دورية أكاديمية
أعرض في EDS

The association between history of retained placenta and success rate of misoprostol treatment for early pregnancy failure.

التفاصيل البيبلوغرافية
العنوان: The association between history of retained placenta and success rate of misoprostol treatment for early pregnancy failure.
المؤلفون: Cohen A; Department of Obstetrics and Gynecology, Hadassah Medical Organization, Faculty of Medicine, Hebrew University of Jerusalem, Ein Kerem, Jerusalem, P.O.B. 12000, 91120, Israel. adielic@gmail.com., Gutman-Ido E; Department of Obstetrics and Gynecology, Hadassah Medical Organization, Faculty of Medicine, Hebrew University of Jerusalem, Ein Kerem, Jerusalem, P.O.B. 12000, 91120, Israel., Karavani G; Department of Obstetrics and Gynecology, Hadassah Medical Organization, Faculty of Medicine, Hebrew University of Jerusalem, Ein Kerem, Jerusalem, P.O.B. 12000, 91120, Israel., Albeck A; Department of Internal Medicine, Hadassah Medical Organization, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel., Rosenbloom JI; Department of Obstetrics and Gynecology, Hadassah Medical Organization, Faculty of Medicine, Hebrew University of Jerusalem, Ein Kerem, Jerusalem, P.O.B. 12000, 91120, Israel., Shushan A; Department of Obstetrics and Gynecology, Hadassah Medical Organization, Faculty of Medicine, Hebrew University of Jerusalem, Ein Kerem, Jerusalem, P.O.B. 12000, 91120, Israel., Chill HH; Division of Urogynecology, University of Chicago Pritzker School of Medicine, NorthShore University HealthSystem, Skokie, IL, USA.
المصدر: BMC women's health [BMC Womens Health] 2023 Oct 04; Vol. 23 (1), pp. 523. Date of Electronic Publication: 2023 Oct 04.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101088690 Publication Model: Electronic Cited Medium: Internet ISSN: 1472-6874 (Electronic) Linking ISSN: 14726874 NLM ISO Abbreviation: BMC Womens Health Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : BioMed Central, 2001-
مواضيع طبية MeSH: Misoprostol*/therapeutic use , Abortifacient Agents, Nonsteroidal*/therapeutic use , Placenta, Retained*/drug therapy , Placenta, Retained*/chemically induced , Abortion, Spontaneous*/chemically induced, Pregnancy ; Humans ; Female ; Retrospective Studies ; Treatment Outcome ; Pregnancy Trimester, First
مستخلص: Background: To date, the association between retained placenta and treatment success rate of misoprostol for early pregnancy failure has yet to be evaluated. The aim of this study was to evaluate this association and further investigated the connection between medical, clinical and sonographic parameters and treatment success.
Methods: We conducted a retrospective cohort study of women with early pregnancy failure treated with misoprostol from 2006 to 2021. The success rate of misoprostol treatment was compared between patients with history of retained placenta including women who underwent manual lysis of the placenta following delivery or patients who were found to have retained products of conception during their post-partum period (study group) and patients without such history (controls). Demographic, clinical, and sonographic characteristics as well as treatment outcomes were compared between the groups.
Results: A total of 271 women were included in the study (34 women in the study group compared to 237 women in the control group). Two-hundred and thirty-three women (86.0%) presented with missed abortion, and 38 (14.0%) with blighted ovum. Success rates of misoprostol treatment were 61.8% and 78.5% for the study and control groups, respectively (p = 0.032). Univariate analysis performed comparing successful vs. failed misoprostol treatment showed advanced age, gravidity, parity and gestational sac size (mm) on TVUS were associated with higher misoprostol treatment failure rate. Following a multivariate logistic regression model these variables did not reach statistical significance.
Conclusion: Women who have an event of retained placenta following childbirth appear to have decreased success rate of treatment with misoprostol for early pregnancy failure. Larger studies are needed to confirm this finding.
(© 2023. BioMed Central Ltd., part of Springer Nature.)
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فهرسة مساهمة: Keywords: Blighted ovum; Early pregnancy failure; First trimester miscarriage; Missed abortion; Retained placenta, retained products of conception
المشرفين على المادة: 0E43V0BB57 (Misoprostol)
0 (Abortifacient Agents, Nonsteroidal)
تواريخ الأحداث: Date Created: 20231004 Date Completed: 20231006 Latest Revision: 20231123
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10552386
DOI: 10.1186/s12905-023-02666-9
PMID: 37794425
قاعدة البيانات: MEDLINE
الوصف
تدمد:1472-6874
DOI:10.1186/s12905-023-02666-9