دورية أكاديمية
Microrheology and structural quantification of hypercoagulable clots.
العنوان: | Microrheology and structural quantification of hypercoagulable clots. |
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المؤلفون: | Wolff-Trombini L; Université de Bordeaux, UMR1034, Inserm, Biology of Cardiovascular Diseases, Pessac, France., Ceripa A; LMS, CNRS, Ecole Polytechnique, Institut Polytechnique de Paris, Palaiseau, France.; Inria, Palaiseau, France., Moreau J; Université Paris-Saclay, Institut d'Optique Graduate School, CNRS, Laboratoire Charles Fabry, Palaiseau, France., Galinat H; CHU de Brest, Service d'Hématologie Biologique, Brest, France., James C; Université de Bordeaux, UMR1034, Inserm, Biology of Cardiovascular Diseases, Pessac, France.; CHU de Bordeaux, Laboratoire d'Hématologie, Pessac, France., Westbrook N; Université Paris-Saclay, Institut d'Optique Graduate School, CNRS, Laboratoire Charles Fabry, Palaiseau, France., Allain JM; LMS, CNRS, Ecole Polytechnique, Institut Polytechnique de Paris, Palaiseau, France.; Inria, Palaiseau, France. |
المصدر: | Biomedical optics express [Biomed Opt Express] 2023 Jul 19; Vol. 14 (8), pp. 4179-4189. Date of Electronic Publication: 2023 Jul 19 (Print Publication: 2023). |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Optica Publishing Group Country of Publication: United States NLM ID: 101540630 Publication Model: eCollection Cited Medium: Print ISSN: 2156-7085 (Print) Linking ISSN: 21567085 NLM ISO Abbreviation: Biomed Opt Express Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Publication: Washington, DC : Optica Publishing Group Original Publication: Washington, DC : Optical Society of America |
مستخلص: | Hypercoagulability is a pathology that remains difficult to explain today in most cases. It is likely due to a modification of the conditions of polymerization of the fibrin, the main clot component. Using passive microrheology, we measured the mechanical properties of clots and correlated them under the same conditions with structural information obtained with confocal microscopy. We tested our approach with known alterations: an excess of fibrinogen and of coagulation Factor VIII. We observed simultaneously a rigidification and densification of the fibrin network, showing the potential of microrheology for hypercoagulability diagnosis. Competing Interests: The authors declare no competing interests. (© 2023 Optica Publishing Group under the terms of the Optica Open Access Publishing Agreement.) |
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تواريخ الأحداث: | Date Created: 20231006 Latest Revision: 20231026 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC10549726 |
DOI: | 10.1364/BOE.492669 |
PMID: | 37799698 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2156-7085 |
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DOI: | 10.1364/BOE.492669 |