دورية أكاديمية
أعرض في EDS

Identification and characterization of murine glycoprotein 2-expressing intestinal dendritic cells.

التفاصيل البيبلوغرافية
العنوان: Identification and characterization of murine glycoprotein 2-expressing intestinal dendritic cells.
المؤلفون: Luda KM; Immunology Section, Department of Experimental Medical Science, Lund University, Lund, Sweden., Da Silva C; Immunology Section, Department of Experimental Medical Science, Lund University, Lund, Sweden., Ahmadi F; Immunology Section, Department of Experimental Medical Science, Lund University, Lund, Sweden., Mowat AM; Centre for Immunobiology, Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary Medicine and Life Sciences, University of Glasgow, Glasgow, UK., Ohno H; RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Kotarsky K; Immunology Section, Department of Experimental Medical Science, Lund University, Lund, Sweden., Agace WW; Immunology Section, Department of Experimental Medical Science, Lund University, Lund, Sweden.; Mucosal Immunology Laboratory, Department of Health Technology, Technical University of Denmark, Lyngby, Denmark.
المصدر: Scandinavian journal of immunology [Scand J Immunol] 2022 Nov; Vol. 96 (5), pp. e13219. Date of Electronic Publication: 2022 Oct 17.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 0323767 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-3083 (Electronic) Linking ISSN: 03009475 NLM ISO Abbreviation: Scand J Immunol Subsets: MEDLINE
أسماء مطبوعة: Publication: Oxford : Blackwell Scientific Publications
Original Publication: Oslo, Universitetsforlaget.
مواضيع طبية MeSH: Intestines* , Integrin alpha Chains*, Mice ; Animals ; Intestinal Mucosa ; Intestine, Small ; Signal Transduction ; Dendritic Cells ; Mice, Inbred C57BL
مستخلص: The intestinal lamina propria (LP) contains distinct subsets of classical dendritic cells (cDC), each playing key non-redundant roles in intestinal immune homeostasis. Here, we show that glycoprotein 2 (GP2), a GPI-anchored protein and receptor for bacterial type-I fimbriae, is selectively expressed by CD103 + CD11b + cDC in the murine small intestine (SI). GP2 expression was induced on CD103 + CD11b + cDC within the SI-LP and was regulated by IRF4, TGFβR1- and retinoic acid signalling. Mice selectively lacking Gp2 on CD103 + CD11b + cDC (huLang-Cre.gp2 fl/fl mice) had normal numbers and proportions of innate and adaptive immune cells in the SI-LP suggesting that GP2 expression by CD103 + CD11b + cDC is not required for intestinal immune homoeostasis.
(© 2022 The Authors. Scandinavian Journal of Immunology published by John Wiley & Sons Ltd on behalf of The Scandinavian Foundation for Immunology.)
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معلومات مُعتمدة: 18 0598 Cancerfonden; 211661 Pj Cancerfonden; Greta och Johan Kocks stiftelser; Richard and Ruth Juhlin stiftelse; Stiftelsen Professor Nanna Svartz Fond; Swedish National Health Service; The Royal Physiographic Society; 2017-02072 Vetenskapsrådet
فهرسة مساهمة: Keywords: IRF4; TGFβR1; cDC2; dendritic cell; homeostasis; intestine; retinoic acid
المشرفين على المادة: 0 (Integrin alpha Chains)
تواريخ الأحداث: Date Created: 20231009 Date Completed: 20231102 Latest Revision: 20231102
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC9786990
DOI: 10.1111/sji.13219
PMID: 37807915
قاعدة البيانات: MEDLINE
الوصف
تدمد:1365-3083
DOI:10.1111/sji.13219