دورية أكاديمية
Ant Venom-Based Ceramide Therapy Is Effective Against Atopic Dermatitis In Vivo.
| العنوان: | Ant Venom-Based Ceramide Therapy Is Effective Against Atopic Dermatitis In Vivo. |
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| المؤلفون: | Leyva-Castillo JM, Huang C, Baker P, Bacsa J, Geha RS, Arbiser JL |
| المصدر: | Journal of drugs in dermatology : JDD [J Drugs Dermatol] 2023 Oct 01; Vol. 22 (10), pp. 1001-1006. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Physicians Continuing Education Corporation Country of Publication: United States NLM ID: 101160020 Publication Model: Print Cited Medium: Internet ISSN: 1545-9616 (Print) Linking ISSN: 15459616 NLM ISO Abbreviation: J Drugs Dermatol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2007- > : New York, NY : Physicians Continuing Education Corporation Original Publication: New York, NY : Strategic Communication in Dermatology |
| مواضيع طبية MeSH: | Dermatitis, Atopic*/drug therapy , Ant Venoms*/therapeutic use , Psoriasis*/drug therapy, Humans ; Mice ; Animals ; Ceramides/therapeutic use ; Anti-Inflammatory Agents/therapeutic use |
| مستخلص: | Background: Atopic dermatitis (AD) is a common skin condition with relatively few therapeutic alternatives. These include corticosteroids, which address inflammation but not superinfection, and Januse kinase (JAK) inhibitors, which have a US Food and Drug Administration (FDA) black box for potential carcinogenicity. Methods: We demonstrate that S14, a synthetic derivative of ant venom-derived solenopsin, has potent anti inflammatory effects on the OVA murine model of atopic dermatitis. S14 has demonstrated prior activity in murine psoriasis and has the benefit of ceramide anti-inflammatory effects without being able to be metabolized into proinflammatory sphingosine-1 phosphate. Results: The efficacy of S14 accompanied by the induction of IL-12 suggests a commonality in inflammatory skin disorders, and our results suggest that pharmacological ceramide restoration will be broadly effective for inflammatory skin disease. Conclusions: Solenopsin derivative S14 has anti-inflammatory effects in murine models of AD and psoriasis. This makes S14 a strong candidate for human use, and pre-IND studies are warranted.J Drugs Dermatol. 2023;22(10):1001-1006 doi:10.36849/JDD.7308. |
| المشرفين على المادة: | 0 (Ant Venoms) 0 (Ceramides) 0 (Anti-Inflammatory Agents) |
| تواريخ الأحداث: | Date Created: 20231006 Date Completed: 20231102 Latest Revision: 20231102 |
| رمز التحديث: | 20231102 |
| DOI: | 10.36849/JDD.7308 |
| PMID: | 37801525 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1545-9616 |
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| DOI: | 10.36849/JDD.7308 |