دورية أكاديمية
Airway surveillance and lung viral control by memory T cells induced by COVID-19 mRNA vaccine.
العنوان: | Airway surveillance and lung viral control by memory T cells induced by COVID-19 mRNA vaccine. |
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المؤلفون: | Kingstad-Bakke B; Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA., Cleven T; Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA., Bussan H; Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA., Yount BL Jr; Department of Microbiology and Immunology, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina, USA., Uraki R; Division of Virology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.; The Research Center for Global Viral Diseases, National Center for Global Health and Medicine Research Institute, Tokyo, Japan., Iwatsuki-Horimoto K; Division of Virology, Institute of Medical Science, University of Tokyo, Tokyo, Japan., Koga M; Department of Infectious Diseases and Applied Immunology, IMSUT Hospital of The Institute of Medical Science, and.; Division of Infectious Diseases, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan., Yamamoto S; Division of Virology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.; Division of Infectious Diseases, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan., Yotsuyanagi H; Department of Infectious Diseases and Applied Immunology, IMSUT Hospital of The Institute of Medical Science, and.; Division of Infectious Diseases, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan., Park H; Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA., Mishra JS; Department of Comparative Biosciences, University of Wisconsin-Madison, Madison, Wisconsin, USA., Kumar S; Department of Comparative Biosciences, University of Wisconsin-Madison, Madison, Wisconsin, USA., Baric RS; Department of Microbiology and Immunology, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina, USA., Halfmann PJ; Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA., Kawaoka Y; Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Division of Virology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.; The Research Center for Global Viral Diseases, National Center for Global Health and Medicine Research Institute, Tokyo, Japan.; The University of Tokyo, Pandemic Preparedness, Infection and Advanced Research Center (UTOPIA), Tokyo, Japan., Suresh M; Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA. |
المصدر: | JCI insight [JCI Insight] 2023 Nov 22; Vol. 8 (22). Date of Electronic Publication: 2023 Nov 22. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model: Electronic Cited Medium: Internet ISSN: 2379-3708 (Electronic) Linking ISSN: 23793708 NLM ISO Abbreviation: JCI Insight Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Ann Arbor, Michigan : American Society for Clinical Investigation, [2016]- |
مواضيع طبية MeSH: | COVID-19 Vaccines* , COVID-19*/prevention & control, Humans ; Animals ; Mice ; Memory T Cells ; SARS-CoV-2 ; Lung |
مستخلص: | Although SARS-CoV-2 evolution seeds a continuous stream of antibody-evasive viral variants, COVID-19 mRNA vaccines provide robust protection against severe disease and hospitalization. Here, we asked whether mRNA vaccine-induced memory T cells limit lung SARS-CoV-2 replication and severe disease. We show that mice and humans receiving booster BioNTech mRNA vaccine developed potent CD8 T cell responses and showed similar kinetics of expansion and contraction of granzyme B/perforin-expressing effector CD8 T cells. Both monovalent and bivalent mRNA vaccines elicited strong expansion of a heterogeneous pool of terminal effectors and memory precursor effector CD8 T cells in spleen, inguinal and mediastinal lymph nodes, pulmonary vasculature, and most surprisingly in the airways, suggestive of systemic and regional surveillance. Furthermore, we document that: (a) CD8 T cell memory persists in multiple tissues for > 200 days; (b) following challenge with pathogenic SARS-CoV-2, circulating memory CD8 T cells rapidly extravasate to the lungs and promote expeditious viral clearance, by mechanisms that require CD4 T cell help; and (c) adoptively transferred splenic memory CD8 T cells traffic to the airways and promote lung SARS-CoV-2 clearance. These findings provide insights into the critical role of memory T cells in preventing severe lung disease following breakthrough infections with antibody-evasive SARS-CoV-2 variants. |
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معلومات مُعتمدة: | R21 AI149793 United States AI NIAID NIH HHS; R21 AI173757 United States AI NIAID NIH HHS; U01 AI124299 United States AI NIAID NIH HHS |
فهرسة مساهمة: | Keywords: COVID-19; Cellular immune response; Immunology; Memory; T cells |
المشرفين على المادة: | 0 (COVID-19 Vaccines) |
SCR Organism: | SARS-CoV-2 variants |
تواريخ الأحداث: | Date Created: 20231005 Date Completed: 20231127 Latest Revision: 20231216 |
رمز التحديث: | 20231216 |
مُعرف محوري في PubMed: | PMC10721330 |
DOI: | 10.1172/jci.insight.172510 |
PMID: | 37796612 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2379-3708 |
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DOI: | 10.1172/jci.insight.172510 |