دورية أكاديمية
[Diurnal differences in acute gout attacks: A clinical study of male gout patients].
| العنوان: | [Diurnal differences in acute gout attacks: A clinical study of male gout patients]. |
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| المؤلفون: | Dong H; Department of Rheumatology and Immunology, PLA Joint Logistic Support Force No.980 Hospital, Shijiazhuang 050082, China.; The Graduate School, Hebei Medical University, Shijiazhuang 050011, China., Wang LM; Department of Rheumatology and Immunology, PLA Joint Logistic Support Force No.980 Hospital, Shijiazhuang 050082, China., Wang ZQ; Department of Rheumatology and Immunology, PLA Joint Logistic Support Force No.980 Hospital, Shijiazhuang 050082, China., Liu YQ; Department of Rheumatology and Immunology, PLA Joint Logistic Support Force No.980 Hospital, Shijiazhuang 050082, China., Zhang XG; Department of Rheumatology and Immunology, PLA Joint Logistic Support Force No.980 Hospital, Shijiazhuang 050082, China., Zhang MM; Department of Rheumatology and Immunology, PLA Joint Logistic Support Force No.980 Hospital, Shijiazhuang 050082, China., Liu J; Department of Rheumatology and Immunology, PLA Joint Logistic Support Force No.980 Hospital, Shijiazhuang 050082, China., Li ZB; Department of Rheumatology and Immunology, PLA Joint Logistic Support Force No.980 Hospital, Shijiazhuang 050082, China. |
| المصدر: | Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences [Beijing Da Xue Xue Bao Yi Xue Ban] 2023 Oct 18; Vol. 55 (5), pp. 915-922. |
| نوع المنشور: | English Abstract; Journal Article |
| اللغة: | Chinese |
| بيانات الدورية: | Publisher: Beijing da xue Country of Publication: China NLM ID: 101125284 Publication Model: Print Cited Medium: Print ISSN: 1671-167X (Print) Linking ISSN: 1671167X NLM ISO Abbreviation: Beijing Da Xue Xue Bao Yi Xue Ban Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Beijing : Beijing da xue, 2001- |
| مواضيع طبية MeSH: | Gout*/drug therapy , Arthritis, Gouty*, Humans ; Male ; Cross-Sectional Studies ; Gout Suppressants/therapeutic use ; Comorbidity |
| مستخلص: | Objective: To observe the diurnal difference of acute gout attacks in men, and provide reference for accurate clinical prevention and treatment. Methods: Using a single-center, cross-sectional study design, the patients diagnosed with gout in the outpatient department of Rheumatology and Immuno-logy of PLA Joint Logistic Support Force No.980 Hospital from October 2021 to April 2022 were selected. The information about the patient's current/last acute gout attacks (less than 2 weeks from visit), date and time of attacks, joint symptoms and signs, medication use, and relevant biochemical tests on the day of visit was recorded. The diurnal time difference of acute gout attacks in male patients was analyzed, and univariate comparison and multivariate Logistic regression analyses were conducted to compare the diurnal difference of acute gout attacks with clinical characteristics and biochemical indicators. Results: A total of 100 male gout patients were included, and 100 acute attacks were recorded. Diurnal distribution of acute gout attacks: morning (6:00~11:59, 18, 18%), afternoon (12:00~17:59, 11, 11%), the first half of the night (18:00~23:59, 22, 22%), the second half of the night (0:00~05:59, 49, 49%); During the day (included morning and afternoon, 29, 29%) and at night (included the first half of the night and the second half of the night, 71, 71%). The rate of acute gout attack was significantly higher at night than in the day (about 2.5 ∶1). No matter the first or recurrent gout, no matter the duration of the disease, the number of acute gout attacks had the difference of less in the day and more in the night. Serum urate (SU) level was higher in the patients with nocturnal attack than in those with daytime attack ( P =0.044). Comorbidities were significantly different in the day-night ratio of the number of acute gout attack ( P =0.028). Multiple Logistic regression analysis showed that SU level ( OR =1.005, 95% CI : 1.001-1.009) and comorbidities ( OR =3.812, 95% CI : 1.443-10.144) were the correlative factors of nocturnal acute gout attacks. Conclusion: No matter the first or recurrent gout, no matter the duration of the disease, it has a diurnal variation characterized by multiple attacks at night, increased SU level and comorbidities are correlative factors for nocturnal acute attack of gout. |
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| فهرسة مساهمة: | Keywords: Acute attack; Diurnal difference; Gout |
| المشرفين على المادة: | 0 (Gout Suppressants) |
| تواريخ الأحداث: | Date Created: 20231009 Date Completed: 20231101 Latest Revision: 20231101 |
| رمز التحديث: | 20231101 |
| مُعرف محوري في PubMed: | PMC10560896 |
| PMID: | 37807748 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1671-167X |
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