دورية أكاديمية

Impact of baseline and interim quantitative PET parameters on outcomes of classical Hodgkin Lymphoma.

التفاصيل البيبلوغرافية
العنوان: Impact of baseline and interim quantitative PET parameters on outcomes of classical Hodgkin Lymphoma.
المؤلفون: Santos FM; Instituto Do Cancer Do Estado de Sao Paulo (ICESP), Faculdade de Medicina, Universidade de Sao Paulo (FMUSP), Sao Paulo-SP, Brazil. fernanda.maria@hc.fm.usp.br., Marin JFG; Nuclear Medicine Medical Investigation Laboratory LIM43, Hospital das Clinicas, FMUSP (HCFMUSP), Sao Paulo-SP, Brazil., Lima MS; Instituto Do Cancer Do Estado de Sao Paulo (ICESP), Faculdade de Medicina, Universidade de Sao Paulo (FMUSP), Sao Paulo-SP, Brazil.; Nuclear Medicine Medical Investigation Laboratory LIM43, Hospital das Clinicas, FMUSP (HCFMUSP), Sao Paulo-SP, Brazil., Silva-Junior WF; Instituto Do Cancer Do Estado de Sao Paulo (ICESP), Faculdade de Medicina, Universidade de Sao Paulo (FMUSP), Sao Paulo-SP, Brazil.; Division of Hematology and Cell Therapy, HCFMUSP, Sao Paulo-SP, Brazil., Alves LBO; Division of Hematology and Cell Therapy, HCFMUSP, Sao Paulo-SP, Brazil., Moreira FR; Division of Hematology and Cell Therapy, HCFMUSP, Sao Paulo-SP, Brazil., Velasques RD; Instituto Do Cancer Do Estado de Sao Paulo (ICESP), Faculdade de Medicina, Universidade de Sao Paulo (FMUSP), Sao Paulo-SP, Brazil.; Division of Hematology and Cell Therapy, HCFMUSP, Sao Paulo-SP, Brazil., Atanazio MJ; Instituto Do Cancer Do Estado de Sao Paulo (ICESP), Faculdade de Medicina, Universidade de Sao Paulo (FMUSP), Sao Paulo-SP, Brazil.; Division of Hematology and Cell Therapy, HCFMUSP, Sao Paulo-SP, Brazil., Maia ACA; Instituto Do Cancer Do Estado de Sao Paulo (ICESP), Faculdade de Medicina, Universidade de Sao Paulo (FMUSP), Sao Paulo-SP, Brazil.; Division of Hematology and Cell Therapy, HCFMUSP, Sao Paulo-SP, Brazil., Buchpiguel CA; Nuclear Medicine Medical Investigation Laboratory LIM43, Hospital das Clinicas, FMUSP (HCFMUSP), Sao Paulo-SP, Brazil., Buccheri V; Instituto Do Cancer Do Estado de Sao Paulo (ICESP), Faculdade de Medicina, Universidade de Sao Paulo (FMUSP), Sao Paulo-SP, Brazil.; Division of Hematology and Cell Therapy, HCFMUSP, Sao Paulo-SP, Brazil.; Laboratory of Medical Investigation in Pathogenesis and Targeted Therapy in Onco-Immuno-Hematology (LIM-31), Department of Internal Medicine, Division of Hematology, HCFMUSP, Sao Paulo-SP, Brazil., Rocha V; Instituto Do Cancer Do Estado de Sao Paulo (ICESP), Faculdade de Medicina, Universidade de Sao Paulo (FMUSP), Sao Paulo-SP, Brazil.; Division of Hematology and Cell Therapy, HCFMUSP, Sao Paulo-SP, Brazil.; Laboratory of Medical Investigation in Pathogenesis and Targeted Therapy in Onco-Immuno-Hematology (LIM-31), Department of Internal Medicine, Division of Hematology, HCFMUSP, Sao Paulo-SP, Brazil.; Department of Hematology, Churchill Hospital, NHS BT, Oxford University, Oxford, UK.
المصدر: Annals of hematology [Ann Hematol] 2024 Jan; Vol. 103 (1), pp. 175-183. Date of Electronic Publication: 2023 Oct 05.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 9107334 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0584 (Electronic) Linking ISSN: 09395555 NLM ISO Abbreviation: Ann Hematol Subsets: MEDLINE
أسماء مطبوعة: Publication: Berlin : Springer Verlag
Original Publication: Berlin ; New York : Springer International, c1991-
مواضيع طبية MeSH: Hodgkin Disease*/diagnostic imaging , Hodgkin Disease*/drug therapy, Humans ; Adult ; Retrospective Studies ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Fluorodeoxyglucose F18 ; Bleomycin ; Dacarbazine ; Doxorubicin ; Vinblastine ; Prognosis ; Positron Emission Tomography Computed Tomography ; Positron-Emission Tomography
مستخلص: Currently, analysis of interim PET (iPET) according to the Deauville score (DS) is the most important predictive factor in Hodgkin lymphoma (HL); however, there is room for improvement in its prognostic power. This study aimed to evaluate the prognostic value of quantitative PET analysis (maximum standard uptake value [SUV max ], total metabolic tumor volume [TMTV] and total lesion glicolysis [TLG]) at baseline (PET0) and iPET in a retrospective cohort of newly diagnosed classical HL. For positive iPET (+ iPET), the reduction of quantitative parameters in relation to PET0 (ΔSUV max , ΔTMTV and ΔTLG) was calculated. Between 2011 and 2017, 234 patients treated with ABVD were analyzed. Median age was 30 years-old, 59% had advanced stage disease, 57% a bulky mass and 25% a + iPET (DS 4-5). At baseline, high TLG was associated with an increased cumulative incidence of failure (CIF) (p = 0.032) while neither SUV max , TMTV or TLG were associated with overall survival (OS) or progression-free survival (PFS). In multivariate analysis, only iPET was associated with CIF (p < 0.001). Among ΔSUV max , ΔTMTV and ΔTLG, only a ΔSUV max  ≥ 68.8 was significant for PFS (HR: 0.31, CI95%: 0.11-0.86, p = 0.024). A subset of patients with improved PFS amongst + iPET was identified by the quantitative (ΔSUV max  ≥ 68.8%) analysis. In this real-world Brazilian cohort, with prevalent high-risk patients, quantitative analysis of PET0 did not demonstrate to be prognostic, while a dynamic approach incorporating the ΔSUV max to + iPET succeeded in refining a subset with better prognosis. These findings warrant validation in larger series and indicate that not all patients with + iPET might need treatment intensification.
(© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
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فهرسة مساهمة: Keywords: Hodgkin lymphoma; Metabolic tumor volume; Positron emission tomography; Total lesion glycolysis
المشرفين على المادة: 0Z5B2CJX4D (Fluorodeoxyglucose F18)
11056-06-7 (Bleomycin)
7GR28W0FJI (Dacarbazine)
80168379AG (Doxorubicin)
5V9KLZ54CY (Vinblastine)
تواريخ الأحداث: Date Created: 20231005 Date Completed: 20240103 Latest Revision: 20240103
رمز التحديث: 20240103
DOI: 10.1007/s00277-023-05461-6
PMID: 37796339
قاعدة البيانات: MEDLINE
الوصف
تدمد:1432-0584
DOI:10.1007/s00277-023-05461-6