دورية أكاديمية
Evaluation of seasonal influences on adrenocorticotropic hormone response to the thyrotropin-releasing hormone stimulation test and its accuracy for diagnosis of pituitary pars intermedia dysfunction.
| العنوان: | Evaluation of seasonal influences on adrenocorticotropic hormone response to the thyrotropin-releasing hormone stimulation test and its accuracy for diagnosis of pituitary pars intermedia dysfunction. |
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| المؤلفون: | Adams AA; Gluck Equine Research Center, Department of Veterinary Science, University of Kentucky, Lexington, KY 40546, USA., Siard-Altman MH; Equine Studies, Department of Science & Health, Asbury University, One Macklem Drive, Wilmore, KY 40390, USA., Reedy SE; Gluck Equine Research Center, Department of Veterinary Science, University of Kentucky, Lexington, KY 40546, USA., Barker D; Gluck Equine Research Center, Department of Veterinary Science, University of Kentucky, Lexington, KY 40546, USA., Elzinga S; Neurology Department, Michigan Medicine, University of Michigan, Ann Arbor, MI 48103, USA., Sanz MG; Washington Animal Disease Diagnostic Laboratory, Washington State University,1940 SE Olympia Ave, Pullman, WA 99164-7034, USA., Urschel K; Department of Animal and Food Sciences, University of Kentucky, Lexington, KY 40546-0215, USA., Ireland JL; Institute of Infection, Veterinary and Ecological Sciences, Faculty of Health and Life Sciences, The University of Liverpool, Leahurst Campus, Neston, Cheshire CH64 7TE, UK. Electronic address: Joanne.Ireland@liverpool.ac.uk. |
| المصدر: | Veterinary journal (London, England : 1997) [Vet J] 2023 Oct-Dec; Vol. 300-302, pp. 106035. Date of Electronic Publication: 2023 Oct 05. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Balliere Tindall Country of Publication: England NLM ID: 9706281 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2971 (Electronic) Linking ISSN: 10900233 NLM ISO Abbreviation: Vet J Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Balliere Tindall Original Publication: London : Ballière Tindall, c1997- |
| مواضيع طبية MeSH: | Pituitary Diseases*/diagnosis , Pituitary Diseases*/veterinary , Pituitary Gland, Intermediate*/metabolism , Horse Diseases*/diagnosis, Horses ; Animals ; Adrenocorticotropic Hormone/pharmacology ; Thyrotropin-Releasing Hormone/pharmacology ; Seasons ; Cohort Studies |
| مستخلص: | Pituitary pars intermedia dysfunction (PPID) is an age-related neurodegenerative disorder, affecting >20 % of older horses. There is a need for improved endocrine tests for early disease detection, and the thyrotropin-releasing hormone (TRH) stimulation test has been recommended for diagnosis of early or mild cases. However, it is currently not recommended for year-round use due to marked seasonal variability. The aims of this cohort study were to evaluate effects of month and season on adrenocorticotropic hormone (ACTH) responses to TRH stimulation and to derive monthly cut-offs for PPID diagnosis. Sixty-three horses were assigned to control (n = 17), subclinical PPID (n = 21) and clinical PPID (n = 25) groups, based on a composite reference standard that combined clinical history and examination findings with endocrine test results. TRH stimulation tests were performed monthly for a 12-month period. Circannual changes were evaluated with one- and two-way repeated-measures analysis of variance and receiver operating characteristic curve analysis was used to derive cut-off values for basal and TRH-stimulated ACTH. TRH-stimulated ACTH concentrations were lowest in February-May and highest in August-October. Specificity of both basal and 30 min post-TRH ACTH was generally higher than sensitivity, and TRH stimulation had improved diagnostic accuracy compared to basal ACTH, although its sensitivity was not significantly greater year-round. TRH stimulation tests yielded considerably more positive results than basal ACTH in the subclinical group, but few additional positive results in clinical PPID cases. There were large differences between cut-offs that maximised sensitivity or specificity for TRH-stimulated ACTH, highlighting the importance of considering clinical presentation alongside test results in diagnostic decision-making. Competing Interests: Conflict of interest None of the authors has any financial or personal relationships that could inappropriately influence or bias the content of the paper. (Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.) |
| فهرسة مساهمة: | Keywords: ACTH; Circannual; Diagnostic cut-off value; Equine Cushing's; PPID |
| المشرفين على المادة: | 9002-60-2 (Adrenocorticotropic Hormone) 5Y5F15120W (Thyrotropin-Releasing Hormone) |
| تواريخ الأحداث: | Date Created: 20231006 Date Completed: 20231201 Latest Revision: 20240501 |
| رمز التحديث: | 20240501 |
| DOI: | 10.1016/j.tvjl.2023.106035 |
| PMID: | 37802466 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1532-2971 |
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| DOI: | 10.1016/j.tvjl.2023.106035 |