دورية أكاديمية
أعرض في EDS

Generating Retinas through Guided Pluripotent Stem Cell Differentiation and Direct Somatic Cell Reprogramming.

التفاصيل البيبلوغرافية
العنوان: Generating Retinas through Guided Pluripotent Stem Cell Differentiation and Direct Somatic Cell Reprogramming.
المؤلفون: Zhang K; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, 510623, China., Cai W; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, 510623, China., Hu L; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, 510623, China., Chen S; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, 510623, China.
المصدر: Current stem cell research & therapy [Curr Stem Cell Res Ther] 2024; Vol. 19 (9), pp. 1251-1262.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Bentham Science Publishers Country of Publication: United Arab Emirates NLM ID: 101272517 Publication Model: Print Cited Medium: Internet ISSN: 2212-3946 (Electronic) Linking ISSN: 1574888X NLM ISO Abbreviation: Curr Stem Cell Res Ther Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Saif Zone, Sharjah, U.A.E. ; San Francisco, CA : Bentham Science Publishers, c2006-
مواضيع طبية MeSH: Cell Differentiation* , Cellular Reprogramming*/genetics , Retina*/cytology , Pluripotent Stem Cells*/cytology , Pluripotent Stem Cells*/physiology, Humans ; Animals ; Retinal Degeneration/therapy ; Retinal Degeneration/pathology ; Induced Pluripotent Stem Cells/cytology
مستخلص: Retinal degeneration diseases affect millions of people worldwide but are among the most difficult eye diseases to cure. Studying the mechanisms and developing new therapies for these blinding diseases requires researchers to have access to many retinal cells. In recent years there has been substantial advances in the field of biotechnology in generating retinal cells and even tissues in vitro , either through programmed sequential stem cell differentiation or direct somatic cell lineage reprogramming. The resemblance of these in vitro -generated retinal cells to native cells has been increasingly utilized by researchers. With the help of these in vitro retinal models, we now have a better understanding of human retinas and retinal diseases. Furthermore, these in vitro -generated retinal cells can be used as donor cells which solves a major hurdle in the development of cell replacement therapy for retinal degeneration diseases, while providing a promising option for patients suffering from these diseases. In this review, we summarize the development of pluripotent stem cell-to-retinal cell differentiation methods, the recent advances in generating retinal cells through direct somatic cell reprogramming, and the translational applications of retinal cells generated in vitro . Finally, we discuss the limitations of the current protocols and possible future directions for improvement.
(Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
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فهرسة مساهمة: Keywords: RPE.; Retina; photoreceptor; pluripotent stem cell; reprogramming; retinal ganglion cell; retinal organoid
تواريخ الأحداث: Date Created: 20231009 Date Completed: 20240903 Latest Revision: 20240903
رمز التحديث: 20240903
DOI: 10.2174/011574888X255496230923164547
PMID: 37807418
قاعدة البيانات: MEDLINE
الوصف
تدمد:2212-3946
DOI:10.2174/011574888X255496230923164547