دورية أكاديمية
أعرض في EDS

Impact of ACE2 gene variations on COVID-19 pathogenicity in Pakistani patients.

التفاصيل البيبلوغرافية
العنوان: Impact of ACE2 gene variations on COVID-19 pathogenicity in Pakistani patients.
المؤلفون: Waryah YM; Scientific Ophthalmic and Research Laboratory, Sindh Institute of Ophthalmology and Visual Sciences, Hyderabad 71500, Pakistan.; Department of Pathology, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan., Khidri FF; Department of Biochemistry, Bilawal Medical College, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan.; Department of Molecular Biology and Genetics, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan., Nigar R; Department of Gynecology, Bilawal Medical College, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan., Devrajani T; Department of Medicine, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan., Rajput AR; Department of Pathology, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan.; Department of Molecular Biology and Genetics, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan., Waryah AM; Department of Pathology, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan.; Department of Molecular Biology and Genetics, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan., Ujjan ID; Department of Pathology, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan.
المصدر: Saudi journal of biological sciences [Saudi J Biol Sci] 2023 Oct; Vol. 30 (10), pp. 103813. Date of Electronic Publication: 2023 Sep 20.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Saudi Biological Society Country of Publication: Saudi Arabia NLM ID: 101543796 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1319-562X (Print) Linking ISSN: 22137106 NLM ISO Abbreviation: Saudi J Biol Sci Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Riyadh : Saudi Biological Society : King Saud University, [2009]-
مستخلص: Background: COVID-19, caused by the SARS-CoV-2 virus, swiftly disseminated and was declared a pandemic. Variations in the ACE2 gene can impact the virus's ability to bind to ACE2 receptor, potentially influencing an individual's susceptibility and its association with COVID-19 severity across various populations.
Methods: In total, 200 individuals were sequenced for the ACE2 gene and potential impact of the found variants on the ACE2 protein was assessed using in-silico tools.
Results: Eight variations in the ACE2 gene were identified in 27 COVID-19 patients, of which four were missense and four were intronic variants. Three variants had a MAF of < 0.01 (c.251C > T, p.Pro86Leu; 15C > G, p.S5S; and c. 91 A > G, p.Lys31Glu). A missense variant, p.Pro86Leu, C > T, TT genotype, was found in 9 out of 200 individuals with an allele frequency of 0.045 and showed a significant association with COVID-19 (P = 0.003). The heterozygous allele of 15C > G, p.S5S, was found with a frequency of 0.02 (8/400) in eight patients, and its CG genotype showed a significant association with COVID-19 (P = 0.0068). The remaining identified variants were not associated with COVID-19 susceptibility.
Conclusion: The ACE2 gene sequence in Pakistani individuals exhibited a low frequency of identified variants in COVID-19 patients. Overall, only two variants were associated with susceptibility to the disease, possibly contributing to Pakistan's lower COVID-19 mortality and infection rates. However, individuals carrying the mutant variant experienced more severe symptoms.
Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(© 2023 The Author(s).)
References: Bioinformatics. 2018 Jun 1;34(11):1937-1938. (PMID: 29360956)
Int J Microbiol. 2023 Jan 4;2023:4540287. (PMID: 36644496)
PLoS One. 2021 May 27;16(5):e0251754. (PMID: 34043674)
Scand J Work Environ Health. 2020 May 1;46(3):229-230. (PMID: 32356896)
PLoS One. 2022 Mar 2;17(3):e0264547. (PMID: 35235580)
Diabetes Metab Syndr. 2020 Sep - Oct;14(5):1037-1041. (PMID: 32640415)
Curr Drug Targets. 2021;22(3):254-281. (PMID: 33081670)
Mol Vis. 2014 Jul 07;20:991-1001. (PMID: 25018621)
Psychol Res Behav Manag. 2022 May 25;15:1311-1323. (PMID: 35642191)
J Med Virol. 2020 Sep;92(9):1580-1586. (PMID: 32249956)
Nature. 2020 Mar;579(7798):270-273. (PMID: 32015507)
J Med Virol. 2023 Jan;95(1):e28128. (PMID: 36068170)
Infez Med. 2020 Mar 1;28(1):3-5. (PMID: 32009128)
J Mol Med (Berl). 2020 Nov;98(11):1505-1509. (PMID: 32935155)
Aging (Albany NY). 2020 May 29;12(10):9959-9981. (PMID: 32470948)
J Pers Med. 2021 Oct 27;11(11):. (PMID: 34834450)
Front Public Health. 2020 Jul 28;8:418. (PMID: 32850607)
Lancet. 2020 Feb 29;395(10225):689-697. (PMID: 32014114)
Science. 2020 Sep 25;369(6511):1586-1592. (PMID: 32694201)
Clin Microbiol Rev. 2020 Jun 24;33(4):. (PMID: 32580969)
PLoS One. 2020 Dec 28;15(12):e0243887. (PMID: 33370311)
Science. 2020 Mar 27;367(6485):1444-1448. (PMID: 32132184)
J Genet. 2021;100:. (PMID: 33707363)
Gene. 2013 Oct 10;528(2):356-9. (PMID: 23886590)
J Biol Chem. 2000 Oct 27;275(43):33238-43. (PMID: 10924499)
Crit Care. 2020 Jul 13;24(1):422. (PMID: 32660650)
Cell. 2020 Apr 16;181(2):271-280.e8. (PMID: 32142651)
Mol Biol Rep. 2023 May;50(5):4309-4316. (PMID: 36920597)
J Glob Health. 2020 Dec;10(2):020348. (PMID: 33110546)
فهرسة مساهمة: Keywords: ACE2; COVID-19; Gene; Pakistan; Variants
تواريخ الأحداث: Date Created: 20231009 Latest Revision: 20231031
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC10550763
DOI: 10.1016/j.sjbs.2023.103813
PMID: 37811480
قاعدة البيانات: MEDLINE
الوصف
تدمد:1319-562X
DOI:10.1016/j.sjbs.2023.103813