دورية أكاديمية
أعرض في EDS

An early-life microbiota metabolite protects against obesity by regulating intestinal lipid metabolism.

التفاصيل البيبلوغرافية
العنوان: An early-life microbiota metabolite protects against obesity by regulating intestinal lipid metabolism.
المؤلفون: Shelton CD; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Sing E; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Mo J; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Shealy NG; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Yoo W; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang 37673, Republic of Korea., Thomas J; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Fitz GN; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA., Castro PR; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Laboratory of Immunoinflammation, Department of Genetics, Evolution, Microbiology, and Immunology, Institute of Biology, University of Campinas, Campinas, São Paulo 12083-862, Brazil., Hickman TT; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA., Torres TP; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Foegeding NJ; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Zieba JK; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Calcutt MW; Mass Spectrometry Research Center and Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA., Codreanu SG; Center for Innovative Technology and Department of Chemistry, Vanderbilt University, Nashville, TN 37232, USA., Sherrod SD; Center for Innovative Technology and Department of Chemistry, Vanderbilt University, Nashville, TN 37232, USA., McLean JA; Center for Innovative Technology and Department of Chemistry, Vanderbilt University, Nashville, TN 37232, USA., Peck SH; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA; Department of Biomedical Engineering, Vanderbilt University School of Engineering, Nashville, TN 37232, USA; Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN, USA; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Yang F; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Markham NO; Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN, USA; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN, USA; Vanderbilt Institute of Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Liu M; Department of Pathology and Molecular Medicine, Metabolic Diseases Institute, University of Cincinnati College of Medicine, Cincinnati, OH 45237, USA., Byndloss MX; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Vanderbilt Institute of Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Vanderbilt Digestive Disease Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Vanderbilt Microbiome Innovation Center, Vanderbilt University, Nashville, TN 37235, USA; Howard Hughes Medical Institute, Vanderbilt University Medical Center, Nashville, TN 37232, USA. Electronic address: mariana.x.byndloss@vumc.org.
المصدر: Cell host & microbe [Cell Host Microbe] 2023 Oct 11; Vol. 31 (10), pp. 1604-1619.e10. Date of Electronic Publication: 2023 Oct 03.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101302316 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1934-6069 (Electronic) Linking ISSN: 19313128 NLM ISO Abbreviation: Cell Host Microbe Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Cambridge, Mass. : Cell Press
مواضيع طبية MeSH: Pediatric Obesity* , Microbiota*, Humans ; Child ; Animals ; Mice ; Lipid Metabolism ; Diet, High-Fat/adverse effects ; Anti-Bacterial Agents ; Polyesters ; Mice, Inbred C57BL
مستخلص: The mechanisms by which the early-life microbiota protects against environmental factors that promote childhood obesity remain largely unknown. Using a mouse model in which young mice are simultaneously exposed to antibiotics and a high-fat (HF) diet, we show that Lactobacillus species, predominant members of the small intestine (SI) microbiota, regulate intestinal epithelial cells (IECs) to limit diet-induced obesity during early life. A Lactobacillus-derived metabolite, phenyllactic acid (PLA), protects against metabolic dysfunction caused by early-life exposure to antibiotics and a HF diet by increasing the abundance of peroxisome proliferator-activated receptor γ (PPAR-γ) in SI IECs. Therefore, PLA is a microbiota-derived metabolite that activates protective pathways in the small intestinal epithelium to regulate intestinal lipid metabolism and prevent antibiotic-associated obesity during early life.
Competing Interests: Declaration of interests The authors declare no competing interests.
(Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.)
التعليقات: Comment in: Cell Metab. 2023 Dec 5;35(12):2099-2100. (PMID: 38056427)
References: Nat Commun. 2021 Feb 10;12(1):903. (PMID: 33568676)
Nat Microbiol. 2021 Nov;6(11):1367-1382. (PMID: 34675385)
JAMA Netw Open. 2020 Jan 3;3(1):e1919681. (PMID: 31968118)
Cell Host Microbe. 2008 Apr 17;3(4):213-23. (PMID: 18407065)
Nature. 2012 Aug 30;488(7413):621-6. (PMID: 22914093)
Nat Rev Microbiol. 2014 Jul;12(7):465-78. (PMID: 24861036)
Science. 2021 Aug 13;373(6556):813-818. (PMID: 34385401)
J Cell Physiol. 2017 Jan;232(1):167-75. (PMID: 27061934)
Infect Immun. 2008 Mar;76(3):907-15. (PMID: 18160481)
Int J Obes (Lond). 2014 Aug;38(8):1115-9. (PMID: 24257411)
J Biol Chem. 2021 Jan-Jun;296:100052. (PMID: 33168624)
Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4333-7. (PMID: 9539737)
Diabetol Metab Syndr. 2014 Jun 02;6:70. (PMID: 25028601)
Cell Host Microbe. 2018 Apr 11;23(4):458-469.e5. (PMID: 29649441)
Am J Physiol Gastrointest Liver Physiol. 2011 May;300(5):G803-14. (PMID: 21350192)
Bioinformatics. 2014 Apr 1;30(7):923-30. (PMID: 24227677)
Sci Rep. 2017 Mar 07;7:43199. (PMID: 28266623)
Nat Rev Gastroenterol Hepatol. 2020 Mar;17(3):169-183. (PMID: 32015520)
Proc Natl Acad Sci U S A. 2002 Aug 20;99(17):11482-6. (PMID: 12177411)
Proc Natl Acad Sci U S A. 1993 Jan 15;90(2):587-91. (PMID: 7678459)
J Dairy Sci. 2015 Feb;98(2):813-7. (PMID: 25434344)
PLoS One. 2015 May 06;10(5):e0125371. (PMID: 25946041)
mBio. 2018 Sep 4;9(5):. (PMID: 30181250)
J Exp Biol. 2021 Feb 25;224(Pt 4):. (PMID: 33431595)
Ther Drug Monit. 2005 Dec;27(6):747-51. (PMID: 16404815)
Science. 2017 Sep 1;357(6354):912-916. (PMID: 28860383)
Biochem J. 2006 Apr 15;395(2):393-403. (PMID: 16393142)
Genome Biol. 2014;15(12):550. (PMID: 25516281)
Gastroenterology. 2004 Jul;127(1):139-44. (PMID: 15236180)
Nat Commun. 2016 Jan 26;7:10410. (PMID: 26811868)
Environ Microbiol Rep. 2016 Jun;8(3):399-406. (PMID: 27043715)
BMC Med. 2019 Nov 25;17(1):212. (PMID: 31760948)
Cell Host Microbe. 2012 Sep 13;12(3):277-88. (PMID: 22980325)
Cell Death Dis. 2019 Jan 15;10(2):39. (PMID: 30674874)
Proc Natl Acad Sci U S A. 2010 Jun 29;107(26):11971-5. (PMID: 20566857)
Gut. 2013 Sep;62(9):1306-14. (PMID: 22722618)
PLoS One. 2010 Sep 30;5(9):. (PMID: 20927337)
Nat Commun. 2015 Jun 30;6:7486. (PMID: 26123276)
Arterioscler Thromb Vasc Biol. 2014 Mar;34(3):644-53. (PMID: 24407032)
PLoS One. 2012;7(10):e46837. (PMID: 23056479)
ISME J. 2012 Jul;6(7):1415-26. (PMID: 22258098)
Nature. 2012 May 09;486(7402):222-7. (PMID: 22699611)
FEMS Microbiol Lett. 2004 Apr 15;233(2):289-95. (PMID: 15063498)
Nat Commun. 2014 Dec 05;5:5648. (PMID: 25476696)
Cell Host Microbe. 2016 Oct 12;20(4):515-526. (PMID: 27693307)
Sci Transl Med. 2016 Jun 15;8(343):343ra82. (PMID: 27306664)
Science. 2016 Apr 29;352(6285):539-44. (PMID: 27126036)
Nature. 2012 Sep 13;489(7415):231-41. (PMID: 22972296)
Am J Physiol Endocrinol Metab. 2006 Nov;291(5):E1092-9. (PMID: 16822957)
Int J Obes (Lond). 2018 Jun;42(5):1088-1091. (PMID: 29463918)
Mol Cell Biol. 2013 Apr;33(7):1303-16. (PMID: 23339868)
Cell Host Microbe. 2020 Mar 11;27(3):358-375.e7. (PMID: 32101704)
J Agric Food Chem. 2019 Jul 10;67(27):7569-7586. (PMID: 31198037)
Int J Obes (Lond). 2010 Oct;34(10):1531-7. (PMID: 20231842)
Curr Protoc Microbiol. 2008 May;Chapter 13:Unit 13C.1. (PMID: 18770533)
Bioinformatics. 2013 Jan 1;29(1):15-21. (PMID: 23104886)
Int J Mol Sci. 2017 Nov 28;18(12):. (PMID: 29182565)
JAMA Netw Open. 2020 Jan 3;3(1):e1917577. (PMID: 31968112)
Trends Microbiol. 2019 Dec;27(12):997-1010. (PMID: 31474424)
J Food Sci. 2016 Jan;81(1):H216-22. (PMID: 26595891)
Front Microbiol. 2020 Jan 10;10:2999. (PMID: 31998276)
Biochim Biophys Acta. 1996 May 20;1300(3):151-70. (PMID: 8679680)
Cell. 2014 Aug 14;158(4):705-721. (PMID: 25126780)
Nat Metab. 2022 Dec;4(12):1713-1731. (PMID: 36456724)
Methods Mol Biol. 2013;952:117-35. (PMID: 23100228)
J Am Soc Mass Spectrom. 2016 Dec;27(12):1897-1905. (PMID: 27624161)
Nucleic Acids Res. 2013 Jan;41(Database issue):D801-7. (PMID: 23161693)
Elife. 2020 Dec 08;9:. (PMID: 33287959)
Eur J Nutr. 2015 Apr;54(3):355-63. (PMID: 24830782)
Endocrinology. 2005 Jan;146(1):247-55. (PMID: 15486228)
Mol Metab. 2013 Nov 20;3(2):135-44. (PMID: 24634819)
Elife. 2021 Jan 08;10:. (PMID: 33416496)
Am J Clin Nutr. 2018 Oct 1;108(4):868-877. (PMID: 30247504)
Cell Host Microbe. 2021 May 12;29(5):765-776.e3. (PMID: 33794185)
Pediatrics. 2018 Jun;141(6):. (PMID: 29793986)
Mayo Clin Proc. 2017 Feb;92(2):251-265. (PMID: 28065514)
Proc Natl Acad Sci U S A. 2011 Mar 15;108 Suppl 1:4592-8. (PMID: 20937873)
Front Physiol. 2020 Jul 07;11:797. (PMID: 32733284)
Am J Physiol Regul Integr Comp Physiol. 2011 Dec;301(6):R1738-47. (PMID: 21900644)
Science. 2017 Aug 11;357(6351):570-575. (PMID: 28798125)
Am J Physiol Gastrointest Liver Physiol. 2021 Jul 1;321(1):G75-G86. (PMID: 34009042)
Molecules. 2015 Aug 24;20(8):15359-73. (PMID: 26305241)
معلومات مُعتمدة: IK2 BX005699 United States BX BLRD VA; T32 DK007673 United States DK NIDDK NIH HHS; S10 OD023475 United States OD NIH HHS; R01 DK131104 United States DK NIDDK NIH HHS; P30 DK058404 United States DK NIDDK NIH HHS; S10 OD021630 United States OD NIH HHS; T32 AI112541 United States AI NIAID NIH HHS; S10 OD026929 United States OD NIH HHS; P30 EY008126 United States EY NEI NIH HHS; T32 ES007028 United States ES NIEHS NIH HHS; R01 AI168302 United States AI NIAID NIH HHS; U24 DK059637 United States DK NIDDK NIH HHS; IK2 BX005401 United States BX BLRD VA; P30 DK020593 United States DK NIDDK NIH HHS; P30 CA068485 United States CA NCI NIH HHS; F31 AI161882 United States AI NIAID NIH HHS
فهرسة مساهمة: Keywords: Lactobacillus; antibiotics; arachnoid barrier; brain fibroblasts; early-life; intestinal epithelium; leptomeninges; metabolism; microbiota; obesity; single-cell RNA sequencing; tricellular junction
المشرفين على المادة: 0 (Anti-Bacterial Agents)
0 (Polyesters)
تواريخ الأحداث: Date Created: 20231005 Date Completed: 20231026 Latest Revision: 20240320
رمز التحديث: 20240321
مُعرف محوري في PubMed: PMC10593428
DOI: 10.1016/j.chom.2023.09.002
PMID: 37794592
قاعدة البيانات: MEDLINE
الوصف
تدمد:1934-6069
DOI:10.1016/j.chom.2023.09.002