دورية أكاديمية
Long-range air dispersion of Candida auris in a cardiothoracic unit outbreak in Hong Kong.
| العنوان: | Long-range air dispersion of Candida auris in a cardiothoracic unit outbreak in Hong Kong. |
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| المؤلفون: | Didik T; Department of Pathology, Queen Elizabeth Hospital, Hong Kong Special Administrative Region, China; Department of Pathology, Hong Kong Children's Hospital, Hong Kong Special Administrative Region, China., Yau AP; Department of Respiratory Medicine, Kowloon Hospital, Hong Kong Special Administrative Region, China., Cheung HL; Department of Cardiothoracic Surgery, Queen Elizabeth Hospital, Hong Kong Special Administrative Region, China., Lee SY; Infection Control Team, Queen Elizabeth Hospital, Hong Kong Special Administrative Region, China., Chan NH; Infection Control Team, Queen Elizabeth Hospital, Hong Kong Special Administrative Region, China., Wah YT; Infection Control Team, Kowloon Hospital, Hong Kong Special Administrative Region, China., Luk HK; Department of Pathology, Queen Elizabeth Hospital, Hong Kong Special Administrative Region, China., Choi GK; Department of Pathology, Hong Kong Children's Hospital, Hong Kong Special Administrative Region, China., Cheng NH; Department of Pathology, Queen Elizabeth Hospital, Hong Kong Special Administrative Region, China., Tse H; Department of Laboratory Medicine, Khoo Teck Puat Hospital, Singapore., Li Y; Department of Mechanical Engineering, Faculty of Engineering, The University of Hong Kong, Hong Kong Special Administrative Region, China., Wong SCY; Department of Pathology, Queen Elizabeth Hospital, Hong Kong Special Administrative Region, China; Department of Pathology, Hong Kong Children's Hospital, Hong Kong Special Administrative Region, China., Lung DC; Department of Pathology, Queen Elizabeth Hospital, Hong Kong Special Administrative Region, China; Department of Pathology, Hong Kong Children's Hospital, Hong Kong Special Administrative Region, China. Electronic address: lungdc@ha.org.hk. |
| المصدر: | The Journal of hospital infection [J Hosp Infect] 2023 Dec; Vol. 142, pp. 105-114. Date of Electronic Publication: 2023 Oct 06. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: W.B. Saunders For The Hospital Infection Society Country of Publication: England NLM ID: 8007166 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2939 (Electronic) Linking ISSN: 01956701 NLM ISO Abbreviation: J Hosp Infect Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : W.B. Saunders For The Hospital Infection Society Original Publication: New York, Academic Press. |
| مواضيع طبية MeSH: | Candidiasis*/epidemiology , Cross Infection*/epidemiology, Humans ; Candida ; Candida auris ; Phylogeny ; Hong Kong/epidemiology ; Disease Outbreaks ; Microbial Sensitivity Tests ; Antifungal Agents |
| مستخلص: | Background: Nosocomial outbreaks of Candida auris, a multidrug-resistant fungus, are increasingly reported worldwide; the mode of transmission has usually been reported to be via direct contact. Some studies previously suggested potential short-distance air dispersal during high-turbulence activities, but evidence on long-range air dispersal remains scarce. Aim: To describe a C. auris nosocomial outbreak involving two wards (H7, 5E) in two local hospitals. Methods: Samples were taken from patients, ward surfaces (frequently touched items and non-reachable surfaces) while settle plates were used for passive air sampling to investigate possible contributions by direct contact and air dispersal. Epidemiological and phylogenetic analyses were also performed on the C. auris isolates from this outbreak. Findings: Eighteen patients were confirmed to have asymptomatic C. auris skin colonization. C. auris was expectedly identified in samplings from frequently touched ward items but was also isolated in two samples from ceiling supply air grilles which were 2.4 m high and inaccessible by patients. Moreover, one sample from a corridor return air grille as far as 9.8 m away from the C. auris cohort area was also positive. Two passive air samplings were positive, including one from a cubicle with no confirmed cases for four days, suggesting possible air dispersal of C. auris. Whole-genome sequencing confirmed clonality of air, environment, and patients' isolates. Conclusion: This is the first study to demonstrate potential long-range air dispersal of C. auris in an open-cubicle ward setting. Ventilation precautions and decontamination of out-of-reach high-level surfaces should be considered in C. auris outbreak management. (Copyright © 2023 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Air; Candida auris; Fungal outbreaks; Multidrug-resistant candida; Nosocomial outbreaks; Ventilation |
| المشرفين على المادة: | 0 (Antifungal Agents) |
| تواريخ الأحداث: | Date Created: 20231008 Date Completed: 20231127 Latest Revision: 20231127 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.jhin.2023.09.019 |
| PMID: | 37806452 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1532-2939 |
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| DOI: | 10.1016/j.jhin.2023.09.019 |