دورية أكاديمية
أعرض في EDS

Airway surveillance and lung viral control by memory T cells induced by COVID-19 mRNA vaccine.

التفاصيل البيبلوغرافية
العنوان: Airway surveillance and lung viral control by memory T cells induced by COVID-19 mRNA vaccine.
المؤلفون: Kingstad-Bakke B; Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA., Cleven T; Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA., Bussan H; Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA., Yount BL Jr; Department of Microbiology and Immunology, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina, USA., Uraki R; Division of Virology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.; The Research Center for Global Viral Diseases, National Center for Global Health and Medicine Research Institute, Tokyo, Japan., Iwatsuki-Horimoto K; Division of Virology, Institute of Medical Science, University of Tokyo, Tokyo, Japan., Koga M; Department of Infectious Diseases and Applied Immunology, IMSUT Hospital of The Institute of Medical Science, and.; Division of Infectious Diseases, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan., Yamamoto S; Division of Virology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.; Division of Infectious Diseases, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan., Yotsuyanagi H; Department of Infectious Diseases and Applied Immunology, IMSUT Hospital of The Institute of Medical Science, and.; Division of Infectious Diseases, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan., Park H; Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA., Mishra JS; Department of Comparative Biosciences, University of Wisconsin-Madison, Madison, Wisconsin, USA., Kumar S; Department of Comparative Biosciences, University of Wisconsin-Madison, Madison, Wisconsin, USA., Baric RS; Department of Microbiology and Immunology, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina, USA., Halfmann PJ; Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA., Kawaoka Y; Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Division of Virology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.; The Research Center for Global Viral Diseases, National Center for Global Health and Medicine Research Institute, Tokyo, Japan.; The University of Tokyo, Pandemic Preparedness, Infection and Advanced Research Center (UTOPIA), Tokyo, Japan., Suresh M; Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA.
المصدر: JCI insight [JCI Insight] 2023 Nov 22; Vol. 8 (22). Date of Electronic Publication: 2023 Nov 22.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model: Electronic Cited Medium: Internet ISSN: 2379-3708 (Electronic) Linking ISSN: 23793708 NLM ISO Abbreviation: JCI Insight Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Ann Arbor, Michigan : American Society for Clinical Investigation, [2016]-
مواضيع طبية MeSH: COVID-19 Vaccines* , COVID-19*/prevention & control, Humans ; Animals ; Mice ; Memory T Cells ; SARS-CoV-2 ; Lung
مستخلص: Although SARS-CoV-2 evolution seeds a continuous stream of antibody-evasive viral variants, COVID-19 mRNA vaccines provide robust protection against severe disease and hospitalization. Here, we asked whether mRNA vaccine-induced memory T cells limit lung SARS-CoV-2 replication and severe disease. We show that mice and humans receiving booster BioNTech mRNA vaccine developed potent CD8 T cell responses and showed similar kinetics of expansion and contraction of granzyme B/perforin-expressing effector CD8 T cells. Both monovalent and bivalent mRNA vaccines elicited strong expansion of a heterogeneous pool of terminal effectors and memory precursor effector CD8 T cells in spleen, inguinal and mediastinal lymph nodes, pulmonary vasculature, and most surprisingly in the airways, suggestive of systemic and regional surveillance. Furthermore, we document that: (a) CD8 T cell memory persists in multiple tissues for > 200 days; (b) following challenge with pathogenic SARS-CoV-2, circulating memory CD8 T cells rapidly extravasate to the lungs and promote expeditious viral clearance, by mechanisms that require CD4 T cell help; and (c) adoptively transferred splenic memory CD8 T cells traffic to the airways and promote lung SARS-CoV-2 clearance. These findings provide insights into the critical role of memory T cells in preventing severe lung disease following breakthrough infections with antibody-evasive SARS-CoV-2 variants.
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معلومات مُعتمدة: R21 AI149793 United States AI NIAID NIH HHS; R21 AI173757 United States AI NIAID NIH HHS; U01 AI124299 United States AI NIAID NIH HHS
فهرسة مساهمة: Keywords: COVID-19; Cellular immune response; Immunology; Memory; T cells
المشرفين على المادة: 0 (COVID-19 Vaccines)
SCR Organism: SARS-CoV-2 variants
تواريخ الأحداث: Date Created: 20231005 Date Completed: 20231127 Latest Revision: 20231216
رمز التحديث: 20231216
مُعرف محوري في PubMed: PMC10721330
DOI: 10.1172/jci.insight.172510
PMID: 37796612
قاعدة البيانات: MEDLINE
الوصف
تدمد:2379-3708
DOI:10.1172/jci.insight.172510