دورية أكاديمية
Safety and immunogenicity of inactivated Rift Valley Fever Smithburn viral vaccine in sheep.
| العنوان: | Safety and immunogenicity of inactivated Rift Valley Fever Smithburn viral vaccine in sheep. |
|---|---|
| المؤلفون: | Matsiela MS; Onderstepoort Biological Products (Pty. Ltd), 100 Old Soutpan Road, Onderstepoort, Pretoria, 0110, South Africa.; Department of Biochemistry, School of Life Sciences, University of KwaZulu-Natal (Pietermaritzburg Campus), Scottsville, 3209, KwaZulu-Natal, South Africa., Naicker L; Onderstepoort Biological Products (Pty. Ltd), 100 Old Soutpan Road, Onderstepoort, Pretoria, 0110, South Africa., Khoza T; Department of Biochemistry, School of Life Sciences, University of KwaZulu-Natal (Pietermaritzburg Campus), Scottsville, 3209, KwaZulu-Natal, South Africa. khozat1@ukzn.ac.za., Mokoena N; Onderstepoort Biological Products (Pty. Ltd), 100 Old Soutpan Road, Onderstepoort, Pretoria, 0110, South Africa. nobalanda@obpvaccines.co.za. |
| المصدر: | Virology journal [Virol J] 2023 Oct 03; Vol. 20 (1), pp. 221. Date of Electronic Publication: 2023 Oct 03. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: BioMed Central Country of Publication: England NLM ID: 101231645 Publication Model: Electronic Cited Medium: Internet ISSN: 1743-422X (Electronic) Linking ISSN: 1743422X NLM ISO Abbreviation: Virol J Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [London] : BioMed Central, 2004- |
| مواضيع طبية MeSH: | Rift Valley Fever*/prevention & control , Rift Valley fever virus* , Sheep Diseases*/prevention & control , Viral Vaccines*, Animals ; Female ; Aluminum Hydroxide ; Antibodies, Neutralizing ; Antibodies, Viral ; Ruminants ; Sheep ; Vaccines, Attenuated ; Vaccines, Inactivated/adverse effects |
| مستخلص: | Background: The live-attenuated Rift Valley Fever Smithburn (SB) vaccine is one of the oldest products widely used in ruminants for control of RVF infections. Vaccinations with RVF Smithburn result in residual pathogenic effect and is limited for use in non-pregnant animals. Commercially available RVFV inactivated vaccines are considered safer options to control the disease. These products are prepared from virulent RVFV isolates and present occupational safety concerns. This research study evaluates the ability of an inactivated SB vaccine strain to elicit neutralising antibody response in sheep. Methods: The RVF Smithburn vaccine was inactivated with binary ethylenimine at 37 °C. Inactivated RVFV cultures were adjuvanted with Montande™ Gel-01 and aluminium hydroxide (Al (OH) Results: Inactivated RVFV vaccine formulations were safe with all animals showing no clinical signs of RVFV infection and temperature reactions following prime-boost injections. The aluminium hydroxide formulated vaccine induced an immune response as early as 14 days post primary vaccination with neutralising antibody titre of 1:20 and a peak antibody titre of 1:83 was reached on day 56. A similar trend was observed in the animal group vaccinated with the commercial inactivated RVF vaccine obtaining the highest antibody titre of 1:128 on day 56. The neutralizing antibody levels remained within a threshold for the duration of the study. Merino sheep vaccinated with Montanide™ Gel-01-Smithburn were characterised with overall lower immune response when compared to aluminium hydroxide vaccine emulsions. Conclusions: These finding suggests that the inactivated RVF Smithburn vaccine strain adjuvanted with aluminium-hydroxide can be used an alternative to the products prepared from virulent RVFV isolates for protection of ruminants against the disease. The vaccine can further be evaluated for safety in pregnant ewes. (© 2023. BioMed Central Ltd., part of Springer Nature.) |
| References: | J Virol Methods. 1991 Aug;33(3):367-74. (PMID: 1723736) EFSA J. 2020 Mar 06;18(3):e06041. (PMID: 33020705) Expert Rev Vaccines. 2017 Jun;16(6):601-611. (PMID: 28425834) J Immunol. 2011 Jan 15;186(2):1022-31. (PMID: 21169548) Emerg Infect Dis. 2011 Dec;17(12):2270-6. (PMID: 22172568) Vaccines (Basel). 2017 Sep 19;5(3):. (PMID: 28925970) J Immunol. 2008 Sep 15;181(6):4168-76. (PMID: 18768874) Nat Biotechnol. 2010 Jun;28(6):573-9. (PMID: 20531338) BMJ Glob Health. 2020 Aug;5(8):. (PMID: 32816810) PLoS Negl Trop Dis. 2018 May 9;12(5):e0006474. (PMID: 29742102) Arch Virol. 1975;47(1):47-56. (PMID: 167679) PLoS Negl Trop Dis. 2020 Jan 21;14(1):e0007898. (PMID: 31961862) J Immunol. 2004 May 1;172(9):5598-605. (PMID: 15100303) J Immunol Res. 2016;2016:7346294. (PMID: 27689098) Vet Microbiol. 2007 Mar 31;121(1-2):29-38. (PMID: 17187944) J S Afr Vet Assoc. 1977 Mar;48(1):45-8. (PMID: 874947) Curr Opin Virol. 2018 Apr;29:8-15. (PMID: 29514112) Trop Med Infect Dis. 2020 Jun 02;5(2):. (PMID: 32498264) J Med Virol. 2006 Jun;78(6):787-91. (PMID: 16628582) Vaccine X. 2022 Aug 18;12:100209. (PMID: 36051749) Br J Exp Pathol. 1949 Feb;30(1):1-16. (PMID: 18128091) Bacteriophage. 2011 Mar;1(2):86-93. (PMID: 22334864) Med Microbiol Immunol. 2016 Oct;205(5):409-24. (PMID: 27193020) Acta Trop. 2022 Aug;232:106498. (PMID: 35513072) Onderstepoort J Vet Res. 2014 May 27;81(1):. (PMID: 25686466) Vaccine. 1991 Jan;9(1):35-41. (PMID: 2008798) J Am Vet Med Assoc. 2009 Apr 1;234(7):883-93. (PMID: 19335238) Access Microbiol. 2020 Dec 17;3(3):000191. (PMID: 34151150) Curr Mol Med. 2005 Dec;5(8):827-34. (PMID: 16375716) Zentralbl Veterinarmed B. 1971 Feb 1;18(1):61-71. (PMID: 4996842) Front Vet Sci. 2020 May 19;7:256. (PMID: 32509806) Vaccine X. 2020 Jul 29;6:100070. (PMID: 32793877) Vaccine X. 2020 Apr 09;5:100060. (PMID: 32337506) Vet Res. 2010 Nov-Dec;41(6):61. (PMID: 21188836) |
| فهرسة مساهمة: | Keywords: Aluminium hydroxide adjuvant; Montanide™ Gel-01 adjuvant; Rift valley fever virus; Smithburn vaccine; Virus inactivation |
| المشرفين على المادة: | 5QB0T2IUN0 (Aluminum Hydroxide) 0 (Antibodies, Neutralizing) 0 (Antibodies, Viral) 0 (Vaccines, Attenuated) 0 (Vaccines, Inactivated) 0 (Viral Vaccines) |
| تواريخ الأحداث: | Date Created: 20231003 Date Completed: 20231102 Latest Revision: 20231121 |
| رمز التحديث: | 20231121 |
| مُعرف محوري في PubMed: | PMC10548704 |
| DOI: | 10.1186/s12985-023-02180-2 |
| PMID: | 37789354 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1743-422X |
|---|---|
| DOI: | 10.1186/s12985-023-02180-2 |