong@qimrberghofer.edu.au., Seviiri M; Population Health Department, QIMR Berghofer Medical Research Institute, Herston, QLD, Australia.; School of Biomedical Sciences, Faculty of Health, and Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD, Australia., Dusingize JC; Population Health Department, QIMR Berghofer Medical Research Institute, Herston, QLD, Australia., Wu Y; Population Health Department, QIMR Berghofer Medical Research Institute, Herston, QLD, Australia., Han X; Population Health Department, QIMR Berghofer Medical Research Institute, Herston, QLD, Australia.; Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Shi J; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Olsen CM; Population Health Department, QIMR Berghofer Medical Research Institute, Herston, QLD, Australia.; Faculty of Medicine, University of Queensland, Herston, QLD, Australia., Neale RE; Population Health Department, QIMR Berghofer Medical Research Institute, Herston, QLD, Australia., Thompson JF; Melanoma Institute Australia, The University of Sydney, Sydney, NSW, Australia.; Department of Melanoma and Surgical Oncology, Royal Prince Alfred Hospital, Sydney, NSW, Australia., Saw RPM; Melanoma Institute Australia, The University of Sydney, Sydney, NSW, Australia.; Department of Melanoma and Surgical Oncology, Royal Prince Alfred Hospital, Sydney, NSW, Australia., Shannon KF; Melanoma Institute Australia, The University of Sydney, Sydney, NSW, Australia.; Department of Melanoma and Surgical Oncology, Royal Prince Alfred Hospital, Sydney, NSW, Australia., Mann GJ; Melanoma Institute Australia, The University of Sydney, Sydney, NSW, Australia.; Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.; John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia., Martin NG; Department of Mental Health & Neuroscience, QIMR Berghofer Medical Research Institute, Herston, QLD, Australia., Medland SE; Department of Mental Health & Neuroscience, QIMR Berghofer Medical Research Institute, Herston, QLD, Australia., Gordon SD; Department of Mental Health & Neuroscience, QIMR Berghofer Medical Research Institute, Herston, QLD, Australia., Scolyer RA; Melanoma Institute Australia, The University of Sydney, Sydney, NSW, Australia.; Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.; Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital & NSW Health Pathology, Sydney, Australia.; Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia., Long GV; Melanoma Institute Australia, The University of Sydney, Sydney, NSW, Australia.; Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.; Department of Medical Oncology, Royal North Shore Hospital, St Leonards, NSW, Australia., Iles MM; Leeds Institute of Medical Research & Leeds Institute for Data Analytics, University of Leeds, Leeds, UK.; NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, UK., Landi MT; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Whiteman DC; Population Health Department, QIMR Berghofer Medical Research Institute, Herston, QLD, Australia., MacGregor S; Population Health Department, QIMR Berghofer Medical Research Institute, Herston, QLD, Australia., Law MH; Population Health Department, QIMR Berghofer Medical Research Institute, Herston, QLD, Australia. matthew.law@qimrberghofer.edu.au.; School of Biomedical Sciences, Faculty of Health, and Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD, Australia. matthew.law@qimrberghofer.edu.au.
المصدر: Nature communications [Nat Commun] 2023 Oct 03; Vol. 14 (1), pp. 5962. Date of Electronic Publication: 2023 Oct 03.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : Nature Pub. Group
مواضيع طبية MeSH: Skin Neoplasms*/epidemiology , Skin Neoplasms*/genetics , Melanoma*/epidemiology , Melanoma*/genetics, Humans ; Male ; Testosterone ; Ultraviolet Rays/adverse effects ; Alopecia ; Androgens
مستخلص: Male-pattern baldness (MPB) is related to dysregulation of androgens such as testosterone. A previously observed relationship between MPB and skin cancer may be due to greater exposure to ultraviolet radiation or indicate a role for androgenic pathways in the pathogenesis of skin cancers. We dissected this relationship via Mendelian randomization (MR) analyses, using genetic data from recent male-only meta-analyses of cutaneous melanoma (12,232 cases; 20,566 controls) and keratinocyte cancers (KCs) (up to 17,512 cases; >100,000 controls), followed by stratified MR analysis by body-sites. We found strong associations between MPB and the risk of KC, but not with androgens, and multivariable models revealed that this relationship was heavily confounded by MPB single nucleotide polymorphisms involved in pigmentation pathways. Site-stratified MR analyses revealed strong associations between MPB with head and neck squamous cell carcinoma and melanoma, suggesting that sun exposure on the scalp, rather than androgens, is the main driver. Men with less hair covering likely explains, at least in part, the higher incidence of melanoma in men residing in countries with high ambient UV.
(© 2023. Springer Nature Limited.)
References: BMC Cancer. 2021 Apr 16;21(1):420. (PMID: 33863315)
Eur J Epidemiol. 2017 May;32(5):377-389. (PMID: 28527048)
Cell. 2013 Nov 21;155(5):1022-33. (PMID: 24267888)
Nat Genet. 2018 Sep;50(9):1335-1341. (PMID: 30104761)
Mol Cell Endocrinol. 2002 Dec 30;198(1-2):89-95. (PMID: 12573818)
Int J Cancer. 2021 Aug 1;149(3):573-584. (PMID: 33720423)
Melanoma Res. 2002 Dec;12(6):529-38. (PMID: 12459642)
Genet Epidemiol. 2016 May;40(4):304-14. (PMID: 27061298)
J Am Acad Dermatol. 2017 Mar;76(3):494-498.e2. (PMID: 28413056)
Med Sci Monit. 2018 Oct 30;24:7770-7777. (PMID: 30376555)
BMJ. 2018 Jul 12;362:k601. (PMID: 30002074)
Curr Epidemiol Rep. 2019 Jun;6(2):112-118. (PMID: 32855900)
Br J Dermatol. 2015 Mar;172(3):707-15. (PMID: 25333719)
Annu Rev Genomics Hum Genet. 2015;16:327-50. (PMID: 25939054)
Int J Epidemiol. 2017 Dec 1;46(6):1985-1998. (PMID: 29040600)
Elife. 2018 May 30;7:. (PMID: 29846171)
Nat Genet. 2018 Jul;50(7):906-908. (PMID: 29892013)
Nat Commun. 2018 Dec 20;9(1):5407. (PMID: 30573740)
Gigascience. 2015 Feb 25;4:7. (PMID: 25722852)
Int J Epidemiol. 2020 Aug 1;49(4):1236-1245. (PMID: 32068838)
Forensic Sci Int Genet. 2018 Mar;33:38-47. (PMID: 29190509)
Nat Commun. 2020 Feb 21;11(1):1010. (PMID: 32081875)
Nat Med. 2020 Feb;26(2):252-258. (PMID: 32042192)
Hum Mol Genet. 2019 Sep 15;28(18):3148-3160. (PMID: 31174203)
Br J Cancer. 2018 May;118(9):1262-1267. (PMID: 29581483)
Am J Epidemiol. 2015 Feb 15;181(4):251-60. (PMID: 25632051)
J Dtsch Dermatol Ges. 2020 Dec;18(12):1357-1368. (PMID: 33015951)
JAMA Otolaryngol Head Neck Surg. 2019 Nov 01;145(11):1064-1072. (PMID: 31580395)
Nat Commun. 2018 Nov 14;9(1):4774. (PMID: 30429480)
Genet Epidemiol. 2016 Nov;40(7):597-608. (PMID: 27625185)
Br J Dermatol. 2020 Jan;182(1):97-103. (PMID: 31218665)
Int J Cancer. 2016 Dec 15;139(12):2671-2678. (PMID: 27542665)
Int J Epidemiol. 2015 Apr;44(2):512-25. (PMID: 26050253)
Nat Genet. 2018 May;50(5):693-698. (PMID: 29686387)
Int J Epidemiol. 2012 Aug;41(4):929-929i. (PMID: 22933644)
CMAJ. 2021 Oct 4;193(39):E1516-E1524. (PMID: 34607845)
Stat Med. 2021 Nov 10;40(25):5434-5452. (PMID: 34338327)
Int J Epidemiol. 2017 Dec 1;46(6):1734-1739. (PMID: 28398548)
Nucleic Acids Res. 2021 Jan 8;49(D1):D1302-D1310. (PMID: 33196847)
ANZ J Surg. 2021 Dec;91(12):2750-2756. (PMID: 34152687)
Nat Commun. 2017 Mar 08;8:14694. (PMID: 28272467)
Int J Dermatol. 1984 Sep;23(7):444-52. (PMID: 6386712)
Nature. 2018 Oct;562(7726):203-209. (PMID: 30305743)
Genome Biol. 2012 Sep 26;13(9):248. (PMID: 23110848)
Int J Cancer. 2016 Jul 15;139(2):300-9. (PMID: 26941014)
Pigment Cell Melanoma Res. 2013 Jan;26(1):128-35. (PMID: 23095171)
Lancet. 1980 Mar 15;1(8168 Pt 1):562-4. (PMID: 6102285)
PLoS Genet. 2014 Apr 10;10(4):e1004269. (PMID: 24721987)
PLoS Med. 2020 Jul 23;17(7):e1003178. (PMID: 32701947)
Nat Genet. 2020 May;52(5):494-504. (PMID: 32341527)
G Ital Dermatol Venereol. 2014 Feb;149(1):15-24. (PMID: 24566563)
BMJ Open. 2020 May 26;10(5):e032580. (PMID: 32461290)
Arch Pharm Res. 2016 Nov;39(11):1548-1555. (PMID: 27826752)
Biochim Biophys Acta. 2010 Feb;1802(2):292-300. (PMID: 19897031)
PLoS Genet. 2008 May 16;4(5):e1000074. (PMID: 18483556)
Nat Commun. 2017 Nov 17;8(1):1584. (PMID: 29146897)
JAMA Dermatol. 2020 May 1;156(5):553-560. (PMID: 32211827)
معلومات مُعتمدة: United Kingdom DH_ Department of Health
المشرفين على المادة: 3XMK78S47O (Testosterone)
0 (Androgens)
تواريخ الأحداث: Date Created: 20231003 Date Completed: 20231101 Latest Revision: 20231119
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10547720
DOI: 10.1038/s41467-023-41231-8
PMID: 37789011
قاعدة البيانات: MEDLINE
الوصف
تدمد:2041-1723
DOI:10.1038/s41467-023-41231-8